Description overdue on 08/21/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Mikardis, instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Micardis One tablet contains 40 or 80 mg telmisartan   (active substance).

Excipients: sodium hydroxide, polyvidone, meglumine, sorbitol, magnesium stearate.

Product form

The medicine is white pills, oblong, engraved with "51H" at one end and the company's logo - on the other edge.

7 such Tablets 40 mg dose in a blister, 2 or 4 of the blister pack in a cardboard. Either 7 such Tablets 80 mg dose in a blister, 2, 4 or 8 of the blister pack in a cardboard

Pharmacological action

Suppression Angiotensin II   and as a result, vasodilatation. The drug lowers blood pressure, contents aldosterone   in blood.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Telmisartan   - Selective receptor blocker Angiotensin II . It has a high tropism for AT1   subtype receptors Angiotensin II . It competes with Angiotensin II   in specific receptors, not having the same effect. The binding is long-term in nature.

It has no affinity for other receptor subtypes. Reduces aldosterone   blood does not inhibit renin in plasma and ion channels in cells.

Start the hypotensive effect of   observed during the first three hours after administration telmisartan . The action persists for a day or more. The pronounced effect develops a month after continuous use.

In individuals with hypertension telmisartan   reduces systolic and diastolic blood pressure, but does not change the number of heartbeats.

There is no withdrawal.

Pharmacokinetics

When taken orally is rapidly absorbed from the intestine. Bioavailability is close to 50%. After three hours, plasma concentration becomes maximum. 99, 5% of the active substance is bound to blood proteins. It is metabolized by reacting with glucuronic acid . Metabolites of the drug inactive. The half-life is more than 20 hours. Displayed through the digestive tract, urinary excretion - less than 2%.

Indications

• Hypertension.
• Reduction of cardiac morbidity and mortality in persons older than 55 years are at risk.

Contraindications

Micardis Tablets are contraindicated for people with Allergies   the drug components, heavy Diseases liver   or   kidney .   fructose intolerance . Pregnancy   and Lactation Children under 18 years.

Side effects

• On the part of the central nervous system: depression , Dizziness, headache , Fatigue, anxiety, insomnia . convulsions .
• From the respiratory system: upper respiratory tract infection ( sinusitis . pharyngitis . bronchitis ), Cough.
• From the circulatory system: pronounced reduction in pressure . tachycardia . bradycardia Pain in the chest.
• From the digestive system: nausea, diarrhea . dyspepsia Increasing the concentration of hepatic enzymes.
• From the musculoskeletal system: myalgia , Back pain, arthralgia .
• With the genitourinary system: swelling, infections of the genitourinary system, hypercreatininemia .
• Hypersensitivity reactions: skin rash, angioedema . hives .
• Laboratory findings: anemia . hyperkalemia .
• Other: erythema , Itching, dyspnea .

Mikardis, instructions for use

According to the instructions for use of the drug is taken orally Mikardisa. Adults are recommended dose of 40 mg   once a day. In some patients the therapeutic effect has been observed in the use of dose   20 mg   per day. If the pressure is reduced to the desired level is observed, the dose can be increased to 80 mg per day.

The maximum effect of the drug is achieved within five weeks after initiation of therapy.

In patients with severe hypertension   you can use 160 mg drug per day.

Overdose

Symptoms: excessive lowering of blood pressure.

Treatment: symptomatic.

Cooperation

Telmisartan   activates hypotensive effect   other means of pressure reduction.

In a joint application telmisartan   and Digoxin   the need for periodic determination of the concentration Digoxin   in the blood, as it may rise.

In a joint reception drugs lithium   and   ACE inhibitors   It may be a temporary increase in lithium blood, shown toxic effects.

Treatment NSAIDs   with Mikardisom in dehydrated patients may lead to acute renal failure.

Terms of sale

It sold strictly on prescription.

Storage conditions

Store in a closed container at a temperature of 30 ° C, in a dry place. Keep away from children.

Shelf life

Four years.

Cautions

To dehydrated patients   (restriction of salt intake, treatment diuretics . diarrhea , Vomiting) to reduce the dose Mikardisa.

Be wary appoint persons with stenosis of both renal arteries . Mitral valve stenosis or aorta, hypertrophic cardiomyopathy   obstructive nature, severe renal, hepatic or cardiac insufficiency, diseases of the digestive tract.

Prohibited use in primary aldosteronism and fructose intolerance .

When planned pregnancy is necessary to find a replacement in advance Mikardisu others antihypertensive drug .

Used with caution when driving.

When concomitantly with drugs lithium   shows monitoring of lithium levels as possible temporary rise in its level.

Analogs Mikardisa

Most are available Mikardisa following analogues: Praytor . Telmista . Hipotel .

Babies

The drug is banned for use in patients under 18 years.

During pregnancy (and lactation)

Prohibited use in pregnant and lactating women.

Reviews Mikardise

Reviews Mikardise characterized by a small number of reports of side effects, but most of the patients complained of its high price.

Price Mikardisa

In Russia, the packaging of the drug 80 mg №28 will cost from 830 to 980 rubles. In Ukraine, the price Mikardisa in the same form of release is approaching 411 UAH.