Description overdue on 07/21/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use tablets Valz (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Medicament comprising valsartan   (active ingredient), as well as additional ingredients: talc, microcrystalline cellulose, croscarmellose sodium, lactose monohydrate, povidone K29-32, magnesium stearate, silicon dioxide.

Product form

The drug is available in the form of yellow tablets (40 mg), which are covered with a film coating. Biconvex tablet, are oval in shape, on the one hand - the engraving «V», on the other side - the side risks. Also available pink tablets (80 mg, 160 mg).

The tablets are packaged in blisters 7 pc., In a cardboard box - 4 blisters.

Pharmacological action

Antihypertensive agents, peripheral vasodilator. The drug is a blocker of AT1-receptors of angiotensin II, does not inhibit ACE. Under influence valsartan It does not change the content of total triglycerides, LDL, glucose, and uric acid in the blood.

After two hours, maximum - four to six hours after the official beginning of his actions. The effect is maintained for one day. With regular treatment of drug maximum values ​​decrease Blood Pressure observed after 2-4 weeks. If there was a sudden interruption of treatment, withdrawal symptoms are not observed.

Pharmacodynamics and pharmacokinetics

After the drug was ingested Valz, it celebrated its fast absorption, while the extent of absorption is variable. The average bioavailability is 23%. There linear pharmacokinetics of valsartan.

In the active substance - a high level of binding blood proteins : This figure is 94-97%. When valsartan is used repeatedly, the kinetic parameters are not changed. When receiving a one-time medication daily observed a slight accumulation of valsartan.

The plasma concentration observed small-hydroxy inactive metabolite.

After oral administration of 83% of active substance exits the body through the intestine in bile, and 13%, mostly unchanged eliminated via the kidneys.

Indications

Indications Valz following means:

• arterial hypertension ;
• chronic form Heart Failure   (part of the complex treatment);
• an increase in the survival rate of survivors of acute myocardial infarction   (from 12 h after infarction until 10 days).

Contraindications

Do not use Valz for treatment in such cases:

• disorders of the liver, which occurred due to obstruction of the biliary tract;
• severe degree of renal insufficiency, including the period of Hemodialysis ;
• pregnancy and breast;
• patient age of 18 years;
• malabsorption of glucose and galactose, galactosemia Lactose intolerance;
• intolerance to the ingredients of the drug.

Valz to use caution when hypotension . obstructive hypertrophic cardiomyopathy . hyperkalemia . hyponatremia , Primary hyperaldosteronism renal artery stenosis, aortic and mitral stenosis.

Side effects

In the course of drug treatment may experience the following side effects:

• Cardiovascular system : orthostatic hypotension , Manifestations Heart Failure In rare cases - vasculitis . bleeding .
• Respiratory system : Progress cough .
• Digestive system : diarrhea In rare cases - nausea .
• Hearing : vertigo .
• CNS : insomnia . depression . dizziness . fainting , Reduction of sexual desire, in rare cases - neuralgia . headache .
• Hematopoietic system : neutropenia In rare cases - thrombocytopenia .
• Allergic symptoms : High sensitivity; in rare cases - rash . itch . swelling .
• Musculoskeletal system : convulsions , Pain in the back, myalgia . arthritis In rare cases - arthralgia .
• Metabolism : hyperkalemia .
• The urinary system : In rare cases - a violation of the kidneys.
• Viral infections.
• The decline in Hemoglobin   and hematocrit . hyperbilirubinemia . hypercreatininemia , Increase in liver transaminases.
• Fatigue, epistaxis, fatigue.

Instructions for use tablets Valz (method and dosage)

Before you take the tablets Valz, instruction on the use of funds must always be studied in detail by the patient.

Instructions for use Valz 80 mg provides that it is a means of the recommended dose. Patients with hypertension initially shown the intake 80 mg once a day.

The drug must be taken orally, regardless of mealtime.

Once the patient began taking the drug, hypotensive effects seen in the first 2 weeks of taking drugs. The greatest effect was seen at four weeks after initiation of therapy. If the tablets in a daily dose of 80 mg did not exert the expected effects, the daily dose Valza increased to 160 mg.

During the treatment the patient may be given a different antihypertensive medication such as a diuretic.

If the patient is diagnosed with a chronic form of heart failure, initially it is assigned a two-time welcome Valza 40 mg. If the effect is insufficient, the dose is gradually increased up to 80 mg twice a day. If the treatment is well tolerated by man, the dose can be increased to 160 mg two times a day. From the start of therapy until the time when a transition to a maximum dose must be not less than two weeks.

Most Valz daily dose - 320 mg, the dose is divided into two steps. When concomitantly with a diuretic dose can be reduced.

If a person moved myocardial infarction And hemodynamic stable therapy begins during the twelve hours following acute myocardial infarction.

Reception begins with a dose of 20 mg twice a day, it gradually increased up to 40 mg, further - 80 mg, and the end of the third month of treatment already, the dose is 160 mg, divided in two stages. Increasing the dose should take into account the portability of the drug.

Overdose

If an overdose, a person may experience a strong decline in blood pressure. In this state, and possible loss of consciousness collapse .

Urgently needed gastric lavage followed by activated charcoal is shown. With an overdose of intravenously 0.9% sodium chloride solution. Dialysis valsartan is not displayed.

Cooperation

Taking pills Valz 80 mg dose of the drug to another, it should be noted that the expression of interaction with other drugs is not marked.

However, if the patient is assigned to the pressure pills Valz, while it takes other antihypertensive drugs and diuretics, antihypertensive effect of valsartan may increase.

The risk of hyperkalemia is celebrated while taking tablets and Valz potassium-sparing diuretics . potassium products , Agents that enhance the potassium content of the blood plasma.

When taken with NSAIDs   reduced antihypertensive effect.

There is information about the toxic effects and reversible increase in the concentration of lithium in the blood plasma in the treatment Valz and ACE inhibitors.

There is not enough experience with valsartan in conjunction with lithium-containing medicines . In this case it is necessary to control the concentration of lithium in the blood plasma.

You can combine Valz and other drugs used for the treatment of heart failure. You do not need to apply at the same time Valz and ACE-inhibitors + beta-blocker.

Terms of sale

Implemented by prescription.

Storage conditions

Valz should be stored at an air temperature not higher than 30 ° C. Protect medicine from children.

Shelf life

Keep Valz can be 3 years.

Cautions

Before treatment tablets Valz need to restore the level of electrolytes and fluids. To do this you need to reduce the dose of diuretics.

If the patient says renovascular hypertension , Is necessary to ensure continuous monitoring of performance creatinine   and urea in the blood.

In the treatment and means Valz chronic heart failure   at the beginning of the treatment of blood pressure can be reduced, so the importance of its permanent control.

When treating drug may experience changes in the kidneys.

During the course of treatment should be carefully means to drive vehicles and engage in other activities that require attention and concentration.

Analogs Valza

By analogues Valza active substance - it medicaments Valsafors . Diovan . Valsartan . Tantordio . Valsacor . Zentiva . Nortivan . Tareg .

Analogs of the drug on the mechanism of its effects - it means Aprovel . Bloktran . Brozaar . Zisakar . Irsar . Losartan . Kardost . Footmen . Makleodz . Teveten   and etc.

The price depends on the analog preparation.

Babies

Not applicable for the treatment of children and adolescents under 18 years of age.

With alcohol

Alcohol enhances the hypotensive influence means Valz.

During pregnancy and lactation

There are no clear data on the use during pregnancy and lactation. The higher the risk to the developing fetus notes while taking the drug in the second and third trimesters. If the patient has been established pregnancy, you should immediately stop taking the tablets Valz. Lactation during treatment according to drug should be suspended.

Reviews Valze

Reviews of doctors and patients about Valze indicate that the drug pressure is an effective way to reduce high blood pressure. Valz Tablets 80 mg with proper administration and dosage can reduce blood pressure, improve the general condition of the patient. In a review of Valze also noted that the sudden suspension of the drug is not the so-called withdrawal.

Price Valz where to buy

Valz Tablets 40 mg (28 pcs. Pack) will cost an average of 150 rubles. Price Valz 80 mg from 200 to 250 rubles. Price Valz 160 mg pharmaceutical networks in different ranges from 270 to 300 rubles.