Description overdue on 08/19/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Active ingredients - Valsartan   + Hydrochlorothiazide.

Additional ingredients:

• povidone;
• microcrystalline cellulose;
• silica colloidal anhydrous;
• lactose monohydrate;
• magnesium stearate;
• talc;
• croscarmellose sodium.

Product form

The drug enters the pharmaceutical market in the form of film coated tablets.

Here are a combination of doses of active ingredients of the drug - Valsartan   (B) + Hydrochlorothiazide   (T).

• B - 80 mg + T - 12, 5 mg, Tab. n / a in the package number 30, № 90;
• B - 160 mg + D - 12 5 mg Table. n / a in the package number 30, № 90;
• B - 160 mg + D - 25 mg Table. n / a in the package number 30, № 90;
• B - 320 mg + D - 12 5 mg Table. n / a in the package number 30;
• B - 320 mg + D - 25 mg Table. n / a in the package number 30.

Pharmacological action

Hypotensive (antihypertensive).

Pharmacodynamics and pharmacokinetics

Vazario H is a combined drug (medicament) for the treatment of hypertension . Valsartan - angiotensin II receptor blocker Acting solely on receptors that are responsible for a ngiotenzin II. He actively participates in the regulation of cardiovascular function , Wherein without blocking and without binding other hormone receptors or ion channels.

Hydrochlorothiazide   - thiazide diuretic   (a diuretic) is antihypertensive agents Which reduces renal reabsorption of electrolytes   and increases the excretion chlorine, sodium, potassium, bicarbonate, magnesium   and water as well as increases the content Renin   in blood plasma.

The combination of these two agents provides a more pronounced hypotensive effect Than their use alone.

Valsartan   rapidly absorbed from the gastrointestinal tract, the extent of absorption is variable. The absolute bioavailability - 23%. Plasma protein binding occurs at 94-97%. Intestinal excretion occurs mainly (83%) and kidneys (13%) largely unaltered.

Hydrochlorothiazide   also has rapid absorption. Tmax is reached in about 120 minutes. The bioavailability at the level of 60-80%. T1 / 2 ranges from 6 to 15 hours. Excreted by the kidneys by 95% unchanged and as metabolites by 4%, so the pharmacokinetics Hydrochlorothiazide   largely depends on the renal function.

Systemic bioavailability Hydrochlorothiazide   when co-administered with Valsartan   It decreased by about 30%. On the other hand, combining the use of Hydrochlorothiazide   It has no significant effect on the pharmacokinetics Valsartan . This reaction does not affect the efficiency Vazario H, but rather marked antihypertensive effect of the combination that exceeds the effect of each drug alone.

Indications

The drug Vasari H used for the treatment of conditions associated with hypertension.

Contraindications

• hypersensitivity to any component of the drug substance;
• heavy pathology of the liver;
• cholestasis and cirrhosis of the liver;
• anuria;
• Refractory hypokalaemia;
• heavy   pathology of renal function;
• hypercalcemia;
• hyponatremia;
• symptomatic hyperuricaemia;
• hypersensitivity to other sulfonamides.

Side effects

On the side Valsartan   often manifests itself:

• orthostatic hypotension;
• infectious diseases of the upper respiratory tract, including pharyngitis and sinusitis;

Rarely:

• neuralgia;
• hypotension;
• conjunctivitis;
• cough;
• heart failure;
• diarrhea;
• nose bleed;
• pain in the abdomen;
• back pain;
• asthenia;
• myalgia;
• weakness;
• arthritis;
• hyperkalemia;
• sleeplessness;
• syncope;
• Depression.

Rarely:

• headache;
• thrombocytopenia;
• rashes and itching;
• bleeding;
• angioedema;
• impairment of renal function;
• arthralgia;
• gastroenteritis;
• vasculitis;
• rhinitis.

On the side Hydrochlorothiazide   sometimes possible:

• hyperuricemia;
• hypokalemia;
• orthostatic hypotension;
• increasing the lipid content in the blood;
• arrhythmia;
• jaundice;
• pancreatitis;
• pulmonary edema;
• pneumonitis.

Instructions for use (method and dosage)

Instructions on Vasari H involves taking pills orally, washed down with a small amount of water, regardless of meals.

Instructions for use Vasari H 80 mg / 12 mg 5 recommends this as a daily dose.

When failure of the dose for 3 - 4 weeks considering further treatment in a daily dose of 160 mg / 12 mg 5.

Vasari H 160 mg / 25 mg is indicated for patients with little decrease in blood pressure in the previous dose.

Subsequently, if necessary, possibly a gradual increase in the dose of the drug to a daily dose of 320 mg / 12 mg 5.

The maximum daily dose Vasari H 320 mg / 25 mg.

Stable effect of the drug Vasari H achieved within 2-4 weeks.

Overdose

Admission dose Valsartan Exceeding the maximum recommended may contribute to severe hypotension That may cause heart failure and / or shock.

Overdose Hydrochlorothiazide   can lead to nausea, drowsiness, hypovolemia, electrolytic disorders Affecting muscle spasms and arrhythmia .

Recommend gastric lavage and administration of saline solutions. Dialysis is not effective.

Cooperation

The joint appointment of preparations and products containing potassium Should be careful and watch out for concentration Potassium   in blood.

Parallel reception Glibenclamide, cimetidine, indomethacin, atenolol, furosemide, digoxin, warfarin, hydrochlorothiazide, amlodipine   It does not lead to significant interaction with Vasari N.

Other means of treatment of hypertension may enhance the antihypertensive effect Valsartan.

Prolonged therapy with NSAIDs   may reduce the hypotensive and diuretic effects of the drug and lead to a violation renal function.

Admission Vasari N may affect glucose tolerance, requiring dose adjustment hypoglycemic   drugs.

Metformin   from Hydrochlorothiazide   should be used with caution because of the possible development of lactic acidosis.

In appointing Methyldopa   there may be cases of hemolytic anemia.

Simultaneous reception thiazide diuretics It may lead to increased hypoglycemic effects Diazoxide,   side effects of Amantadine,   increase sensitivity Allopurinol And reduce urinary excretion of cytotoxic drugs ( Methotrexate, cyclophosphamide   etc.) and an increase in their myelosuppressive action.

In a joint reception with holinoblokatorami ( Atropine, Biperiden ) Increased bioavailability Hydrochlorothiazide.

Kolestiramin   reduces the absorption of Hydrochlorothiazide.

Cyclosporine   Vasari and N increase the risk of hyperuricemia   and development symptoms of type podagraticheskih.

Terms of sale

Prescription.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

4 years.

Cautions

With the utmost care appoint patients with cirrhosis, heart failure, myocardial infarction, with bilateral renal artery stenosis In combination with ACE inhibitors , While taking drugs Potassium and potassium-sparing diuretics.

When QA & gt; 30 ml / min dose adjustment is required.

For patients with neholestaticheskim liver   dose should not exceed 80 mg Valsartan.

Analogs

• Mikardis Plus;
• Kardosal Plus;
• Olimestra H;
• Teveten Plus;
• Losap Plus;
• H Lorista etc.

Synonyms

• Valsacor H;
• Valzap Plus;
• DioCore;
• H Sakord etc.

Babies

There is no reliable information on the use of H Vasari in childhood.

During pregnancy (and lactation)

Not applicable.

Reviews

Vasari H appeared in the pharmaceutical market relatively recently, but has already established itself as a highly effective remedy for hypertension   with minimal side effects.

Of course, that adequate therapy can be administered only by an experienced doctor after a thorough examination and under constant surveillance.

Price Vasari H, where to buy

Price Vazario H Russian varies depending on the dosage and the number of tablets in the package, in the range 200 - 600 rubles.