Description overdue on 08/19/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The active ingredient is   Valsartan.

As additional ingredients are present:

• microcrystalline cellulose;
• silica colloidal anhydrous;
• lactose monohydrate;
• povidone;
• magnesium stearate;
• talc;
• croscarmellose sodium.

Product form

Available in the form of tablets of 40 mg, 80 mg, 160 mg and 320 mg Valsartan.

One package may contain from 30 to 90 tablets.

Pharmacological action

Hypotensive (antihypertensive).

Pharmacodynamics and pharmacokinetics

Valsartan   It is an active drug substance, and refers to the group receptor blockers angiotensin I I. selectively acting on receptors responsible for Angiotensin II, regulates cardiovascular function without blocking and without binding other hormonal receptors   or ion channels.

The antihypertensive action of valsartan is already apparent after 120 minutes after administration of a single dose and reaches a maximum for 4-6 hours. The hypotensive effect of a single dose is continued for 24 hours. When everyday taking full stabilization Blood Pressure   observed within 2-4 weeks and remains in such indicators throughout the further course of therapy.

With the lack of effectiveness prescribed Vasari Vasari H, hypotensive effect, which is much higher, due to the presence in its composition Hydrochlorothiazide.   Actually this is the difference between Vasari Vasari and N.

Discontinuation of therapy does not lead to Vasari withdrawal syndrome . There is a small cumulation   Repeated dose of the drug.

Following oral administration, tablets Vasari well and rapidly absorbed from the gastrointestinal tract.

The absolute bioavailability is 23%.

The plasma protein is bound by 94 - 97%.

Excreted unaltered through the intestine (83%) and kidneys (13%).

Indications

The drug is used for treatment of Vasari hypertension And pathologies of the cardiovascular system, which are accompanied by symptoms chronic heart failure.

Contraindications

• severe liver disease, including cirrhosis;
• violation of the outflow of bile;
• pregnancy and lactation;
• impaired renal function, including holding   hemodialysis;
• hypersensitivity Valsartan   or other components of the drug.

Side effects

• arthritis;
• sinusitis;
• back pain;
• sore throat;
• cough;
• orthostatic hypotension;
• conjunctivitis;
• hypotension;
• dyspeptic disorders (abdominal pain, diarrhea );
• myalgia;
• heart failure;
• asthenia;
• syncope;
• sleeplessness;
• neuralgia;
• depression;
• bleeding of different localization;
• angioedema;
• acute renal failure;
• gastroenteritis.

Instructions for use (method and dosage)

The drug Vasari, for convenience purposes, is available in different dosage from 80 mg to 320 mg. Due to the severity of the disease and the individual characteristics of the recommended intake of the drug with a different active ingredient content.

Instructions on Vasari 160 mg   It recommends this dose as the average daily therapeutic dose of the drug for the treatment of hypertension . As indicated, after failure of the dose, it can be increased to a maximum dose - 320 mg, taken once or twice a day. Preparation Vazario 160 mg can be combined with other antihypertensive drugs.

At CHF (congestive heart failure)   Disposable medicament initial dose is 40 mg - 40 mg one tablet or half a tablet of 80 mg. The next dose can be 80 mg - 1 tablet of 80 mg or the application of a dose of 160 mg half tablet Vasari, instructions for use of the drug Vasari 80 mg   It recommends a gradual increase of the dose to a single dose of 160 mg.

Single dose of twice a day (morning and evening) to achieve maximum effect. Then, depending on the tolerability of the drug, it produces an adjustment to the minimum effective dose. Do not exceed the maximum recommended daily dose of 320 mg.

At myocardial infarction .   in his post-MI, the initial single dose Valsartan   of 20 mg (tablet 40 mg bisection), twice a day. For several weeks following the initial dose can be increased up to a maximum single dose - 160 mg twice a day.

Vasari tablets taken orally (inside) with water. Eating does not affect the timing of the doses. The duration of the therapeutic course may be determined only doctor.

Overdose

With an overdose of the drug may develop hypotension,   accompanied by dizziness.

Patients are advised to take a horizontal position and conduct the parenteral administration of saline solutions.

Because of the significant binding Valsartan   Plasma protein appointment Dialysis   not effective.

Cooperation

Concurrent use with Vasari potassium-sparing diuretics , Preparations   Potassium   or drug increases its concentration requires special care and control over content Potassium   in blood.

In a joint reception and Vasari Glibenclamide, cimetidine, indomethacin, atenolol, furosemide, digoxin, warfarin, hydrochlorothiazide, amlodipine   they are not observed clinically significant interaction.

Appointment of other antihypertensive drugs may lead to increased antihypertensive effect   Valsartan.

Combines reception NSAIDs   causes a decrease in the hypotensive action and may contribute to reversible renal function impairment. In some cases, in patients with impaired renal function and in elderly patients may develop acute renal failure.

Terms of sale

Vasari drug prescription.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

4 years.

Cautions

Vasari requires careful preparation to patients with appointments renal artery stenosis And in the case of parallel application potassium-sparing diuretics   and preparations potassium.

Taking large doses diuretics   drugs can lead to symptomatic hypotension Due to reduction of blood volume and the level of sodium.

At the initial stage of therapy CHF At cirrhosis of the liver,   at post-MI , Simultaneous reception ACE inhibitors   Vasari should be prescribed with extreme caution and under constant medical supervision.

When liver pathologies daily dose Valsartan   should not exceed 80 mg.

Analogs

• Mikardis;
• Losap;
• Lorista;
• Teveten;
• Kardosal;
• Kandesar   etc.

Synonyms

• Valz;
• Valsacor;
• Diovan;
• Valaar;
• Tareg;
• Nortivan   etc.

Babies

Vasari Application for the treatment of patients in children and adolescents has not been studied.

During pregnancy (and lactation)

Contraindicated for use in pregnancy and lactation.

Reviews

Reviews of preparation Vasari, in the treatment of diseases Cardiovascular They carry a positive tone, saying his choice for the treatment of these disease states.

Naturally, the Vasari prescribed the drug, like other medicines, can only be experienced doctor.

Reviews Vasari 160 mg For the treatment of hypertension,   mostly positive, as in the full-dose, and at the reception and even the half-quarter pill, which is associated with the individual drug tolerance and disease severity. The undoubted advantage of the drug find its high efficiency, if possible once a day administration.

Price Vasari, where to buy

Price tablets Vasari is very diverse depending on the region, the mass of the active substance and the number of tablets.

For example, the price of Vasari 80 mg №30 Moscow fluctuating from 240 to 350 rubles.