Description overdue on 19.06.2012

Antihypertensives . Main components: dihydralazine, reserpine . The latter is the sympatholytic and penetrates from presynaptic terminals synaptic postganglionic fiber, which leads to the release norepinephrine   vesicles, and also violated his return transport, strengthens the inactivation of MAO. Reserpine causes a persistent drop in blood pressure, leading to depletion of the neurotransmitter, helping to reduce serotonin, dopamine   and other neurotransmitters in neurons, causing an antipsychotic effect. The drug increases, enhances physiological sleep, keeps the activity of the parasympathetic nervous system, reduces peripheral vascular resistance, heart rate, reduces the effects of the sympathetic innervation of the cardiovascular system, inhibits interoretseptivnye reflexes slow down the metabolic processes in the body increases the production of hydrochloric acid in the stomach, increases peristalsis, ugulublyaet slows breathing and movement, reduces the intensity of metabolic and metabolic causes hypothermia , Cramps. In patients with hypertension, coronary atherosclerosis Adelfan has positive effects on protein, lipid metabolism, increases the glomerular filtration improves renal blood flow . In the treatment of drug hydralazine prevents reflex tachycardia. Stable effect is recorded by the third week of therapy. Digidralazin able to reduce smooth muscle tone of the arterioles, reducing resistance in the blood vessels of the heart, kidneys, brain, improve blood flow. Adelfan comes in tablet form.

Indications, contraindications:

Adelfan prescribed for hypertension. The drug is not used during electroconvulsive therapy in Parkinson's disease, depression, intolerance digidralazina, reserpine, when pheochromocytoma , Epilepsy, ulcerative colitis, thyrotoxicosis, constrictive pericarditis, aortic stenosis, heart failure at high IOC with ulcers of the digestive system, tachycardia, MAO inhibitors, breastfeeding, acute myocardial infarction, pediatric, breastfeeding, expressed pathology kidney and liver. When sinus bradycardia, cerebral arteriosclerosis, coronary atherosclerosis, heart failure, with diabetes , Cholelithiasis, erosive gastritis , Intraventricular block, the elderly, ulcerative disease of the digestive system in the history of post-myocardial infarction Adelfan used with caution.

Side effect:

Side effects of reserpine: hyperptyalism , Dry mouth, gastrointestinal bleeding, vomiting, ulcerative lesions of the gastrointestinal tract, nausea, increased secretion of gastric juice, arrhythmias, edema, sinus bradycardia , Dizziness, cerebrovascular disease, angina, fainting, "tides" of blood to the face, orthostatic hypotension , Extrapyramidal disorder, "nightmarish" dreams, irritability, headache, Parkinson's disease, cerebral edema, anxiety, attention deficit disorder, disorientation, stupor, shortness of breath, swelling of the lining of the nose, abnormal ejaculation, decreased libido, glomerulonephritis, dysuria, bleeding from the nose, gynecomastia , Galactorrhea, prolactin disorders, weight gain, blurred vision, tearing, thrombocytopenia, anemia, purpura, pruritus, eczema , Hearing impairment. Side effects digidralazina: allergic reactions, hepatitis, jaundice, vomiting, increased liver enzymes, nausea, dyspepsia, swelling, a drop in blood pressure, "tides" of blood to the face, heart palpitations, tachycardia . peripheral neuritis , Irritability, disturbance of appetite, dizziness, thrombocytopenia, anemia, weakness, weight loss, arthralgia , Fever, volchanochnopdobny syndrome.

Overdose:

Manifested extrapyramidal disorders , Confusion, dizziness, headaches, a fall in blood pressure, myasthenia , Depression of the respiratory center, arrhythmia, angina, myocardial ischemia, collapse , Tachycardia, vomiting, cramps, nausea, coma, convulsions. Requires gastric lavage, the appointment of enterosorbents, the introduction of vasoactive drugs, plasma-solutions. In convulsions diazepam administered, diarrhea - anticholinergic medicines, in the case of respiratory depression mechanical ventilation. Patients were followed for three days.

Mode of application:

Adelfan taken 2-3 times daily, orally. Therapy is initiated with small dosages per day is not more than three tablets. If renal disease drug taking in minimal doses. The elderly, with severe renal pathology of a mandatory dose adjustment.

Special instructions:

When diagnosing fever , Arthralgia, depression, rashes on the skin Adelfanom therapy is stopped. When planning surgery medicament cancel a few days prior to surgery. Illegal assignment to ACE inhibitors . To prevent further recommended bradycardia atropine. When using medicines that contain adrenostimulyatorov, care must be taken. Adelfan affects the performance of hard work, the management of car.

Drug Interactions:

Other antihypertensive drugs can enhance the hypotensive effect Adelfan. The drug reduces the impact Morphine , Anticholinergics, antiparkinsonian . In combination with cardiac glycosides   part of the reserpine may cause arrhythmias, decreased heart rate. Adelfan with methyldopa causes depression. The drug enhances the central effects of antihistamines, ethanol-containing, sleeping pills, tricyclic antidepressants, barbiturates. In the appointment of MAO inhibitors, there is an increase in blood pressure hyperreactivity. Etanolsoderzhaschie, antipsychotics , Tricyclic antidepressants, diazoxide increase the severity of the hypotensive effect of hydralazine sulfate.