Description overdue on 09/23/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Amprilana
• Contraindications
• Side effects
• Amprilan, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Active Ingredient - ramipril . Additional material :   pregelatinized starch, lactose monohydrate, sodium hydrogen fumarate and sodium croscarmellose. The composition of the tablets with a dosage of 5 mg and 10 mg is added a mixture of dyes.

Combined medication Amprilan ND   additionally contains hydrochlorothiazide, a diuretic effect. Composition: active ingredient 5 mg of ramipril and 25 mg of hydrochlorothiazide.

Combined preparation Amprilan NL   2 contains 5 mg of active ingredient ramipril + 12, 5 mg of the diuretic hydrochlorothiazide .

Product form

Formulation - pelletized. The drug is available in doses of 1.25, 2.5, 5, 10 mg blisters 7 tablets. Blisters are packed in cardboard boxes (3, 6, 9 pieces).

Pharmacological action

The drug has a vasodilatory (dilates blood vessels) hypotensive effects . The active ingredient belongs to the group ACE inhibitors .

Pharmacodynamics and pharmacokinetics

In blocking ACE reduces levels Angiotensin-2 Increases the activity of renin, enhanced action bradykinin aldosterone . Hemodynamic and antihypertensive effects of the drug provided by expanding the lumen of the vessel, reducing the PR. The drug has no effect on   cardiac rhythm . Long-term treatment can result in regression of left ventricular hypertrophy, which develops in hypertension . Reduction blood pressure   recorded 1-2 hours after taking the drug, hypotensive effect lasts hours.

Patients with Heart Failure   reduces the risk heart attacks , Sudden death, disease progression, reduced the number of hospitalizations and emergency numbers hypertensive crises . Patients with diabetes   decrease Reduced risk nephropathy . These effects occur regardless of the level of blood pressure.

• heart failure   (chronic);
• hypertonic disease ;
• Coronary artery disease hearts .

Indications for use in patients with diabetes : Nephropathy.

Contraindications

• hypersensitivity  
• heart disease   (mitral, aortic, combined);
• breast-feeding ;
• cardiomyopathy ;
• pathology of the renal system ;
• hyperaldosteronism ;
• pregnancy ;
• age 18 years.

Side effects

In most cases it registered sharp fall in blood pressure   syncope . migraine headaches , dry cough, bronchospasm , Skin rash, worsening gastritis and pancreatitis with increasing enzyme concentration, pain in joints and muscles.

arrhythmia , Palpitations, angina Raynaud's syndrome , Vasculitis, asthenic-depressive syndrome with a sleep disorder, and transient ischemic attack stroke . impotence , Disruption of the renal system with increasing concentration Creatine and urea   in urine allergic reactions , Changes in laboratory values ​​in the form of neutropenia erythropenia .

With the progression of the severity of side effects is recommended to consult your doctor and stop taking the drug during Amprilan.

Amprilan, instructions for use (method and dosage)

Ramipril appointed interior regardless of the meal. Tablets recommended drink sufficient volume of liquid. The drug is assigned a doctor who chooses adequate dose based on the patient's condition and tolerance of components. It is recommended to start taking Amprilana with low doses of 2.5 mg, with the possibility of increasing to the maximum numbers - 10 mg. The duration of the drug determined by the physician according to the complaint and the information carefully collected history.

Correction of the dose during treatment. Duration of treatment is not limited.

Overdose

Symptoms of an overdose of the drug is bradycardia   (slow heart rate), a sharp drop in blood pressure, shock   with acute renal failure. For urgent measures in overdose include gastric lavage   and timely application   enterosorbents And with the threat of shock, the introduction of drugs that increase blood pressure.

Cooperation

Vasopressor sympathomimetic , A group of non-steroidal anti-inflammatory drugs, corticosteroids can reduce the severity of the hypotensive effect raminiprila . Increase the hypotensive effect of antipsychotic drugs, antidepressant drugs. Not recommended combination with drugs Amprilana group lithium, gold, potassium-sparing diuretics, hypoglycemic agents, cytotoxic drugs, drugs potassium immunosuppressants.

Terms of sale

Prescription.

Storage conditions

The temperature is not above 25 degrees, out of reach of children.

Shelf life

3 years.

Analogs Amprilana

Pharmaceutical factory produce structural analogs Amprilana:

• Tritatse Aventis
• Pyramus   company Lek Poland
• Charter   Hungary Egis companies

Reviews Amprilane (overview)

The drug has proved itself as an effective tool in the treatment of heart failure of varying severity. hypertensive disease .

Depending on the dosage of the drug dispersion of prices ranging from 200 to 400 rubles. The drug is available in many drugstores of Moscow. Price Amprilana ND is 490 rubles.