Description overdue on 07/11/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Coronal
• Contraindications
• Side effects
• Instructions for use, Tablets Coronal (A method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

The product contains the active substance bisoprolol fumarate   in an amount of 5 mg or 10 mg, and additional ingredients ( microcrystalline cellulose, sodium lauryl sulfate, magnesium stearate, microcrystalline cellulose, corn starch, Hypromellose, colloidal silicon dioxide, Macrogol 400, E172, E171 ).

Product form

Coronal Tablets are pale yellow, round and convex, risk. The blisters 10 tablets in packs 1, 3, 6 and 10 blisters.

Pharmacological action

Selective beta-blockers .

Pharmacodynamics and pharmacokinetics

The drug has arrhythmic   impact antianginalnoe Decreases arterial pressure By reducing the formation of Cyclic AMP   from adenosine triphosphate . Endocellular current calcium ions   decreases, the processes of excitation and inhibition inhibited, decreased heart rate, decreased contractility infarction .

Thanks to beta2-adrenergic receptors   oppressed, increases activity alpha-adrenoreceptor . In this regard, in the first few days of use Coronal increases PR , But after a couple of days, it returns to its normal level.

In the treatment agent is an oppression renin-angiotensin system Sensitivity baroreceptors   returns to normal, and as a consequence, decreases minute volume of blood .

Due to the reduction in oxygen demand of the heart, because of the improvement myocardial perfusion   and elongation diastole , The drug has a strong and stable antianginal effects . The antiarrhythmic effect of the drug is associated with a set of the factors listed above, as well as the ability to reduce the rate of excitation sinus   and ectopic pacemakers .

Bisoprolol is very well absorbed into the bloodstream, it falls about 90% of the drug. Concentration reaches a maximum after 3 hours, communicates with the blood of about 30% of active ingredient, metabolized   primarily in the liver. Output is via the kidneys for 10-12 hours.

Indications Coronal

Indications for use of tablets is Coronal arterial hypertension . coronary artery disease   and angina .

It is also an indication for the use of Coronal considered sinus tachycardia ; arrythmia   (supraventricular and ventricular); prolapse ; arrhythmia Induced thyrotoxicosis .

The indications on the Coronal 5 mg may serve as prevention myocardial infarction   and minor cardiac arrhythmias.

Contraindications

Purpose and use of the drug is contraindicated in

• allergies   on the active ingredient or other components;
• sick sinus syndrome ;
• asthma ;
• cardiogenic   one form or another shock ;
• acute heart failure ;
• sinoartrialnoy blockade;
• strong bradycardia ;
• reduction   Blood Pressure   below 100 mm. Hg .;
• myocardial infarction ;
• AV blockade Especially second and third degree;
• at Raynaud's disease .

The drug is not indicated for children, lactating women.

The drug is not combined with reception MAO inhibitors, floctafenine, sultopride .

Side effects Coronal

The most common side effects are:

• dry mouth, diarrhea, nausea, constipation ;
• asthenia, drowsiness, depression , headache;
• bradycardia . angiospasm , Reduction Blood Pressure ;
• allergic reactions   skin, hyperemia ;
• arthralgia , Pain or cramps in the calf muscles.

It has been reported cases of agranulocytosis . potency disorders . thrombocytopenia , Withdrawal syndrome.

Instructions for use, Tablets Coronal (A method and dosage)

Tablets are taken in the morning, 20 minutes before breakfast, is not liquid and not divided.

According to the instructions for use Coronal 5 mg starting daily dosage of 2, 5 to 5 mg. Then, according to indications, the dosage can be increased to 10 mg. Max bisoprolol Received per day is 20 mg.

For patients with severe liver impairment in the kidney, the daily dosage should not exceed 10 mg.

Overdose

Symptoms of overdose are: bradycardia, arrhythmia, lowered blood pressure, acrocyanosis, dizziness, syncope, bronchospasm .

In case of overdose should be flushed stomach, take chelators , Means to relieve symptoms ( atropine, epinephrine, lidocaine, dopamine, dobutamine, glucagon, diazepam ).

Cooperation

Do not take with other beta-blockers .

With combined with caution iodine-containing contrast media . phenytoin . derivatives of hydrocarbons , Extracts of allergen skin test, nifedipine . coumarins . muscle relaxants, tricyclic antidepressants, neuroleptics . sedatives . ethanol .   MAO inhibitors .

When combined with Coronal lidocaine   and xanthines , Increased plasma concentrations of the latter.

Particular caution should be observed for diabetics, as influenced by drug effectiveness insulin may vary, and symptoms hypoglycemia   do not show.

Therapeutic drug effect attenuated in combination with NSAIDs . GCS . Estrogen .

Biosprolol affects the efficiency heart klikozidov . reserpine . guanfatsina . methyldopa . verapamil . diltiazem . Amiodarone .

Very much lower BP   can diuretics, clonidine   and hydralazine   in combination with a drug.

The combination and Coronal sulfasalazine   increases the concentration bisoprolol   in the blood plasma, and rimafmpitsin   It reduces the half-life of the drug.

Considered undesirable reception baclofen, amifostine, floktafanina, mefloquine, chloroquine, adrenaline, noradrenaline   and Coronal.

Terms of sale

Prescription.

Storage conditions

In the cool, hidden from children.

Shelf life

3 years.

Analogs Coronal

The closest analogue Coronal are: bikard, bisokard, bisoprolol, bisoprofar, dorez, Concor, kordinorm, CORBIS, bisostad, biprolol .

Other analogues of the drug: azoprol, metokor, atenol, atenolol, atenobene, Betacam, betalok, breviblok, korvitol, egilok, betakor, vazokardin, korvtol, lokren, metoprolol, metoprolol tartrate, nebivovol, nebikor, nebilong, nebitrend, tenolol .

With alcohol

Coronal and alcohol should not be combined, because of the risk of mutual reinforcement Sedation   and hypotensive effects.

Reviews Coronal

Reviews Coronal The drug helps, but often show side effects in the form of a strong downward pressure, weakness and dizziness. Many people drink it for several years, the condition does not worsen.

Price Coronal (where to buy)

Coronal Price for 30 pieces of 5 mg 121 ruble. The same amount of drug in a dosage of 10 mg costs approximately 209 rubles.