Description overdue on 06/27/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use of CRESTOR (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

One tablet contains 5, 10, 20 or 40 mg rosuvastatin Calcium   and additional substances ( monocrystalline cellulose, crospovidone, lactose monohydrate, calcium phosphate, hypromellose, E171, E172, glycerol triacetate, magnesium stearate ).

INN: rosuvastatin .

Product form

Round or oval (40 mg), film coated tablets of different colors, depending on the dosage.

Color: yellow (5 mg), pink (10, 20, 40 mg). On one side is engraved ZD4522 5, 10 ZD4522, ZD4522 20, respectively, the content of the active ingredient. For dosage of 40 mg, on the one hand written ZD4522, other - 40.

Cardboard packaging with a blister, 28 pieces in a pack. To 10 mg - 7, 28 or 98 tablets.

Pharmacological action

Hypolipidemic .

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug - a selective inhibitor of HMG-CoA reductase . Rosuvastatin   significantly reduces maintenance Lipoprotein   Low and very low density levels by increasing the number of hepatic receptors that respond to LDL . Thus, the accelerated catabolism   The trapping and low density lipoproteins in the liver, to suppress the formation of very low density lipoproteins.

Level cholesterol, triglycerides, apolipoprotein B, TG, VLDL, VLDL, LDL cholesterol   etc. decreases. The therapeutic effect is evident after 7 days of administration of drugs through 14 - reaches its maximum.

Maximum concentration in the blood - 5 hours, cumulation - in the liver. Good binds plasma proteins Almost completely (90%). About 10% active ingredient metabolized . Output is in the feces, and to a minor extent, through the kidneys. In patients with severely impaired liver function was observed in the change pharmacokinetic parameters .

Indications

The drug is used:

• as a preventive or therapeutic agent in the family homozygous hypercholesterolemia ;
• as part of comprehensive measures (diet, physical attack. load, weight loss) at mixed hypercholesterolemia ;
• treatment atherosclerosis ;
• as prophylaxis in predisposition cardiovascular diseases .

Contraindications

• severe liver disease, especially associated with higher levels transaminase ;
• breastfeeding and pregnancy;
• Patients taking cyclosporine ;
• myopathy At risk of developing myopathy reduce the dosage;
• children (under 18 years);
• allergy On which a component of the drug.

Side effects

• headache, polyneuropathy ;
• myopathy , Pain in muscles and joints;
• various allergic reactions ;
• nausea, pancreatitis, constipation, diarrhea ;
• asthenia ;
• tubular proteinuria .

Instructions for use of CRESTOR (method and dosage)

Tablets are taken regardless of meals, without breaking or chewing.

The dosage and duration of the medication should be administered by your doctor.

According to the instructions for use of Crestor, the first receiving the drug and patients with a low demand for it, the daily dose set in the range of 5-10 mg. After 21 days, if necessary, the dosage can be increased. By increasing the daily intake of 40 mg of Crestor to, should closely monitor the condition of the patient, especially in the first few days of transition to a new dosage.

In patients with moderate renal impairment, a starting dose is 5 mg per day. Next - up to 40 mg / day.

For Mongoloids, as a result of the functioning of the liver, the initial dose is 5 mg per day. Contraindicated assignment and receiving doses greater than 20 mg per day.

In persons who are prone to myopathy   appoint more 20 mg daily is contraindicated.

Overdose

In case of overdose side effects are amplified. Hemodialysis   inefficient, no specific antidote.

Therapy - according to the signs + control liver enzymes .

Cooperation

Do not combine with cyclosporine .

There is a change in the plasma concentrations of CRESTOR in combination with other lipid-lowering drugs   ( gemifibrozil ).

The drug affects the value prothrombin index In relation to this, it is not recommended to combine it with vitamin K antagonists . warfarin .

The incidence of adverse events and the character can be changed while taking rosuvastatin with ezetimibe .

Different fibrates gemofibraty, nicotinic acid   and gemfibrozil increase the likelihood of myopathy . Their combination with Krestorom not recommended.

Not Recommended simultaneously with the drug protease inhibitors, ritonavir, lopinavir, erythromycin, antacids, oral contraceptives and.

Terms of sale

Prescription.

Storage conditions

Keep out of the reach of children. Store in a cool place.

Shelf life

3 years.

Analogs of CRESTOR

Substitutes CRESTOR are: klivas, roviks, romazik, rozvator, rozukard, Roxer, fastrong, rozulip, rosuvastatin, Sandoz, rozart, Merten .

Crestor and analogs thereof: allesta, Astin, atorvasterol, atormak, vabadin, vazoklin, Vasto Soest, Lescol XL, torzaks, livostor, lipimaks, Lipitor, Lovastatin, simvakard, etset, Simgal, tolevas, torvakard, Tulip, torvazin, simstat, simvakor, pravapres, litorva, lipodemin, limistin, livazo, Denizli, Zocor, Vasilip, atoteks, Atoris, amvastan.

Price analogues may significantly differ from the original.

Reviews of Crestor

Reviews of Crestor on the forums a little. The drug appeared on the domestic market relatively recently. The medicine is used to treat active hyperlipidemia Especially in individuals who have suffered heart attacks   and strokes . Among the side effects you may experience headaches and impaired sleep. While receiving the funds should pay particular attention to the control over the composition of the blood and the level of liver enzymes.

Price CRESTOR where to buy

Buy in Moscow on 28 tablets of 5 mg may be for 972 rubles.

Price Crestor 10 mg in pharmacies is about 1537 rubles per 28 pieces. Price Crestor 20 mg of cholesterol is 2439 rubles per 20 pieces.

Buy tablets 40 mg, 28 pieces can be for 3656 rubles.