Description overdue on 17.06.2012

Antihypertensives . The main ingredient is lisinopril It refers to a group of ACE inhibitors. The mechanism of action is based on reducing the formation of angiotensin-2 of the angiotensin-1. The drug reduces the production of aldosterone, increases production prostaglandins It reduces the degradation of bradykinin preload reduces blood pressure. Diroton extends over an artery rather than a vein. Long-term therapy leads to a reduction in the severity   myocardial hypertrophy . The drug increases blood flow to the injured, ischemic myocardium. The drug slows the progression of left ventricular dysfunction after myocardial infarction and heart failure. Diroton begins its action after an hour. Available in the form of tablets.

Indications:

Diroton prescribed for hypertension, chronic Heart Failure . Lisinopril is indicated for use in the complex treatment of patients with the diagnosis - acute myocardial infarction. The drug is prescribed for diabetic retinopathy .

Contraindications:

Diroton not prescribed lisinopril intolerance, pregnancy, hypersensitivity to ACE inhibitors, breastfeeding. When idiopathic, hereditary angioedema , Coronary heart disease, cerebrovascular disease, aortic stenosis, coronary artery disease, inhibition of bone marrow hematopoiesis, connective tissue diseases, severe autoimmune disease, hyperkalemia, scleroderma, renal artery stenosis , Renal insufficiency system after renal transplantation, the elderly lisinopril administered with caution.

Side effect:

Cardiovascular system:   chest pain, arrhythmia, drop in blood pressure, tachycardia , Orthostatic hypotension. Nervous system:   muscle twitching limbs and mouth, drowsiness, fatigue, dizziness, headaches, confusion , Mood lability, asthenia. The digestive tract:   dry mouth, diarrhea, epigastric pain, taste perversion, anorexia, dyspepsia Nausea. Bodies of blood:   erythropenia, decreased hemoglobin levels, anemia, agranulocytosis, neutropenia . Perhaps the development of the allergic response, hyperkalemia, hyperbilirubinemia, hyperuricemia, reduced potency, dry cough, a developmental disorder of the kidneys in the fetus, arthralgia , Acute renal failure, myalgia, swelling of the lips, tongue and extremities, fever.

Mode of application:

In patients with hypertension Diroton taken orally, 5 mg once daily. In the absence of the desired effect to increase the dose of 5 mg every 2-3 days. At night no more than 80 mg. In heart failure drug begin to take two dosages, 5 mg, then increased every 3-5 days 2, 5 mg. In the elderly, the rate of excretion of lisinopril below, leading to longer hypotensive effect.

Special instructions:

Be particularly careful in the treatment of patients with bilateral renal artery stenosis or stenosis of the artery the only kidney in patients with decompensated form of chronic heart failure, with cerebrovascular disease . In patients with CHF drop in blood pressure can cause deterioration of the renal system. Data on the safety, efficacy Diroton have no children. Before using lisinopril obligatory compensation of loss of salts and fluids. When pregnancy Diroton can be used in the absence of the possibility of appointing other medicinal drugs.

Drug Interactions:

Diroton slows excretion of lithium preparations. Estroeny, NSAIDs, adrenostimulyatorov   reduce the severity of the hypotensive effects. When prescribing potassium potassium-sparing diuretics   may develop hyperkalemia.   Hypotensive effect is enhanced in combination therapy with diuretics, other antihypertensive agents, BCCI, beta-blockers. Kolestiramin, Antacids   reduce the absorption of lisinopril in the digestive system. The risk of pronounced inhibition of bone marrow hematopoiesis increases the appointment myelotoxic drugs .