Description overdue on 04/28/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications egilok
• Contraindications
• Side effects
• Instructions for use egilok
• Overdose
• Use of drugs Egilok with other medical drugs
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Tablets of 25, 50, 100, 200 mg.

Per tablet Egilok, Egilok Retard for 25, 50, 100 mg of the active substance ( metoprolol tartrate ) Respectively.

Per tablet Egilok C., active ingredient (metoprolol succinate ) falls 23.75, 47.5, 95, 190 mg, respectively, .

Excipients for Egilok, Egilok Retard: povidone . sodium carboxymethyl , Magnesium stearate, microcrystalline cellulose, colloidal anhydrous silica.

Excipients for Egilok C: ethylcellulose, microcrystalline cellulose, corn starch, methyl cellulose, glycerol, magnesium stearate.

Product form

Packed in a cardboard box 1, 2 and 3 blister, 10 pcs. each for 25 mg, 50 mg, 100 mg, 200 mg tablets.

Packaged in a bottle of dark glass 30 and 60 pieces. to 25 mg, 50 mg and 100 mg tablets.

Egilok

Round biconvex white or nearly white. Without smell. Amount: 25 mg, 50 mg, 100 mg.

• Per tablet Egilok 25 mg   on one side of the dividing line crosspoint double bevel on the other side engraving E435.
• Per tablet Egilok 50 mg   on one side of risk on the other side engraving E434.
• Per tablet Egilok 100 mg   on one side of risk on the other side engraving E432.

Egilok Retard

Biconvex tablets White round shape on both sides of risk. Volume 50 mg and 100 mg.

With Egilok

Biconvex tablets in the white membrane shell oval. On both sides of the risk. Amount: 25 mg, 50 mg, 100 mg, 200 mg.

Pharmacological action

Develops hypotensive, antiarrhythmic, antianginal and beta1-adrenoceptor blocking stimulation. It causes a rapid decrease in heart muscle contractions.

When sinus tachycardia   on the background hyperthyroidism   and functional problems with heart, as well as atrial fibrillation   and supraventricular tachycardia   medication can significantly slow down the heart rate up to the restoration of sinus rhythm.

In contrast, non-selective beta-blockers effect metoprolol   on carbohydrate metabolism and insulin production is less significant.

Pharmacodynamics and pharmacokinetics

The drug has a high rate of assimilation in the digestive tract. Within 1.5-2 hours after ingestion Cmax is achieved in the blood plasma. Under the influence of the active substance suppressed the increased activity of the sympathetic system in relation to the heart. From what pills Egilok with regular use causes lowering cholesterol   in serum. The bioavailability of the drug is increased by 30-40%, if you take metoprolol   together with food.

On the assimilation and elimination of the active substance impaired kidney and liver function influence virtually no effect. However, in patients with severe liver dysfunction ( cirrhosis . cash portacaval shunt ) Significantly increases the bioavailability, while chronic renal failure   and increased risk of unwanted side effects. In old age, the pharmacokinetics of drugs does not give significant changes.

After use, the drug passes the full extent of absorbency. Egilok has weak binding to proteins in plasma (less than 10%). The drug is excreted from the body mainly as metabolites, only 5% is excreted by the kidneys.

Indications egilok

• preventive warning of attacks migraine ;
• high blood pressure;
• Impaired functional cardiac activity;
• angina ;
• cardiac arrhythmias (supraventricular tachycardia and bradycardia during ventricular arrhythmia and atrial febrilyatsii);
• myocardial infarction .

Indications pills also apply to people over 60 years.

Contraindications

• SSS;
• cardiogenic shock ;
• expressed bradycardia   (less than 50 beats per minute);
• lactation period ;
• simultaneous reception of MAO inhibitors;
• age 18 years;
• hypersensitivity to the drug in particular, a beta-blocker at all;
• sinoatrial block;
• severely impaired peripheral circulation;
• bronchial asthma   in the severe form;
• AB - blockade 2 or 3 degrees.

Side effects

• In relation to the central nervous system: increased threshold fatigue (very common), headaches, dizziness   (common); infrequently - convulsions , Weakening of attention, depression, reinforced heart failure Nightmares; rarely - nervous excitability, anxiety . sexual dysfunction . hallucinations , Memory impairment.
• With respect to the sensory organs (rare) blurred vision .
• With regard to the digestive system (rare) stomach ache . diarrhea . constipation Dryness of mucous membranes in the oral cavity.
• With respect to the respiratory system: dyspnea on exertion (often) rhinitis   (rarely).
• With respect to the skin (uncommon): rash . increased sweating .

Instructions for use egilok

The tablets are taken orally, washed down with a little water. Admission is permitted both during the meal (recommended), and on an empty stomach.

Instructions on Egilok Retard   and Egilok : The dose is divided in two steps a day, morning and evening.

Instructions on With Egilok : Take one time a day, in the morning.

How to make (final size of the dose and the number of receptions) medicine doctor determined individually. The maximum dose of 200 mg. If the kidney function and elderly redistribution of volumes consumed drugs are not required.

• Heart failure   compensation at 25 mg per day.
• Hyperthyroidism :   50-200 mg per day.
• Arrhythmia :   50-200 mg per day.
• Angina pectoris :   50 mg per day.
• Migraine attacks   (prophylaxis): 100-200 mg per day.
• Tachycardia :   50-200 mg per day.
• Myocardial infarction   (secondary prevention): 200 mg per day.

Overdose

Redundancy and inconsistent use of the drug with a doctor implies an overdose, the most obvious symptom of which is the response of the cardiovascular system: slowing of heart rate, heart failure. In some cases, using drugs by persons under the age of 18 years is also possible negative reaction from the central nervous system: fatigue, the occurrence of seizures, excessive sweating, the onset of fatigue.

Common symptoms are: apnea . disturbance of consciousness . tremor . bronchospasm . vomiting . hyperkalemia   or hyperglycemia , Worsening of renal activity, asystole , Marked from Reductions in blood pressure.

In case of overdose for 20-120 minutes there is one or more of the above symptoms, depending on the characteristics of the organism. High concentration metoprolol   in the body depending on the nature of the symptoms persists gastric lavage, symptomatic therapy, the purpose adsorbent, atropine sulfate . gluconate . Dopamine . norepinephrine .

Use of drugs Egilok with other medical drugs

The list of prohibited drugs to the simultaneous use of a wide egilok. Therefore, special care should be to combine the drug with outside medicine.

When mixed with verapamil   It can cause cardiac arrest.

When mixed with beta-blockers ( Estrogens . theophylline . Indomethacin ) Reduced antihypertensive metoprolol property.

When mixed with ethanol is amplified pressurizing effect on the CNS.

When mixed with oral hypoglycemic agents and insulin   increases the probability of occurrence hypoglycemia .

When mixed with barbiturates   ( pentobarbital ) Under the influence of enzyme induction accelerated the metabolism of metoprolol.

Terms of sale

Egilok available on medical prescription.

Storage conditions

Egilok . Egilok Retard   It is stored at a temperature of from 15 to 25 degrees.

With Egilok   stored at temperatures up to 30 degrees.

Shelf life

Egilok Retard . Egilok : 5 years.

With Egilok : 3 years.

Analogs egilok

In cardioselective β-adrenergic blocker (INN: metoprolol) provided similar in effect on the body counterparts. These include: Betalok, Vazokardin, Korvitol, Lidalok, Metozok, Metokard, Metolol, Emzok, metoprolol . However, it should be understood drug analogues can not always fully replace originally designated recipe. Therefore, the replacement of the drug on a similar drug, be sure to consult a cardiologist.

Concor or Egilok - which is better?

The exact answer can only be given for individual examination. In general, however, it has several Konkor fewer side effects than egilok and its use at a low pulse to a greater extent permissible. Egilok has a stronger effect on the drug compared with Concor.

Egilok and alcohol

Drug interactions with alcohol-containing substances implies a sharp decrease in blood pressure , Which in turn may lead to cerebral hypoxia . So, there may be: weakness . dizziness . loss of consciousness . In the case of lack of medical care and a strong concentration in the body of metoprolol and alcohol, depletion of energy resources in the brain, which can lead to tragic consequences.

Egilok during pregnancy and lactation

In the absence of comprehensive information on medical research conducted on the effects of metoprolol on the embryo, may be the inclusion of the drug in the treatment period only one case where a benefit to the pregnant patient is considered higher risk of harm to the fetus.

However, the drug is often used during pregnancy, but in any case in the first trimester or during lactation and breastfeeding baby . The size of the dose and frequency determined by the adoption of a strictly individual. Among try out the drug has reviews during pregnancy. As a rule, those women who followed the doctor's recommendations, during the course of taking the medicine, did not experience discomfort, but on the contrary, their cardiovascular condition improves.

Reviews on Egilok

Given the fact that the drug is one of the most popular drugs in the group, there are a lot of responses, it is as reviews of doctors Egilok Retard and reviews from ordinary users who publish their opinions on the Internet. To find reviews of the tablets, it is enough to visit the Forum on pharmaceuticals. According to the majority, the drug can often cause temporary fatigue in the early stages of reception, but at the same time great fights with rapid pulse, rapid slowing it down. In addition, during the course seen slowing motor reactions, and therefore the driving and control of potentially dangerous machinery should be careful.

Price Egilok where to buy

Average price Egilok Retard Established in Moscow pharmacies: 215 and 275 rubles. per pack of 30 pieces. 50 mg and 100 mg tablets.

Average price Egilok   Moscow: 125 and 150 rubles. 25 and 50 mg tablets in an amount of 60 units. in the bank.

The average price for With Egilok   Moscow: 175, 215, 275 rubles. per pack of 30 pieces. 25, 50, 200 mg tablets.