Description overdue on 06/27/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications kardiket
• Contraindications
• Side effects
• Instructions for use kardiket (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

One tablet Kardiket Retard 20, 40 and 60 contain isosorbide dinitrate   20, 40 and 60 mg, respectively. Also includes additional substances ( talc, polyvinyl acetate, monohydrate lactose, potato starch, magnesium stearate ).

INN: isosorbide dinitrate .

Product form

The drug release in the form of white round tablets. Depending on the dosage, on the one flat side is pushed risk engraved and IR 20, 40, or IR 60 IR. On the other hand more convex - inscription SCHWARZ PHARMA.

The blisters 10 pcs, are cartons 1 or 5, that is, 20 or 50 tablets prolonged action in each package.

Pharmacological action

Vazodilatirtee .

Pharmacodynamics and pharmacokinetics

The active substance leads to relaxation smooth muscle of the vessel walls Thus, expanding peripheral veins   and artery   and producing vasodilator effect . Diastolic blood pressure is lowered, a reverse return of venous blood into the ventricle decreases as its volume content.

After taking the pill, its effect occurs rapidly (within 15 minutes). Bioavailability - 22%, degree of binding with squirrels - 30%. Main metabolites Produced in the liver: isosorbide-2-mononitrate .   isosorbitol-5-mononitrate Their output is through the kidneys. Completely out of the day.

Indications kardiket

From what is prescribed the pill?

For prophylaxis and treatment anginal attacks . myocardial infarction . coronary heart disease .

It is also an indication for use is kardiket heart failure   (chronic), in combination with other drugs.

Contraindications

• drug allergy ;
• vascular collapse   and   shock ;
• much lower blood pressure ;
• diseases and conditions associated with increased intracranial or intraocular pressure ( glaucoma );
• acute myocardial infarction and hemorrhagic stroke ;
• stenosis ;
• head trauma;
• a decrease in blood volume;
• mix with inhibitors of phosphodiesterase type 5 ( tadalafil, sildenafil, vardenafil ).

Use of the drug is not recommended, or must take place under the supervision of a physician

• children up to 18 years;
• at cardiac tamponade;
• pronounced anemia ;
• toxic pulmonary edema ;
• hypertrophic obstructive cardiomyopathy ;
• at constrictive pericarditis ;
• chronically low BP ;
• hyperthyroidism ;
• severe kidney and liver.

Side effects

• weakness, decreased BP . angina   and bradycardia , headache;
• slowness of response, drowsiness . ischemia ;
• dryness of the mouth, belching, nausea, stomach pain;
• facial flushing, allergic rashes   skin, nitrate tolerance to other drugs.

Instructions for use kardiket (method and dosage)

The dosage and mode of reception Kardiket Retard should appoint an expert. Tablets do not chew, wash down with water.

According to the instructions on the Application of kardiket, the daily dose may be from 60 up to 80 mg, the distributable on the 1-3 reception. At a dosage of 20 mg, appoint 1 table. Two times a day. Generally, treatment is initiated with smaller doses, and it is gradually increased. We do not recommend sharp throwing the reception means.

Overdose

Loss of consciousness, collapse , Nausea, diarrhea . anoxia . coma . respiration , Redness of the skin. Treatment: enter 1% methylene blue   intravenously, 2 mg per kg body weight of the victim.

Cooperation

With combined with caution vasodilators, calcium channel blockers, tricyclic antidepressants, alcohol-blockers, antihypertensives, antipsychotics, quinidine, novokainamidom, dihydroergotamine, tadalafil, sildenafil   and Vardenafil .

When used with simpatomimetikami   and Alpha-blockers , Antianginal effect of the drug is reduced. Directly affect the efficiency of drug preparations enveloping stomach as reduce the permeation rate of active ingredient into the systemic circulation from the stomach.

Atropine   and others M-holinoblokatory   may increase the risk of rising intraocular pressure.

Kardiket could and should be combined with nifedipine . Pananginum . amiodarone . Riboxinum   and propranolol .

Terms of sale

Prescription.

Storage conditions

In a dark, cool place, out of reach of children.

Shelf life

5 years.

Analogs kardiket

The closest: dikor Long nitrosorbid, Izodinit, izoket, iso-mic .

Other analogues kardiket: mononitrosid, nitro, nitrogranulong, nitro-mic, nitrosprey, Erin monokontin odes monosan, nitroglycerin, nitrokontin, Nitromintum, Olikard retard Efoksa Long .

Reviews kardiket

Reviews kardiket mostly positive. It is often prescribed for people with diseases and disorders of the heart. Because of the side effects most commonly occur headaches, and there are reports of very severe headaches. In any case, the drug effectively adjusts the heart muscle, regardless of the specific reaction of the organism as a side effect.

Price kardiket where to buy

The cost of 20 tablets of 20 mg about 65 rubles. Price Kardiket 20 mg for 50 tablets - of the order of 137 rubles.

Purchase Kardiket Retard   40 mg may be for 104 rubles - 20 pieces, 209 rubles - 50 pieces.

60 mg of the drug will have to pay 143 rubles for 20 pieces, 363 rubles - 50 pieces.