Description overdue on 17.05.2012

Blocker alpha and beta adrenergic receptors. The active substance is   Carvedilol . Korvazan has antianginal, antiarrhythmic and vasodilating effects. As a result of vasodilation, reduced peripheral vascular resistance. Vasodilating effects   provided by blocking alpha 1 adrenergic receptors. Korvazan slightly uryazhaetsya pulse. Patients with coronary artery disease has antianginal effects, and reduces post-preload on the heart. The drug has no effect on the lipid metabolism, the content of magnesium, sodium, potassium in the blood plasma. In patients with heart failure, left ventricular hypertrophy drug improves the ejection fraction, the size of the heart chambers, a positive effect on hemodynamic parameters. Korvazan eliminate oxygen free radicals, antioxidant effect . In patients with decompensated form of chronic heart failure drug reduces the incidence of hospitalization, the risk of death. The highest efficacy is observed in patients with low ejection fraction, tachycardia. Korvazan is available in tablet form.

Indications:

Korvazan used in heart failure, angina, hypertension.

Contraindications:

Korvazan not prescribed for atrioventricular block 2-3 degrees of intolerance to carvedilol, bronchial asthma, breastfeeding, cardiogenic shock , Bradycardia, liver pathology system, pregnancy. Precautions drug used in decompensated heart failure, chronic bronchitis , Bronchospastic syndrome, diabetes, Prinzmetal angina , Thyrotoxicosis, hypoglycemia, pheochromocytoma , Peripheral vascular occlusions, psoriasis, myasthenia gravis, depression.

Side effect:

Nervous system:   myasthenia gravis, dizziness, paresthesia , Depression, sleep disorders, dizziness, unconsciousness, headaches. Cardiovascular system:   the progression of heart failure, angina pectoris, atrioventricular block, orthostatic hypotension , Bradycardia, intermittent claudication . Digestive system:   vomiting, increased liver enzyme system, epigastric pain, nausea, dry mouth, constipation Diarrhea. Bodies of blood:   leukopenia, thrombocytopenia . Urinary system:   severe renal pathology system. Perhaps the development of allergic reactions, pain in the limbs, gippopodobnogo syndrome, weight gain, dyspnea, bronchospasm, sneezing , Exacerbation of psoriasis.

Overdose:

The marked drop in blood pressure, cardiac arrest, cardiogenic shock, heart failure, impairment of respiratory function. It requires the use of cardiotonics, control over the work of the cardiovascular system.

Mode of application:

Korvazan taken orally. Hypertension: the first two days at 12, 5 mg daily, after which the dose is doubled. Angina: Daily 12, 5mg.

Special instructions:

Korvazan prescribed with caution in patients whose work involves rapid psychomotor reactions. Abolition of the drug produced gradually. Storing the tablets Korvazan to light results in a change of color. Taking medication can lead to asymptomatic hypoglycemia , Thyrotoxicosis. In pediatric patients the drug is not used. During therapy requires a complete rejection of the receiving alcoholic beverages.

Drug Interactions:

Korvazan increases the impact of sulfonylureas, insulin , Antihypertensive agents. At reception diltiazem , Antiarrhythmic agents, verapamil drug is prescribed with caution. Carvedilol increases in blood levels of digoxin. Against the background of general anesthetics marked hypotensive and negative effects of nootropic. Rifampicin , Phenobarbital lower drug levels in the blood, accelerating its metabolism. ACE inhibitors, diuretics, cimetidine and other inhibitors of microsomal oxidation increase the hypotensive effects Korvazana.