Description overdue on 06/27/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Lerkamena (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

A tablet containing 10 or 20 mg lercanidipine hydrochloride .

Additional components: K30, povidone, lactose monohydrate, sodium carboxymethyl cellulose, magnesium stearate. Each tablet is covered with a special membrane, which includes: iron oxide, titanium dioxide, talc, macrogol and Opadry.

Product form

The drug is available only in tablet form. Doses of the medicament 10 and 20 mg of active substance. The blister may contain 7 or 10 tablets. The number of tablets in a cardboard bundle 7, 14, 28, 35, 42, 50, 56, 60, 90, 98 or 100 units.

Pharmacological action

The tablets have a pronounced hypotensive effect . The mechanism of action is based on the selective blocking of the calcium receptor. Lercanidipine is able to slow down the flow of calcium ions into smooth muscle, and cardiomyocytes.

Lerkamen 20   reduces the total peripheral vascular resistance   and gradually expand the lumen of blood vessels, preventing the development of reflex tachycardia   and collapse . The drug does not have a negative inotropic effect.

Pharmacodynamics and pharmacokinetics

Medicine Lerkamen 10   well absorbed in the digestive system. The maximum plasma concentration   recorded after 1, 5-3 hours. The plasma protein binds to 98% of active ingredient.

The bioavailability of the drug increases after a meal, which is why it is recommended to take the pills on an empty stomach. With increasing doses there is an increase Bioavailability . Initially, medication metabolized   in the hepatic system, which explains the low absolute bioavailability - 10%.

The hypotensive effect was observed during the day. The active ingredient is derived through the renal system; half-life of 10 hours.

Indications

Lercanidipine administered to patients suffering from essential form hypertension   (severity: mild to moderate).

Contraindications

• heart failure ;
• obstruction of blood vessels, leaving the left ventricle;
• individual hypersensitivity to lercanidipine ;
• lactase deficiency;
• pregnancy;
• unstable form of angina pectoris;
• acute myocardial infarction;
• sick sinus syndrome   (patients without pacemaker);
• lactation;
• age limit - 18 years.

Side effects

Nervous system:

• migraine;
• dizziness;
• disorders of sleep and wakefulness.

The digestive tract:

• violations of the chair;
• gastralgia;
• dyspepsia   (nausea, vomiting);
• increase in ALT, AST;
• violation of digestion.

Cardiovascular system:

• discomfort in the chest;
• heart palpitations ;
• increase in angina attacks;
• drop in blood pressure;
• chest pain .

Also, allergic responses, frequent urination, polyuria development, swelling, redness, gingival hyperplasia Pain in the muscles.

Instructions for use Lerkamena (method and dosage)

The tablets are intended for ingestion. Not allowed refinement of the drug, damage containment. The efficiency increases with the drug lercanidipine fasting. The duration of therapy is determined by the doctor.

Instructions for use Lerkamen 10:   take 1 tablet every 24 hours. With insufficient decrease in blood pressure after 14 days it is possible to switch to a single dose of 20 mg.

Instructions on Lerkamen 20:   pills washed down with water on an empty stomach. With increasing doses of medicament (20 mg per day) increased hypotensive effect was not observed, but the increase is recorded incidence and severity of undesirable side reactions.

With the ineffectiveness of the drug in the treatment of hypertension is recommended the appointment of additional antihypertensive drugs from other pharmacological groups.

Overdose

Marked fall in blood pressure,   drowsiness . ischemic changes   tissue infarction, nausea, development cardiogenic shock . It is recommended that induction of vomiting, laxatives appointment, enterosorbents . In severe intoxication prescribe dopamine, catecholamines, diuretics. Perhaps the development of atropine bradycardia , Fall in blood pressure and loss of consciousness. Treatment is carried out in a hospital. Hemodialysis   not proved its effectiveness.

Cooperation

The absorption of the drug is enhanced by the treatment midazolam . CYP3A4 inducers, ethanol, cyclosporine   and grapefruit juice while taking absolutely contraindicated Lerkamena.

Caution is required when taking high doses cimetidine (more than 800mg).

The bioavailability of the active agent increases simultaneously with increased negative inotropic effect in the treatment beta-blockers .

It requires a mandatory dose adjustment Digoxin   after the start of therapy lercanidipine .

To reduce the risk of negative interactions is necessary to maintain the 10-hour window at reception simvastatin   and lercanidipine.

Terms of sale

Without medical prescription form.

Storage conditions

Temperature - not exceeding 25 degrees.

Shelf life

3 years.

Cautions

The drug can affect the speed of psychomotor reactions.

Analogs Lerkamena (substitutes)

Structural replacer sold in Russia - Zanidip Rekordati   (Italy). Analogs Lerkamena issued and assigned in other countries: Lerkaton . Lervask . Zanikor . Reviews analogues positive and indicate a high efficacy in the treatment of hypertension.

During pregnancy and lactation

Lerkamen contraindicated in pregnant women, during lactation.

Reviews Lerkamene (overview)

Portals and medical forums where patients share their impressions of taking medication, contain only positive feedback.

Reviews on Lerkamen 10 :   the drug is well tolerated and pressure stabilizes after 2 weeks of regular use in patients with hypertension, 1 st degree.

Reviews Lerkamene 20:   The incidence of adverse events is low, the medicament is considered highly effective in the treatment of hypertension 2, 3 degrees in combination with other antihypertensive agents.

Price Lerkamena where to buy

The cost varies depending on the region, a network of pharmacies.

Cost   Lerkamen 10   Moscow - 500 rubles (28 tablets).

Price   Lerkamen 20 mg   in the capital of Russia - 900 rubles (28 tablets).