Description overdue on 05/07/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Loristy H (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Reviews
• Price, where to buy

Composition

One tablet of the drug Lorista H   contains:

• 50 mg losartan potassium ;
• 12, 5 mg hydrochlorothiazide ;
• magnesium stearate, MCC, lactose monohydrate, pregelatinized starch.

The tablets of the drug Lorista ND   comprise:

• 100 mg losartan potassium ;
• 25 mg nidrohlortiziada ;
• magnesium stearate, MCC, lactose monohydrate, pregelatinized starch.

The shell consists of hypromellose , Quinoline dye (yellow), talc, Macrogol 4000, and titanium dioxide (E171).

Product form

Pills Lorista H   lenticular, oval, have yellow (in some cases with a greenish tinge) color, the risk on the one hand; Lorista ND   - Oval tablets having a lenticular shape, color from yellow to greenish, no scratches.

Pharmacological action

Renders hypotensive action .

Pharmacodynamics and pharmacokinetics

Both drugs (H and Lorista Lorista ND) are combined drugs with antihypertensive effect.

Losartan leads to increased activity of renin, as well as reduces plasma concentrations of aldosterone. Reduces round, the level of pressure in the pulmonary circulation, has a diuretic effect, reduces afterload.

Losartan prevents the emergence of myocardial hypertrophy It increases tolerance to physical exercise in those patients who suffer heart failure. Losartan reduces the pressure. There is no withdrawal , Has no effect on heart rate.

It is effective in individuals of either sex, as well as older people (over 65 years).

Hydrochlorothiazide has antihypertensive effect   thanks to the expansion of the arterioles. Effect after administration is achieved within 1-2 hours and the maximum is observed after 4 hours, it operates up to 12 hours. The hypotensive effect is achieved after taking 3-4 days, but in order to achieve the optimum effect it is necessary to 4 weeks.

When separate application pharmacokinetics hydrochlorothiazide   and losartan   It differs from that in the concomitant use.

Losartan is absorbed from the gastrointestinal tract. Serum is independent of the drug simultaneously with food. Bioavailability is at 33%. The maximum concentration observed after 60 minutes. About 35% of the drug is excreted through the kidneys, 58% - of bile.

Digestibility gidrohlorotiziada   after oral administration is 60-80%. Maximum concentration of from 1 hour to 5 hours. Rapidly excreted through the kidneys, since it is not metabolized.

Indications

Medicine Lorista H   and Lorista ND   have the same indications for use:

• reducing the risk of CVD ;
• reduction in mortality in patients with left ventricular hypertrophy and hypertension ;
• arterial hypertension   (combination therapy).

Contraindications

Both drugs should not be used in the following cases:

• anuria ;
• deficit Lactase ;
• hyperkalemia ;
• Refractory hypokalaemia ;
• renal failure or liver;
• galactosemia ;
• dehydration ;
• hypotension ;
• pregnancy;
• malabsorption of glucose or galactose;
• lactation;
• sensitivity to any component, sulfonamide derivatives;
• 18.

It should be used with caution in:

• diabetes ;
• bilateral renal artery stenosis ;
• disruption of water and electrolyte balance of the blood ( hypomagnesemia . hypochloraemic alkalosis . hyponatremia . hypokalemia );
• renal artery stenosis ;
• systemic blood diseases;
• hyperuricemia ;
• Allergic history;
• hypercalcemia ;
• gout ;
• asthma ;
• simultaneously with NSAIDs.

Side effects

A reception result of the drug may be the following side effects:

• dizziness   (non-systemic and systemic) insomnia . migraine , Headache, fatigue;
• palpitations, dose-related orthostatic hypotension, tachycardia In sharp cases - vasculitis ;
• cough, swelling of the nasal mucosa, pharyngitis , Respiratory tract infections (upper sections);
• nausea, abdominal pain, diarrhea , Vomiting, dyspepsia ; in rare cases - hepatitis, increased liver enzymes, bilirubin, functional disorders of the liver;
• back pain, arthralgia, myalgia ;
• Henoch-Schonlein purpura . anemia ;
• weakness, chest pain, asthenia , Peripheral edema;
• pruritus, anaphylactic reactions, hives , Angioedema.

Receiving this drug can also affect laboratory parameters : Hyperkalemia, increased levels of creatinine, urea, increased hematocrit and hemoglobin concentration.

Instructions for use Loristy H (method and dosage)

The drug is intended for oral administration. The combination with other drugs having anti-hypertensive effect. Taking the drug is independent of food intake.

With hypertension   A minimum dose - 1 tablet. After a three-week course is reached the maximum hypotensive effect. To achieve a stronger effect sufficiently taken once a day, 2 tablets, that is the maximum dose.

Patients with reduced BCC   should be taken per day to 25 mg of losartan. If the reduction of BCC occurred in patients receiving large doses of diuretics, then before starting therapy with Lorista H, you must stop taking diuretics.

The initial dose does not require adjustment in patients undergoing on dialysis,   suffering renal failure   (moderate) and   elderly patients (over 65 years).

The daily dose of losartan 50 mg appointed to reduce the risk of cardiovascular disease and mortality in patients who have a diagnosis of left ventricular hypertrophy or hypertension. If failed to reduce the pressure when receiving 50 mg, it is necessary to combine losartan   hydrochlorothiazide (12, 5 mg). If necessary, losartan can be increased to 100 mg, with no change in dose of hydrochlorothiazide. The maximum daily dose should not exceed a time of 2 tablets.

Instruction in the use of LP Loristy : This drug is given in the absence of therapeutic effect from the reception Loristy N. drug Lorista ND taken at the same daily dose as Lorista N.

Overdose

Overdose losartan   It has the following symptoms: a significant decrease in pressure, bradycardia . tachycardia . If you notice symptoms of overdose recommended treatment: symptomatic treatment, forced diuresis. Hemodialysis is ineffective in this case.

In case of overdose gidroholorotiazidom   can manifest symptoms: chloropenia . hypokalemia . hyponatremia . In this case assigned symptomatic treatment.

Cooperation

Clinically significant interaction with losartan digoxin . phenobarbital . hydrochlorothiazide . ketokonazolomvarfarinom . erythromycin   and cimetidine   not found.

The level of the active metabolite is reduced by losartan with rifampicin   and fluconazole . Thus clinically this interaction has not been investigated.

Hyperkalemia   may result from the combination with potassium-sparing diuretics ( triamterene . spironolactone . amiloride ), Potassium salts or additives containing potassium.

The efficacy of losartan may be reduced due to the reception NSAIDs   and selective COX-2 inhibitors .

Receiving Indomethacin   may reduce the hypotensive effect of lazortana .

Ethanol . drugs   and barbiturates   when combined with hydrochlorothiazide may cause the appearance of orthostatic hypotension.

The simultaneous adoption hypoglycemic agents   (including insulin ) May request correction of the dose.

An additive effect may occur when combined with other treatments antihypertensive agents .

Breaking the absorption of hydrochlorothiazide may be drugs such as colestipol   or kolestiramin .

Gidrohorotiazid   can enhance the effectiveness of muscle relaxants ( tudokurarin ).

Natriuretic, hypotensive and diuretic effect of hydrochlorothiazide may be reduced because of the adoption of NSAIDs (including COX-2 inhibitors).

Laboratory results of studying the functions of the parathyroid glands may be distorted because of the effect of hydrochlorothiazide on calcium metabolism.

Terms of sale

In pharmacies sold exclusively in the presence of a prescription.

Storage conditions

The drug should be stored in a dark, damp places are not. Maximum temperature - 30 ° C.

Shelf life

5 years.

Cautions

A combination with other antihypertensive drugs.

The initial dose for elderly patients is not specifically adjusted.

Admission hydrochlorothiazide may lead to increased hypotension   and disrupt water and electrolyte balance . As may be impaired glucose tolerance, decrease of urinary excretion of calcium, which in turn may result in a slight increase in the blood calcium level.

The drug in the II   or The III trimester   during pregnancy may cause fetal death. The drug should be discontinued in the event of pregnancy. A newborn or fetus may occur jaundice , Mother - thrombocytopenia .

The drug, most patients do not affect the ability to perform tasks requiring concentration. However, some patients in the early treatment can observe a significant reduction in pressure, dizziness. Before performing such work, it is necessary to assess the condition after taking the medicine.

Analogs

By analogues Loristy H include: angizar plus . Fort gizaar .   co-Centaur . Losap plus . lokard . Mr. nostasartan . tozaar-g .

All of these analogs also include a means Lorista ND.

Reviews Loriste H

The average score of the drug 4, 5 points (out of 5). Buyers say the effectiveness of the drug, its mild action. Among the shortcomings - the need to take each day and the side effects.

Positive feedback from doctors about the drug say its high efficiency. However, experts point out that it is necessary to take strictly defined doses doctor to reduce the risk of side effects.

Reviews on Loristu ND   coincide with the review of the Loriste H .

Price, where to buy

Cost Loristy ND   in Russia on average 350 rubles, Ukraine - 112 UAH.

Average price Loristu H   in Russia - 214 rubles, Ukraine - 114 UAH.