Description overdue on 03/07/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Merten
• Contraindications
• Side effects
• Instructions for use Merten
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Merten preparation composed of one tablet contains active substance rosuvastatin calcium   - 10, 4 mg and excipients: microcrystalline cellulose 12 . magnesium hydroxide . magnesium stearate . lactose monohydrate . crospovidone   (type A).

The composition of the coating film includes Opadry II White   (talc, titanium dioxide (E171), macrogol 3350, and polyvinyl alcohol).

Product form

Round and biconvex film coated tablet engraved with " C34 ". 10 pieces in one package Valium planimetric (3 pcs. In a carton box).

Pharmacological action

Lipid-lowering drugs for prevention and treatment atherosclerosis . Lowers cholesterol   low density lipoprotein cholesterol, and increases high-density lipoprotein.

Pharmacodynamics and pharmacokinetics

Tablets Merten is a selective and competitive inhibitor of the enzyme that converts HMG-CoA   at mevalonate . In the application it has a major effect, which carries out the synthesis of cholesterol and catabolism of LDL   (lepoproteinov low density). Binds to plasma proteins is approximately 90%. Metabolism   limited to - 10%.

Rosuvastatin calcium lowers total cholesterol and LDL cholesterol. The drug is excreted from the body naturally. His systemic exposure is increased in direct proportion to the dose received.

It is effective for the treatment of people with hypercholesterolemia Regardless of sex or age.

The maximum concentration of active substance in plasma is reached after approximately 5 hours after the appropriate dose. Bioavailability is about 20%.

The first effect of the drug is noticeable within a week. The maximum possible positive changes achieved after 1 month of receipt and supported for further use of the drug.

Indications Merten

Indications Merten may include the following:

• hypercholesterolemia ;
• combined dyslipidemic state ;
• hypertriglyceridemia   According to Fredrickson type IV;
• family homozygous hypercholesterolaemia ;
• Prevention and treatment atherosclerosis ;
• prevention of cardiovascular events ( heart attack . arterial revascularization . stroke   and so forth.).

The drug is often prescribed as an adjunct to dietetics When the very special diet and other lipid-lowering therapy techniques, such as exercise, are not enough.

Contraindications

Merten in tablets of 5, 10 and 20 mg is not recommended:

• pregnant women;
• during Lactation ;
• women of childbearing age who use unreliable contraceptives;
• at hepatic insufficiency ;
• when used with fibrates cyclosporine ;
• in the case of a lack of lactase and lactose intolerance;
• in functional problems with the kidneys;
• people with a predisposition to complications miotoksicheskim;
• when myopathy ;
• with high sensitivity and are hypersensitive to some components of the drug;
• when galactose malabsorption glucose .

Merten Tablets 40 mg forbidden to take when:

• hypothyroidism ;
• excessive use of alcohol;
• liver disease in active phase;
• personal or family history of diseases of muscle tissue.

These dosages are also not recommended for patients of Asian race.

Moreover, Merten cautiously prescribed for:

• metabolic, endocrine and electrolyte disorders, severe;
• uncontrolled epilepsy ;
• hypotension ;
• sepsis ;
• increased risk of the emergence and development myopathy ;
• history of liver disease;
• injuries;
• extensive surgical interventions.

It should also be prudent to make this tool for people older than 65 years. But its efficacy and safety for children have not been established.

Side effects

Common side effects Merten may be as follows:

• development Diabetes   Type II;
• asthenic syndrome ;
• dizziness ;
• constipation ;
• nausea;
• stomach ache;
• headache;
• myalgia .

In rare cases it may be rash , Pruritus, myopathy . rhabdomyolysis . pancreatitis . hives . And with regular admission tablets of 40 mg may develop myalgia . proteinuria   and myopathy . In addition, at this dose concentration may increase bilirubin   and glucose, as well as disrupt the thyroid gland.

In addition, if you are taking Merten, instructions for use indicates that in very rare cases may be arthralgia . jaundice . hepatitis . memory loss . breathlessness , Peripheral edema, diarrhea . gimaturiya . polyneuropathy . cough .

However, the side effects that may be caused by the use of Merten, as a rule, short-term or moderate. In many cases, they depend on the dosage of the drug. So the instructions for use should be observed strictly Merten.

When unexpected muscle pain or occurrence muscle weakness Which is accompanied by a general malaise and fever , Stop taking the drug and contact your doctor.

Instructions for use Merten

Take the drug can be at any time of the day inside with a little water. However, taking it necessarily should be combined with a diet, agreed with a specialist. The daily diet should consist of foods that are low in fat.

In each case, the dose of medication for the patient is chosen individually. First, it depends on the purpose of treatment. When adjusting dosages counted total cholesterol in each patient, and the risk of cardiovascular complications and possible side effects.

Minimal dosage is usually 5-10 mg per day. Gradually (but not earlier than a month), you can increase the dose. Tablets of 40 mg is better to take under constant medical supervision.

Overdose

In case of overdose symptomatic treatment. Hemodialysis is ineffective. It is important to monitor liver function and the degree of activity of CK.

Cooperation

Merten is very important to combine with other drugs. If you are taking:

• Cyclosporine   - AUC Merten (area under the curve " concentration-time ") Is increased by 7 times.
• Ezetimibe   - Change in the AUC and the concentration of both drugs. The probability of occurrence of adverse events.
• Protease inhibitors   - Possible extension of systemic effects Merten.
• Erythromycin   - Reduction of AUC _0-t   and C _max   Merten.
• Antagonists Vitamin K   - Possible increase in INR (international normalized ratio).
• Gemfibrozil   and other means of lowering lipid levels - increase by 2 times concentration and AUC values ​​Merten. Possible risk of myopathy. The simultaneous use of Merten tablets 40 mg and fibrates is prohibited. Dose rosuvastatin   should not exceed 5 mg.
• Antacids   - A suspension containing aluminum or magnesium hydroxide, can cause a decrease in concentration in the blood plasma Merten about half.
• Oral contraceptives   and Hormone Replacement Therapy   - Possible increase in AUC ethinyl estradiol   26% norgestrel   34%.
• Isozyme P450   - Will be a slight increase in AUC Merten.

Terms of sale

The drug is available only by prescription.

Storage conditions

Store tablets Merten need in dry and protected from direct sunlight. The temperature should be no higher than 30 ° C.

Shelf life

The drug is stored for 2 years.

Analogs Merten

Analogs Merten, components, ATC code and the form of that match:

• Klivas 10, 20 Klivas ;
• Crestor ;
• Roviks ;
• Rozart ;
• Rozvator ;
• Sandoz Rosuvastatin ;
• Rozukard 10 . Rozukard 20 . Rozukard 40 ;
• Rozulip ;
• Roxer ;
• Romazik ;
• Fastrong .

All of them are sold in a film coated tablet. The cost of a 10 mg tablet ranges on average from 65 to 150 USD.

Price analogues Merten code ATC 4th level of an average of 40 to 80 UAH.

Reviews Mertenile

The forums reviews of Mertenile mostly positive. Typically, the side effects it causes. The general state of health of patients taking pills cholesterol It is not impaired.

The experts, in turn, discuss whether it is justified by the use of statins, and what should be the dosage of the drug in each case.

Price Merten, where to buy

This tool is the only one in Russia rosuvastatin with a full range of dosages. Depending on the purpose of dosage, and the price will be different Merten.

Price Merten 10 mg in Ukraine on average 140 UAH., And in Russia - 700 rubles. The cost of pills with higher doses on average - 240 UAH. in Ukraine and 1100-1400 rubles. in Russia.