Description overdue on 03/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Niperten, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Depending on the form of the chemical composition of one tablet Nipertena (INN bisoprolol) can contain 2, 5 mg. 5 mg. or 10 mg. actively acting drug compound bisoprolol fumarate .

Povidone . magnesium stearate . carboxymethyl , and MCC   and colloidal silica (anhydrous)   It is part Nipertena as auxiliary substances.

The film coated tablets Nipertena contains titanium dioxide, Macrogol and talc.

Product form

The drug is released in the form of biconvex tablets nominal volume 2, 5 mg., 5 mg. and 10 mg., coated white light, on top of which is applied to one side of risk (on one side).

Pharmacological action

Niperten has hypotensive, beta-adrenoceptor blocking, antianginal , and antiarrhythmic   pharmacological effect.

Pharmacodynamics and pharmacokinetics

Inherently Niperten - it beta1-blocker Relating to the selectivity of the compounds, it does not possess its own without   sympathomimetic activity of membrane stabilizing properties . This medication helps to reduce the level   Renin   in the blood, as well as reduces the need myocardial oxygen .

The drug has a pronounced antiarrhythmic, antihypertensive and anti-anginal effects on the body. Thanks to its distinctive properties Niperten can affect the intensity of the   Calcium ion current   at the intracellular level, and blocks beta1-adrenergic receptors, formed in small doses heart Thus slowing down the process of education   cAMP (cyclic adenosine monophosphate) from ATP .

Antiarrhythmic   Nipertena effect is due to the ability of the drug to increase the number of cyclic   AMP As well as to eliminate such   arrhythmogenic factors as tachycardia . hypertension . increased activity of the nervous system . Under the influence of the need Nipertena infarction oxygen becomes smaller as a result of reduced contractility primary cardiac muscle and thereby attained antianginal drug effect .

Drug compound reaches the hypotensive effect of by reducing blood volume (1 min.), restoration of sensitivity (the result of effect on CNS   and reducing BP ), As well as through stimulation peripheral blood vessels . Under the influence of the active α-adrenergic receptors , As well as reducing stimulation β2-adrenergic receptors   in the first 24 hours after taking the drug increases PR (total peripheral vascular resistance).

However, after 3 days of performance back to normal, and prolonged therapeutic treatment - drop. It has been observed that, compared with similar drugs Niperten has a less pronounced effect on carbohydrate metabolism And such bodies contain in their tissues β2-adrenergic receptors , as: bronchi, pancreas, peripheral arteries, the uterus.

Drug compound is absorbed by 80-90%. About half the dose metabolized   with   liver   for 12 hours. Further kidneys   withdrawing approximately 98% of the activity of the active compound from the body.

Indications

What does the pill? Niperten shown at:

• hypertension;
• coronary heart disease;
• congestive heart failure;
• prevention of angina attacks.

Contraindications

Do not use the drug if:

• collapse;
• hypersensitivity to Beta-blockers   and other ingredients;
• pulmonary edema ;
• sinoatrial blockade ;
• bradycardia ;
• cardiomegaly ;
• sick sinus ;
• Prinzmetal angina ;
• asthma ;
• abuse peripheral circulation ;
• pheochromocytoma;
• AV blockade II-III degree .

Niperten is contraindicated in patients who have not reached 18 years of age. Everything else, especially attentive to the dosage and mode of administration of the drug should be treated in patients with diabetes , and   renal failure . thyrotoxicosis . psoriasis . myasthenia As well as the elderly.

Side effects

The use of the drug causes side effects such as:

• weakness, fatigue and dizziness;
• sleep disorders;
• headaches and memory impairment;
• hallucinations and depression;
• myasthenia gravis;
• convulsions;
• decreased vision;
• conjunctivitis;
• arrhythmia;
• Raynaud's syndrome;
• bradycardia;
• chest pain;
• nausea and vomiting;
• constipation or diarrhea;
• changes in taste;
• difficulty breathing;
• hyperglycemia in diabetes;
• hypoglycemia;
• hypothyroid state;
• skin rash;
• alopecia;
• leukopenia;
• thrombocytopenia;
• arthralgia;
• reduced potency;
• back pain.

Niperten, instructions for use (method and dosage)

In accordance with the instructions for use Nipertena, the drug is taken once daily on an empty stomach before breakfast. The dosage of the drug depends on the disease and condition of the patient. The recommended dosage of the drug in the 5 mg. It may be gradually increased up to 20 mg. per day.

Overdose

If overdose the following symptoms appear: bradycardia, arrhythmia, shortness of breath, cyanosis, dizziness, convulsions, fainting. If you notice the above symptoms the patient should consult a doctor immediately.

Cooperation

In order to avoid complications or side effects of the treatment Nipertenom should be avoided:

• allergens That are used in Immunotherapy ;
• iodinated contrast media to intravenous   drugs;
• phenytoin,   means for inhalation anesthesia ;
• antihypertensives ;
• Antidepressants . sedatives and tranquilizers   drugs;
• non-hydrogenated ergot alkaloids ;
• ergotamine ;
• antiarrhythmics .

Active action alters the effectiveness of the drug   insulin And also increases the blood concentration xanthine   and clearance of lidocaine .

Terms of sale

Leave a doctor's prescription.

Storage conditions

Niperten relates to medicaments from list B, and may be stored at temperatures not exceeding 30 ° C.

Shelf life

2 years.

Cautions

Patients undergoing treatment Nipertenom must be constantly monitored by medical staff. For elderly patients the level recommended by the studies of kidney function at least 1 time in 5 months. Doctors recommend patients to teach the technique of counting frequency heart rate   (a measure of heart rate), if necessary, so that they could control their own state.

Before the direct treatment of patients with bronchopulmonary history it is recommended to pass a comprehensive examination respiratory . The treatment may decrease the allocation tear fluid, it should take into account patients who use contact lenses.

Analogs Nipertena

The main counterparts Nipertena include drugs such as:

• Aritel;
• Bisokard;
• Biol;
• Bidop;
• Concor;
• Bisoprolol;
• Corbis;
• Tiresias;
• Coronal.

Synonyms

The international non-proprietary name (INN) Niperten

Babies

The drug is not recommended for use in patients under 18 years of age.

During pregnancy (and lactation)

The drug is not desirable to use during pregnancy   without urgent medical need. Breastfeeding during treatment Nipertenom should be discontinued.

Reviews Nipertene

Although people mostly leave positive feedback Nipertene, many say as a negative factor a large number of side effects of the drug.

Price Nipertena where to buy

The cost of the drug is dependent primarily on its nominal volume and the number of tablets in the package. Average price Nipertena (5 mg.) 30 tablets in a package does not exceed 150 rubles, and 100 tablets - 350 rubles.