Description overdue on 03.04.2012

Nonselective beta-blockers. The active component is sotalol . The drug has an antiarrhythmic, antianginal and hypotensive effects. The reduction of intracellular calcium is provided by blocking beta-adrenergic receptors, decreasing to stimulate the formation of cAMP from ATP by the action   catecholamines . The drug reduces myocardial contractility, inhibits excitability, conductivity, uryazhaetsya pulse. Due to sympathetic stimulation of peripheral blood vessels, reduce cardiac output, effects on the nervous system, restore the sensitivity of baroreceptors in the aortic arch, reducing the activity Renin-angiotensin system   hypotensive effect is achieved. Antianginal effect is a decrease in muscle needs heart of oxygen by pulse uryazheniya, reduce contractility. Clearing arrhythmogenic factors   (hypertension, tachycardia, the influence of the sympathetic nervous system) provides anti-arrhythmic effects. Sotaleks produced in the form of a solution in a tablet form.

Indications:

Sotaleks prescribed for supraventricular tachycardia , Spontaneous arrhythmias, ventricular arrhythmia, paroxysmal atrial fibrillation, WPW syndrome .

Contraindications:

Sotaleks not prescribed for cardiogenic shock , Atriventrikulyarnoy blockade, congestive heart failure, cardiomegaly, Prinzmetal angina , Hypotension, asthma, diabetes mellitus with ketoacidosis, breastfeeding, taking MAO inhibitors, metabolic acidosis. In psoriasis, pheochromocytoma, Raynaud's syndrome, liver failure, depression, elderly, hypokalemia, allergies, pregnancy, pediatric experts appointed after consultation.

Side effect:

Nervous system:   insomnia, depression, weakness, fatigue, headaches, anxiety, drowsiness, "nightmarish" dreams, hallucinations, paresthesia, myasthenia , Fatigue, short-term memory loss, tremors of the limbs. Senses:   reduced secretion of tear fluid, keratoconjunctivitis , Sore eyes, dry eyes, visual perception of the severity of a violation. Cardiovascular system:   arrhythmia, drop in blood pressure, atriventrikulyarnaya block, sinus bradycardia, weakening of myocardial contractility, orthostatic hypotension , Worsening of heart failure flow, conduction disturbances infarction, heart palpitations, symptoms vasoconstriction, chest pain, ventricular paroxysmal tachycardia. Digestive system:   taste disturbances, disturbances of the hepatic system, cholestasis, jaundice of the sclera, epigastric pain, dry mouth, nausea, vomiting. Respiratory system:   bronchospasm, laryngism , Rhinitis, nasal congestion, difficulty breathing. Endocrine system:   hypoglycemia, hypothyroid state, hyperglycemia in patients with insulin-dependent diabetes . Sotaleks can cause allergic reactions, alopecia, psoriasis, anemia, hemorrhage, exanthema, itching, changes in enzyme activity, reduced potency, weakening of libido, arthralgia , back pain. The drug affects the fetal development, causing bradycardia, hypoglycemia, developmental delay.

Overdose:

Manifests a pronounced drop in blood pressure, bradycardia, atrioventricular block, cyanosis of the hands and fingers, ventricular premature beats , Fainting, bronchospasm . Requires gastric lavage, atropine in violation atriventrikulyarnoy conductivity. In marked drop in blood of the patient is necessary to give the patient the Trendelenburg position.

Mode of application:

Sotaleks take vnuri administered intravenously. Tablets are washed down with water, do not chew. To achieve antianginal effect: twice a day to 80 mg. Hypertension: initially 80mg daily, then weekly dosage is increased by 80 mg; the drug can be administered once in a dose of 320 mg or more. Treatment of ventricular tachyarrhythmias: twice a day to 80 mg, the ineffectiveness Sotaleks taking thrice per day in the same dosage. Initially administered intravenously 20 mg, which corresponds to 2 ml of solution. Infusion produce slow control of ECG, blood pressure and heart rate is required. Patients with abnormal renal system Sotaleks drug is administered in small doses.

Special instructions:

The drug Sotaleks requires simultaneous control of blood pressure, pulse, ECG, blood sugar, kidney condition. If a patient stable angina   They estimate the number of attacks, tolerance to physical activity, the dose of nitroglycerin for relief of an attack. It requires use of the method of paired stress tests. In individuals with nicotine dependence efficacy of beta-blockers reduced. It should warn patients with contact lenses, that in the context of the therapy may reduce the production of tear fluid. Patients with pheochromocytoma   Sotaleks appointed after taking alpha-blockers. Intravenous infusions produce slow, mandatory monitoring of vital body functions. Sotalol is able to mask the clinical picture of hyperthyroidism. Perhaps increased symptoms in a sharp lifting of the drug in patients with thyrotoxicosis. With the development of depression in the background of the received sotalol therapy gradually stop. When pregnancy Sotaleks administered in life-threatening conditions of the mother. A similar situation during breastfeeding. At the time of receiving the treatment completely eliminate alcoholic beverages. Sotalol affects the brain, taking pictures, transportation management.

Drug Interactions:

Allergen extracts for skin tests, as well as allergens used for Immunotherapy   increases the risk of severe allergic reactions of a systemic nature with sotalol. The risk of developing anaphylactic reactions   increased by intravenous administration of radio-opaque, iodine-containing pharmaceuticals. Preparations for the common inhalation anesthesia, phenytoin   Intravenous administration can cause a fall in blood pressure, to increase the impact cardiodepressive. Sotaleks affect the effectiveness of oral hypoglycemic drugs, reduces the clearance of xanthine, lidocaine, theophylline. Preparations of NSAIDs weaken hypotensive effect. Antiarrhythmics, amiodarone, guanfacine, reserpine, methyldopa, cardiac glycosides   can cause heart failure, atrioventricular block, worsen over bradycardia . Simpatolitiki, clonidine, diuretics, hydralazine may cause a drop in blood pressure. Sotaleks prolongs the action of muscle relaxants, coumarin anticoagulants . Peripheral blood circulation can be broken at the same time receive a non-hydrogenated ergot alkaloids into the patient.