Description overdue on 11/18/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Vasilip (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The active ingredient of the drug - simvastatin .

Other components: starch, lactose monohydrate, MCC, anhydrous citric acid, talc, titanium dioxide, propylene glycol, magnesium stearate, butylhydroxyanisole, hypromellose, ascorbic acid .

Product form

The drug is sold in the form of film coated tablets. One package contains 14-28 pieces.

Pharmacological action

Lipid-lowering agents.

Pharmacodynamics and pharmacokinetics

This product is intended to reduce the level of cholesterol . It interferes with the synthesis cholesterol   liver cells. The drug reduces the total cholesterol . low-density lipoprotein   and triglycerides . It also decreases the content very low density lipoproteins   with some increase in the concentration of high-density lipoprotein .

In addition, the active substance improves Vasilip endothelial   vessels, slowing proliferation   and Cell migration at atherosclerotic   processes. He is a antioxidant .

Regulates content cholesterol   and his fractions   in the blood, as well as triglycerides   in people with hyperlipidemia . This means, moreover, slows development coronary atherosclerosis .

The active substance is absorbed in the digestive tract in the form of   lactone   ( metabolite ). On admission to the liver is converted to an active beta form gidroksikisluyu.

61-85% absorption of the drug. That portion of the drug that is not absorbed is excreted in the feces.

During the initial contact with the drug in the liver cells is cleaved roughly 79% of the active substance. The maximum content of the active metabolites It achieved after 65-180 minutes. Contact with the blood of 98%. The therapeutic effect is noticeable after 4-6 weeks.

Active ingredient is manifested mainly in the liver. Half-life metabolite   - Approximately 115 minutes. Excreted in the bile and urine.

Indications

Indications for use drugs are as follows:

• hypercholesterolemia ;
• need to reduce cardiovascular mortality in patients with atherosclerotic cardiovascular disease or Diabetes .

Contraindications

The drug should not be used when:

• acute liver disease;
• allergic reactions   one of the components;
• a steady increase in the level of transaminases   levels are not assigned genesis.

Side effects

Side effects may include:

• GI: constipation . dyspepsia , Nausea, diarrhea , Increased activity hepatic transaminases , Vomiting, abdominal pain, pancreatitis .
• Muscular system: muscular weakness , Pain in the muscles, myopathy   with increasing levels of CK . dermatimiozit .
• Vision: clouding of the lens.
• CNS: headache . depression . peripheral neuropathy . dizziness . insomnia .
• The bodies of the genitourinary system: infringement potency   and the kidneys.
• Allergies: rash, angioedema , Fever, eczema . itching . vasculitis , Redness of the skin.
• Laboratory indicators: increase ESR . eosinophilia . thrombocytopenia .
• Other: alopecia . photosensitization .

In rare cases, when there is Vasilip rhabdomyolysis   development renal failure .

Overall, the drug was well tolerated. Side effects are relatively rare, are not pronounced and pass quickly.

Instructions for use Vasilip (method and dosage)

Those who appointed Vasilip, instruction on the application reports that it adopted orally In the evening, 1 time per day.

A typical daily dose - 5-80 mg. As a rule, administered 10 mg. Dosage adjustment should be carried out with a minimum interval of 4 weeks. The daily dose should not exceed 80 mg. The maximum dose is prescribed only for people with severe hypercholesterolemia   or increased probability of occurrence cardiovascular complications . Instructions for use Vasilip reports that the course of treatment is determined by a specialist in each case individually, depending on what is, and indications for use as the patient tolerates the medicine.

When hypercholesterolemia   you need to lead a normal hypolipidemic diet   during treatment. Initial dosage in most cases - 10 mg. To significantly reduce the LDL cholesterol   Course you can start with 20-40 mg / day.

With Homozygous Familial Hypercholesterolemia   usually takes a day 40 mg or 80 mg, but at three doses (usually 20 mg in the morning and afternoon and 40 mg in the evening). It is desirable to combine the drug with another reception gipolipidemicheskogo facilities.

To prevent the development of cardiovascular disease in humans at increased risk CHD   administered from 20 to 40 mg / day. The dosage of the drug, choose an individual, is reduced if the level LDL less than 75 mg / dl and total cholesterol less than 140 mg / dl.

Vasilip may be used in conjunction with bile acid sequestrants . Patients who are being treated fibrates   or nicotinic acid, take initial dosage is 5 mg. The maximum daily dose should not exceed 10 mg. And when combined with Amiodarone   or Verapamil   Do not exceed the dose of 20 mg.

When expressed renal failure   better not to exceed the dose of 10 mg / day. If an increase in dosage is still necessary, the patient must be constantly monitored.

Overdose

Cases of severe overdose this tool has not been reported. As treatment is prescribed chelators , Control of the liver, the kidneys, the level of muscle creatine kinase blood fractions And gastric lavage. When rhabdomyolysis   with the risk of Acute renal failure   conduct hemodialysis .

Cooperation

Vasilip in combination with fibrates . Erythromycin . Itraconazole . Niacin . Cyclosporine , Nicotinic acid, Nefazodone   and Clarithromycin   increased risk of rhabdomyolysis   development renal failure . It is also possible if the simvastatin   at high dosages combined with Amiodarone   or Verapamil .

The content of active substance in the blood Vasilip when receiving Ritonavir .

Combination with Warfarin   amplifies anticoagulant properties . Thus, increasing the possibility of hemorrhagic complications .

Simvastatin   It may also improve D igoksina   in blood. Therefore, when this combination requires strict control of the patient by the specialists.

Terms of sale

Sold in the pharmacy network with a prescription.

Storage conditions

Optimum temperature 25 ° C.

Shelf life

The drug is stored for 3 years.

Analogs Vasilip

Analogs Vasilip pharmacies can be found the following:

• Vazoklin   (Vasocleen);
• Atorvakor   (Atorvacor);
• Tulip   (Tulip);
• Storvas   (Storvas);
• Livostor (Livostor).

All counterparts Vasilip have their own characteristics of application, so do not start their course without assigning specialist.

Reviews Vasilip

Reviews Vasilip indicate that the tool will be effective only if the appropriate diet. Its use can not be stopped without consulting with a specialist, even if the level cholesterol   I have returned to normal.

Positive reviews about Vasilip leave patients who received him in accordance with the doctor's recommendation and under his constant supervision. If necessary, the dosage should be adjusted so that it is a mandatory requirement.

Price Vasilip where to buy

The cost of the drug may vary depending on the form of. Price Vasilip in tablets of 10 mg, in the packing of 14 pieces - about 160 rubles, 28 pieces - 340 rubles.

The cost of the drug in tablets of 20 mg, in the packing of 14 pieces - about 230 rubles, 28 pieces - 450 rubles.

Price Vasilip in tablets of 40 mg, in the packing of 14 pieces - about 330 rubles, 28 pieces - 520 rubles.