Atacand

Description overdue on 12/12/2014

Latin name: Atacand
ATC code: C09CA06
Active substance: Atacand (Candesartan)
Manufacturer: ASTRAZENECA AB (Sweden)

Photos of the drug

Composition
Product form
Pharmacological action
Pharmacodynamics and pharmacokinetics
Indications
Contraindications
Side effects
Instructions for use Atacand (method and dosage)
Overdose
Cooperation
Terms of sale
Storage conditions
Shelf life
Cautions
Analogs
Babies
During pregnancy (and lactation)
Reviews
Price, where to buy

Atacand

Composition

One tablet of the drug Atacand contains 8, 16, 32 mg candesartan cilexetil .

Excipients: giproloza, calcium carboxymethyl cellulose, lactose monohydrate , Red dye ferric oxide, corn starch, magnesium stearate, macrogol .

Product form

Tablets Atacand is usually pink, biconvex, round, serif and pattern from one side.

14 tablets in a blister. Two blister packaging made of paper.

Pharmacological action

Angiotensin receptor antagonist 2 diabetes.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Atacand - An antagonist of angiotensin type 2 and, therefore, ntigipertonicheskim means . Blocks angiotensin type 1 receptors, which leads to the suppression of the effects of angiotensin second type (vasoconstrictive effect, stimulating aldosterone synthesis and cell growth, regulation of water and salt exchange). The antihypertensive effect due to a decrease in peripheral vascular resistance without increasing the heart rate.
The drug does not suppress angiotensin-converting enzyme . No effect on the other receptors or ion channels.

Pharmacokinetics

Maximum concentration in the blood occurs within 3, 5 hours. Binding interactions with blood proteins - 99.8%. A small portion of the drug (20-30%) is metabolized in the liver to release an inactive metabolite.

The half-life is 9 hours. Excreted by the kidneys and the bile. After single administration for three days displayed about 90% of the dose.

Indications

Hypertension .

Contraindications

Cholestasia or severe hepatic insufficiency .
Hypersensitivity to candesartan .
Pregnancy and lactation.

Side effects

From the nervous system: dizziness .
From the respiratory system: flu-like symptoms, cough . rhinitis, pharyngitis Increase the frequency of occurrence respiratory infections .
From the digestive system: abdominal pain .
From the circulatory system: swelling .
Other: lumbodynia .

Instructions for use Atacand (method and dosage)

Instructions for use Atacand prescribed to take the drug orally 1 time a day. Initial dose - 4 mg, standard - 8 mg, the maximum - 16 mg.

For people with liver or kidney initial dose - 2 mg.

Overdose

Symptoms: The main symptom is likely overdose will be dizziness and symptomatic hypotension . In a number of cases of overdose (intake to 672 mg) reported recovery without consequences.

Therapy: symptomatic, monitoring vital signs, prone position with raised legs. Sometimes needed infusion saline . Candesartan not output hemodialysis .

Cooperation

Clinically significant interactions with T idrohlorotiazidom, digoxin, warfarin, oral contraceptives, nifedipine, glibenclamide and E nalaprilom not found.

Significant interactions:

from potassium-sparing diuretics , Salt substitutes with potassium , Potassium supplements may increase the potassium content;
from lithium-containing agents May increase lithium content;
from NSAIDs there may be a reduction in antihypertensive effect , Increase the risk of kidney function, increase of potassium in the blood in patients with already impaired kidney function.