Description overdue on 25.10.2011

In its composition contains acetylsalicylic acid   (ASA) and magnesium hydroxide . Renders antiplatelet effect .

Aspirin is a well-studied antiaggregant , Which blocks the cyclooxygenase: is reduced the ability of of platelets to aggregation, rises fluidity and decreases blood viscosity. As a result, the vessel lumen and do not form occlusion clots reduces the risk of stroke   and heart attacks .

Hydroxide magnesium is Antacids , Which effectively applied for treating diseases GASTROINTESTINAL TRACT. It adsorb hydrochloric acid, reduces the proteolytic activity of gastric juice has a shielding effect. In Kardiomagnile dose contains magnesium hydroxide, which does not affect the absorption and efficacy of ASA.

Indications

Cardiomagnyl used as primary prevention of cardiovascular disease: acute heart failure, thrombosis   at presence of the of such risk factors, as the obesity . diabetes , Advanced age, hypertension, hyperlipidemia. Cardiomagnyl are taking for the prevention of re- myocardial infarction , Vascular thrombosis. After surgical interventions on vessels (percutaneous transluminal coronary angioplasty, coronary artery bypass grafting) is indicated for the prevention of cardiomagnil thromboembolism . Unstable angina .

Contraindications

The tendency to bleeding, bleeding in the brain, hypersensitivity to NSAIDs, bleeding diathesis, thrombocytopenia, a deficiency of vitamin K, bronchial asthma (caused by NSAIDs), gastrointestinal bleeding, erosive and ulcerative lesions of the gastrointestinal tract wall (exacerbation), severe renal failure, pregnancy. Cardiomagnyl not applied in paediatrics.

Be wary appoint hyperuricemia gout , Ulcerative lesions of the gastrointestinal tract (in history), bronchial asthma, renal, hepatic failure, hay fever, allergy, nasal polyposis.

Side effect

GI : Dyspepsia, heartburn , Epigastric pain, bleeding, elevated liver enzymes, esophagitis . stomatitis . colitis , Stricture, very rarely Irritable Bowel Syndrome .

CNS Insomnia, headaches, dizziness, rarely intracerebral hemorrhage, tinnitus.

Anaphylactic reactions.

Respiratory system : Rarely observed bronchospasm .

Organs of hematopoiesis: of anemia, increased bleeding, thrombocytopenia, hypoprothrombinemia, aplastic anemia, neutropenia . agranulocytosis . eosinophilia .

Mode of application

Cardiomagnyl tablets of the drug is taken orally, washed down with the required amount of water. The tablet can be pre-grind, chew, or break in half. Primary prevention of CVD on the first day take 1 ton. Cardiomagnyl 150 mg, then one pill of 75 mg daily. Prevention of thrombosis, myocardial reinfarction: 75-150 mg once a day. Prophylaxis of thromboembolic complications after surgical treatment of vascular disease (percutaneous coronary transluminal Angioplasty , Coronary artery bypass surgery), unstable angina 75 1 mg p per day.

Overdose

Manifested dizziness, hearing impairment, confusion, dyspepsia. It is necessary to wash out the stomach, take adsorbents ( Activated carbon ). Cardiomagnyl no specific antidote.

Cautions

Cardiomagnyl can lead to bronchospasm Therefore prescribed with caution in patients with a history of bronchial asthma. During and after surgery the drug can lead to bleeding. High doses of the drug have hypoglycemic action That important to consider y patients with diabetes mellitus.

Drug Interactions

Cardiomagnyl increases the effects of methotrexate, anticoagulants ( heparin ), Antiplatelet (ticlopidine), and thrombolytic agents, Digoxin , Hypoglycemic agents, sulfonylurea, valproic acid. Together with the admission of alcohol observed an additive effect. The drug reduces the effectiveness of benzbromaron   urikozuricheskih and other means. Reduces the effect of glucocorticosteroids . Kolestiramin   and antacids   reduce the absorption of cardiomagnyl.