Description overdue on 10/11/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Triampur Compositum
• Contraindications
• Side effects
• Triampur, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet contains 25 mg triamterena 12, 5 mg hydrochlorothiazide + Additional ingredients (potato starch, silicon dioxide, magnesium stearate, lactose monohydrate, povidone, sodium carboxymethyl starch).

Product form

The drug release in the form of a yellow round tablets with beveled edge, and Valium. The bottle of 50 pieces, one vial in a carton box.

Pharmacological action

Diuretic . antihypertensive .

Pharmacodynamics and pharmacokinetics

The two main active components Vehicles - triamterene   and   hydrochlorothiazide   - Moderately strong diuretics. Their pharmacodynamic and clinical features are very well understood. Substances effect mutually reinforce each other on the body, particularly in the water and electrolyte balance in the body.

Triamterene   strengthens the process of removing Sodium ion   from the body, reducing the intensity loss potassium ions   and hydrogen It refers to the group kalisberegath saluretics . The substance inhibits the process of the exchange of sodium for potassium, and hydrogen, which usually occurs in the end portions distal tubule.   However, a minor amount of sodium is derived, and the drug does not influence the process of deducing urea .

Hydrochlorothiazide   reduces the intensity of a similar process in the initial part distal tubule . Increases the excretion of potassium, chlorine, sodium and water. Also, the drug has the ability to inhibit karboangidrazu That can lead to excessive excretion bicarbonate . The primary effect of funds associated with increased excretion electrolytes And the secondary - with stimulation isolation urea .

The preparation is a combination of the active ingredients in a ratio of one to two ( hydrochlorothiazide   and triamterene ), Which significantly enhances the efficacy of the product. These opposite effects on kaliuresis   It carries out the desired effect neutralizing the potassium balance and compensation.

When administered orally, the active drug components are absorbed in the gastrointestinal tract (80%). Bioavailability thiazide   approximately 70% triamterena   - 50%. The plasma protein binds 2/3 hydrochlorothiazide And 60% triamterena . After 1 hour, begins to emerge diuretic   effect, a maximum after 4 hours and reached its peak lasts up to 12 hours, depending on the dose. Antihypertensive   the effect is more stable and can last for hours. The half-life - about 7 hours for hydrochlorothiazide and from 4 to 7 triamterena.

Thiazide not metabolized , Excreted by the kidneys virtually unchanged. Triamterene, alternatively, the reaction undergoes metabolism in the liver. Its main metabolite - 4- gidroksitriamteren -   also pharmacologically   active cleared from the blood after 3 hours in the bile or through the kidneys.

Indications Triampur Compositum

What prescribers? This tool is used:

• reducing pressure hypertension ;
• at edema Arising due to diseases of the heart, kidney or liver in cases where it is necessary to avoid the loss of potassium from the body.

It is also an indication for the use of funds is heart failure . The drug is prescribed in complex therapy cardiac glycosides To avoid loss of potassium and promote excretion of excess liquid.

Contraindications

The drug is contraindicated:

• at elevated individual Sensitivity   means a component or a group sulfonamides ;
• for serious violations in the work of the kidneys and liver;
• at anurii , Acute glomerulonephritis , Abuse   water and electrolyte balance ;
• at lactose intolerance ;
• for infants and children under the age of 14 years;
• at alcoholism ;
• with kidney stones;
• at diabetes   and gout ;
• pregnant   and nursing   women;
• deficiency folic acid .

Side effects

The drug was well researched. During clinical trials, and judging by the reviews of patients, perhaps a manifestation of the following reactions:

• hemolytic anemia . thrombocytopenia . agranulocytosis . aplastic anemia . leukopenia . neutropenia . megablasticheskaya anemia ;
• lethargy , Dry mucous membranes, headache, drowsiness . convulsions . collapse . depression . paresthesia . disorientation , Mood changes;
• ataxia , Tachycardia, arrhythmia , Changes in the electrocardiogram , Reduction Blood Pressure ;
• fainting, lightheadedness;
• violation orthostatic regulation ;
• dry eye disorders in the perception of colors; myopia ;
• pulmonary edema, pneumonia   and   respiratory distress syndrome ;
• pancreatitis , Elevated liver enzymes, cholecystitis . jaundice ;
• skin rash, hives . vasculitis . itch   and allergic reactions   to light;
• nausea, pain epigastric . constipation , Vomiting, ileus   (no symptoms when taking pills after a meal);
• increased activity of the kidneys;
• muscle convulsions , Muscle strain, hypotension   skeletal muscle;
• shock . vasculitis . anaphylactic   and anaphylactoid   reactions, exacerbation of Lupus ;
• fatigue, weakness, impotence , Reduction   libido   and sexual function, general weakness;
• development Stevens-Johnson syndrome . hepatic coma . Latent diabetes ;
• possible deterioration prediabetic   and diabetic condition . hyperkalemia . giperglikimiya . metabolic acidosis . hyponatremia , Increasing cholesterol   Blood and creatinine .

Triampur, instructions for use (method and dosage)

The dosage and duration of reception facilities should be determined by a physician on an individual basis.

If the course of treatment with long-lasting, it is impossible to sharply ceasing to drink tablets. The dose should be reduced gradually.

Tablets drink after a meal without sharing and without chewing.

Instructions for use Triampur Compositum for adults

For treatment hypertension , The initial dosage of 4 tablets per day, divided into 2 doses. Then, after some time, the dosage was reduced to 2 tablets per day (in one or two steps). If the patient further receives other means of reducing the pressure, the daily dosage is 2 pieces per day.

For treatment edema At the beginning of drinking 4-8 tablets per day, 2 doses. Supportive dosage - one tablet per day, every other day or 2 or 4 tablets per day.

As an adjuvant therapy in the treatment of Heart Failure   patients prescribed 2 tablets a day (up to 4, depending on the test results).

When kidney disease   should be corrected dose. If the concentration creatinine   in the serum is 1, 5-1, 8 mg per 100 ml or clearance   50-30 ml per minute, the daily dose should not exceed one tablet.

Overdose

In acute overdose, a strong decline Blood Pressure , up to otrostaticheskogo collapse .

Chronic administration of high doses of the drug is observed dehydration . electrolyte imbalance , Nausea, weakness, vomiting.

When the first symptoms of overdose ( weakness, confusion, heart rhythm disturbances, nausea ), Stop taking the drug. In severe cases observed alkalosis . acidosis . weakness . spasms   and overexcitement .

Specific   antidote   means none. In this regard it held gastric lavage, enterosorbents Symptomatic therapy.

It should closely monitor the condition of the patient and adjust electrolyte   and water balance   in the body, the blood sugar level, blood pH .

If there hypovolemia Shown excessive drinking, to avoid crystallization of the drug in the kidney. Recommended administration isotonic sodium hydrogencarbonate solution At hyperkalemia   - Glucose   and   insulin .

In patients with renal insufficiency, there is a need hemodialysis . In the event   bradycardia Which can not be cured, must be installed pacemaker .

Unless arterial pressure   reaches a critical minimum, arose shock Recommended administered potassium, sodium and magnesium in the form of the solution of electrolytes .

Cooperation

When combined with diuretics, phenothiazines , Vasodilators, antihypertensive agents, ethanol   and barbiturates   enhanced hypotensive effect.

Simultaneous treatment with methyldopa   It increases the likelihood of developing hemolysis .

The risk of kidney disease increases when combined with medication Triampur Compositum Indomethacin .

Diuretic effect   and the effect of reducing the pressure is increased if the drug with a crush NSAIDs . Salicylates increase the burden on the central nervous system.

Precautions should be to combine the drugs and the drug lithium, as enhanced by the load on the heart; Both funds are different cardiotoxicity .

Action curariform relaxants   enhanced by a combination drug.

ACE inhibitors   in combination with means contribute to a sharp reduction in the pressure, especially in the first days of therapy.

The absorptive capacity of the drug decreases, to use it with colestipol   or kolestriaminom .

Potassium salt, to aliysberegayuschie diuretics   and ACE inhibitors   in combination with drugs promotes development hyperkalemia , a   glyukokrotikosteroidy . chlorpropamide   and laxatives - hypokalemia .

The drug reduces the effect of drugs gout . hypoglycemic agents . norepinephrine   and adrenaline .

Triampur and Compositum beta adrnoblokatory   increase the risk of Impotence .

When combined with triampur quinidine   excretion of the latter slows down the impact of cytostatics Bone marrow is enhanced.

Terms of sale

To purchase a medicine requires a prescription.

Storage conditions

Store at a temperature not exceeding 30 degrees Celsius.

Shelf life

5 years.

Cautions

The drug should be used with caution and strictly under the supervision of a physician:

• patients concrements   kidney;
• sick diabetes ;
• deficit or suspected deficiency folic acid   in the body;
• with disorders of the liver and kidneys.

3 days prior to the trial on diabetes or learning functions kidney   or Thyroid , The drug should be discontinued.

If one of the regular reception of funds has been passed, you can not use a double dose.

During therapy, you should drink plenty of fluids.

If you wear contact lenses, it is likely that the mucous eye will need extra moisture.

To assign means children are not carried out sufficient research. In this regard, the pediatric formulation are not used.

While receiving the drug should be continuously monitored content of potassium, sodium, uric acid, chloride, creatinine, and glucose.

Caution must be exercised in the management mechanisms and transport due to the decrease rate of the reaction. The effect is especially pronounced when taking alcohol, increasing the dose, the beginning of treatment, medication replacement for analogs.

Analogs

The closest analogues: Diuretidin, Apo-triazido diazide, Triamtel, Vero Triamtezid, Triam-Caux .

During pregnancy and lactation

Medicine not appointed   at pregnancy   during breast-feeding .

Reviews Triampur Compositum

The drug is rapidly and effectively relieves edema and high blood pressure. However, he, like other diuretics, washes away from the body potassium and magnesium, so the tool should be taken with them. Some are unhappy with the fact that, if you drink the medicine before going to bed the night have to run to the toilet.

There are online and reviews of triampur for weight loss, are generally good. He even appointed doctors to treat obesity.

Price Triampur Compositum where to buy

Price triampur is about 250 rubles per 50 pieces.