Description overdue on 19.06.2012

ACE inhibitor . Active ingredient - quinapril . The mechanism of action is aimed at competitive angiotenziprevraschayuschego blocking the enzyme to reduce the speed of the transition angiotensin 1 into angiotensin 2. Akkupro increases exercise tolerance, IOC, reduces capillary wedge pressure in the pulmonary system, reduces afterload. Prolonged therapy starts the regression of myocardial hypertrophy in patients with hypertension, and injured, ischemic myocardium improves blood flow. Quinapril can increase kidney, Coronary krovoto k, reduce platelet aggregation. After a single dose of the drug begins its effective action in an hour. A full therapeutic effect is recorded over several weeks of treatment. Akkupro available in tablet form in the shell.

Indications:

Akkupro form prescribed for renovascular hypertension, renal insufficiency on the background Scleroderma At CHF after myocardial infarction in conjunction with other drugs.

Contraindications:

Akkupro not prescribe intolerance quinapril at pregnancy , Hypersensitivity to ACE inhibitors, breastfeeding. When idiopathic, hereditary forms angionervoticheskogo edema When zaboelvaniya cardiovascular, cerebrovascular disease, diabetes, severe autoimmune systemic connective tissue diseases (scleroderma, systemic lupus erythematosus ), With aortic stenosis, renal artery stenosis two, with hyperkalemia after surgical treatment for kidney transplants, the pathology of the kidney, liver, the elderly, diarrhea, vomiting Akkupro prescribed with caution, after prior consultation of experts.

Side effect:

Cardiovascular system:   myocardial infarction, Orthostatic hypotension , Ischemic type of stroke, deterioration in Raynaud's disease , Worsening of coronary heart disease, tachycardia, orthostatic hypotension. Nervous system:   fainting, depression, fatigue, headache, dizziness, mood changes, limb paresthesia , Sensory disturbances, sleep disturbances, fatigue, mental confusion. Senses Loss of taste perception, tinnitus, vestibular disorders, changes in visual perception. Digestive system:   disorders in pancreas, liver pathology system, elevation of liver enzymes, reduced appetite, diarrhea, constipation , Epigastric pain, dry mouth, hyperbilirubinemia.   Bodies of blood:   pancytopenia, neutropenia , Leukopenia, anemia, agranulocytosis. Respiratory system:   sinusitis, bronchial spasm, bronchitis, cough, rhinitis. Urogenital:   reduced potency, urinary retention, proteniuriya, hypercreatininemia , Increased levels of urea, urinary retention. Perhaps the development of allergic reactions, glossitis, pruritus, erythema multiforme ekssudatichnoy, hyponatremia, hyperkalemia , Myalgia, hyperthermia, exfoliative dermatitis, photosensitivity, arthralgia, alopecia.

Overdose:

It manifests a pronounced fall in blood pressure, disturbance visual perception , Weakness, dizziness. Treatment posindromnoe.

Mode of application:

Akkupro taken orally. The initial dose for hypertension is 10 mg (1 or 2 admission). With the ineffectiveness of the dose is gradually increased to 20 mg for three weeks. The average therapeutic dose of 10-20 mg a day, a day is not more than 80 mg. Elderly individuals with renal pathology system to reduce the dose of 5 mg per day.

Special instructions:

Patients with reduced BCC, diarrhea, vomiting, limiting your salt intake, diuretics Akkupro prescribed with caution because of the risk of a sharp drop in blood pressure .  With the development of transient hypotension drug is not canceled, the dosage is reduced, the pressure is stabilized .  With a sharp drop in blood pressure patient impart horizontal, saline-it treated to increase the bcc .  2-3 days prior to initiation of therapy should be repealed diuretic drugs, except in cases with malignant hypertension .  In decompensated heart failure, malignant hypertension during therapy quinapril begin in hospital .  It takes control of the level of white blood cells, hemoglobin, potassium, urea, creatinine, liver enzymes .  It is unacceptable the simultaneous use of dialysis membrane AN69 because of the risk of anaphylactoid reactions .  Newborns whose mothers took during treatment quinapril, carefully watching for timely diagnosis of oliguria, hypotension, hyperkalemia . With the development of oliguria requires renal perfusion by infusion of vasoconstrictor drugs, appropriate fluids, as well as maintenance of blood pressure. In infants, newborns develop oliguria, neurological symptoms occur in the fall of blood pressure, reduction of cerebral, renal blood flow. Akkupro affect the control of vehicles. Patients should be careful when doing physical work in hot weather because of the risk of dehydration and hypotension. Prior to surgery, the anesthesiologist and the surgeon necessarily warn of medication Akkupro.

Drug Interactions:

Akkupr enhances effect of ethanol. When you receive procainamide, immunosuppressants , Cytostatics, allopurinol   the risk leukopenia . Quinapril enhances hypoglycemic effect of insulin, sulfonylurea and its derivatives. Narcotic analgesics, diuretics, antihypertensives, drugs for general anesthesia increase the hypotensive effect of Akkupro. Upon receipt of salt, there is a weakening effect of NSAIDs. Potassium-sparing diuretics   (triamterene, spironalokton, amiloride), potassium supplements cause hyperkalemia. While taking estrogen registered weaken hypotensive effects due to fluid retention in the body. Risk agranilotsitoza, neutropenia   increases when taking medicines which depress the bone marrow.