Description overdue on 29.03.2012

Antiarrhythmic drugs . The active component acts hydrobromide lappaconitine . The main component is the alkaloid beloustogo aconite. The principle of operation is aimed at blocking the "fast" sodium channels in membranes of cardiomyocytes. Allapinin slows intraventricular conduction , Atrioventricular conduction, shortens functional, effective refractory period of atria, Purkinje fibers, bundle branch block , AV-node. The drug has no effect on the contractility of the myocardium, blood pressure and pulse. The drug has no negative inotropic and hypotensive effects, does not inhibit automatism sinus . VFS has sedative, Valium, m-anticholinergic, koronarorasshiryayuschee, moderate antispasmodic effects. The drug is available as a solution in a tablet form.

Indications:

VFS is prescribed for tachycardia   (Ventricular, paroxysmal, supraventricular) at ekstrasistoliyah   (ventricular, supraventricular forms), with atrial flutter , Paroxysm flicker, myocardial infarction with heart rhythm disorder, the syndrome of premature ventricular excitation.

Contraindications:

VFS is not prescribed for   intraventricular conduction blockade , Intolerance lappaconitine hydrobromide, SA-blockade of the second degree, severe course of hypertension, breastfeeding, cardiogenic shock, severe kidney and liver disease, pregnancy. When angle-closure glaucoma, bradycardia, compensated form of chronic heart failure, legs blockade branch block, conduction disorders of Purkinje fibers, lack of renal and hepatic systems, with cardiomegaly , Carrying out pacing in pediatric patients administered with caution.

Side effect:

VFS can cause sinus tachycardia , Arrhythmogenic effects, headache, dizziness, expansion of the complex QRS, lengthening of PQ interval on an electrocardiogram, slowing intraventricular conduction, ataxia, diplopia, allergic reactions, facial flushing.

Mode of application:

VFS appoint vnutrimychshechno, intravenously, orally. Tablets: three times a day to 25 mg half an hour before a meal. The tablet is desirable to pre-grind. With the ineffectiveness of the dose was increased to 100 mg a day for 4 doses. The course of treatment - a few months. The highest daily dose - 300 mg, 150 mg single. Allapinin intravenously injected slowly 5 minutes: the calculation scheme 0, 3-0, 4 mg / kg. In severe renal disease reduce the dosage.

Special instructions:

With the development of double vision, dizziness, headaches Allapinin cancel or reduce the dosage. Long-term treatment with low doses beta-blockers   can cause sinus tachycardia. Re-drug can be administered parenterally in only six hours. When pregnancy (first trimester) appointment is valid only on the "vital" indications. Patients with decompensated form of HF and AV block of first degree drug is prescribed only in a hospital under the supervision of the ECG, a doctor's supervision.

Drug Interactions:

VFS enhances the effect of muscle relaxants (non-depolarizing). Anti-arrhythmic drugs other classes may cause arrhythmogenic effects. Reducing the effectiveness of notes, while appointment inducers of microsomal enzymes   in the hepatic system. The risk of toxic effects increases with reception inhibitors of microsomal oxidation .