Description overdue on 13.01.2012

Beta-blocker . The main active-active substance acts propranolol   Inderal is a blocker with indiscriminate effect, reduces sympathetic influence on beta-adrenergic receptors of the heart, reduces the frequency and force of heart contractions, reduces myocardial contractility, adjusts downward the value of cardiac output, blocks the positive inotropic and chronotropic effects of catecholamines, reduces the heart's need for oxygen, reduces arterial pressure .  Increases tone bronchi through blockade of beta2-adrenergic receptors .  Inderal increases the contractility of the uterus, reduces the risk of bleeding during childbirth, postpartum and postoperative periods .  When administered drug is rapidly absorbed and excreted .  The maximum peak content of active substance in the blood plasma after 1 registers -1 . 5:00 .  The drug penetrates the fetoplacental barrier .  Anaprilin available in tablet form, in the form of capsules, eye drops, solution for injection .

Indications:

Inderal is prescribed for hypertension . sinus tachycardia . angina   voltage, supraventricular tachycardia, unstable angina, atrial fibrillation (tachysystolic form), for the prevention of migraine attacks, sympathoadrenal crises, NDCs. When hypertension drug is effective in the early stages of the disease, and therefore used more often in young people (under 40 years). Lowering systolic pressure is accompanied by a decrease in heart rate, decrease in volume of cardiac output and stroke volume. When coronary heart disease taking the drug reduces the number of attacks   angina It increases resistance to physical stress. Especially effective with concomitant hypertension, arrhythmia.

Contraindications:

Inderal is not prescribed for hypotension , Hypersensitive to the components, congestive heart failure, atrioventricular block, sinus bradycardia . sinoatrial blockade , Diabetes mellitus, acute myocardial infarction, asthma, obliterating vascular diseases, metabolic acidosis , Tendency to bronchospasm, vasomotor rhinitis , Pregnancy, breastfeeding.

Mode of application:

Initial dosage in hypertension - 40 mg twice a day. The day not more than 320 mg. When cardiac arrhythmias, angina pectoris: three times a day to 20 mg with gradual increase in dose to 120 mg per reception 2-3. With tireotoksicheskom Stroke , Paroxysmal arrhythmias prescribe intravenous drug Inderal dose of 1 mg, slowly, after 2 minutes repeat injection. In the pathology of renal dose adjustment is required.

Side effect:

There bradycardia , Atrioventricular block, bronhiolospazm, development Raynaud's syndrome , Heart failure, vomiting, muscular weakness , Epigastric pain, vomiting, diarrhea . itching . depression . hypoglycemia   in patients with insulin-dependent and increase blood glucose levels in patients with a history diabetes   insulin dependent type, impaired vision, reduced potency.

Special instructions:

Contraindications to the drug Inderal together with tranquilizers and neuroleptics . With long-term treatment of drug Inderal recommended while taking cardiac glycosides . Cancel the drug should be done gradually in order to prevent the development of acute myocardial ischemia   or bronholospazma. When arrhythmias beta blocker Inderal contributes to the normalization of sinus rhythm, atrial fibrillation transition from tahisitolicheskoy in bradisistolicheskuyu and reducing subjective outages heart. Perhaps the oppression of the reaction and attention that should be considered when prescribing drivers, operators and persons of similar professions.

Drug Interactions:

Anaprilin reinforce negative impact diltiazem   and verpamila   on the myocardium, slows excretion of lidocaine prolongs duration nonpolarizable muscle relaxants . The antihypertensive effect is weakened when taken with glucocorticosteroids , Estrogen, NSAIDs. The hypotensive effect is enhanced by the use of nitrates. Antacids and heparin reduces the concentration of drug in the blood, phenothiazines   and cimetidine   - Increase. Not allowed simultaneous application MAO inhibitors . Inderal increases the concentration theophylline plasma It slows down its metabolism.