Description overdue on 01/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Contraindications
• Side effects
• Instructions for use Halidorum (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Every   It contains 100 mg of fumarate bentsiklana polyvinyl acetate . magnesium stearate Carbomer 934 P, sodium carboxymethyl starch  

The preparation Halidorum in solution   for intramuscular and intravenous administration contains 25 mg per 1 ml solution of 50 mg fumarate bentsiklana   per capsule. The solution contains excipients and 8 mg sodium chloride   (in dosage forms ) And 2 ml of water for injection.

Product form

The drug comes in two forms:

• White or grayish-white pills , Round shape, flat, they have a chamfer engraving " HALIDOR "On one side of the tablet, there is faint characteristic odor. Tablets of 50 pieces are placed in vials made from amber glass. Each bottle is placed in a cardboard box.
• Injections Halidorum   - Solution for intravenous and intramuscular administration has the form of transparent, colorless, odorless liquid. The solution is sold in vials (2 ml volume each). 5 vials are placed in blisters, and blisters to 2 pieces placed in cardboard boxes or 10 cartons.

Pharmacological action

Halidorum is myotropic antispasmodics It is expressed by vazodilatirtee   (vasodilator) effects.

heart rate , To provide small tranquilizing effect .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Bentsiklan   It has a vasodilatory effect is mainly due to its ability to block Calcium channels And to some extent - the property to create blockade of sympathetic ganglia . Also bentsiklan   dose-dependent inhibition can cause Na + / K + -dependent ATPase , Reducing the aggregation of some blood cells ( Platelet and erythrocyte ) And increase the elasticity erythrocyte . These effects are primarily observed in coronary arteries , Peripheral vascular and cerebrovascular disease.

Except as described above, bentsiklan   It has antispasmodic effect on visceral musculature   (muscles of the urinary tract, the gastrointestinal tract, the respiratory system).

Pharmacokinetics

After receiving inside Halidorum bentsiklan   It absorbed from the gastrointestinal tract rapidly and almost completely. The maximum concentration   in human plasma, accepting the drug is usually reached after 3 hours (but this period can have a duration of from 2 to 8 hours) after ingestion. first pass "Through the liver, resulting in   bioavailability   medication ingestion is equal to 25-35%.

In the circulating blood bentsiklan   distributed approximately in such proportions:

• 30% - associated with red blood cells;
• 10% - with platelets;
• 20% .- free fraction.

Metabolism   During the metabolic processes occurs dealkylation That ultimately gives demethylated derivative ether bond benzoic acid Which is subsequently converted to hippuric acid .

Half life   It lasts from 6 to 10 hours. Displayed medicament mainly in the urine as inactive metabolites but may be output in unchanged form (not more than 2-3%). conjugate Formed with glucuronic acid ).

Indications Halidorum

Indications for use Halidorum enough.

• peripheral vascular disease - at Raynaud's disease And other diseases, which often develops acrocyanosis   and vasospasm, chronic   obliterating diseases of arteries ;
• cerebral vascular diseases: use in the treatment, both in the acute and the chronic form Cerebral ischemia ;
• occurrence of spasms of internal organs;
• gastrointestinal diseases - gastroenteritis   different etiology (particularly infectious), infectious and inflammatory colitis , Functional bowel disease, tenesmus Aftercare flatulence . cholecystitis . cholelithiasis Cholecystectomy , When dysmotility sphincter of Oddi dyskinesia . gastric ulcer and duodenal ulcer   (used as part of combination therapy ongoing);
• urological syndromes: cramps and tenesmus Bladder , Concomitant therapy urolithiasis   (administered in combination with painkillers at );
• preparation for instrumental methods used in urology.

Contraindications

Contraindications to the use of medications include:

• heavy respiratory failure ;
• renal failure   (with severe disease);
• heavy liver failure ;
• decompensated heart failure ;
• sharp myocardial infarction ;
• AV-block ;
• paroxysmal supraventricular   or acute ventricular tachycardia ;
• epilepsy   and other forms of spazmofilii ;
• recently transferred hemorrhagic stroke ;
• traumatic brain injury (their presence in the last year);
• pregnancy;
• breastfeeding;
• age 18 years;

Side effects

On the part of some systems of the human body may be a manifestation of side effects of the drug:

• Digestive system : May cause dry mouth, abdominal pain, feeling of fullness, nausea . vomiting . loss of appetite . diarrhea In serum may increase the activity of hepatic transaminases .
• Central nervous system : There is a probability of occurrence of anxiety, dizziness, headache, abnormal gait, tremor , Sleep disorders, insomnia, memory disorders; rarely observed transient confused state of mind Appearance   epileptiform seizures Hallucinations; in rare cases, symptoms of focal lesions of the central nervous system.
• Cardiovascular system atrial and ventricular tachyarrhythmias   (especially increases its probability Halidorum when co-administered with other drugs proaritmogennoe).
• In addition to the above side effects, you may experience general malaise, weight gain, development of leukopenia, allergic reactions; occasionally seen thrombophlebitis   when administered intravenously.

When vascular diseases

Inside medicine taking 100 mg three times a day for 2 or 3 months. The maximum dose which can be taken in per day - 400 mg (tablet). Between courses of the drug to do an interval of 2 to 3 months.

In an intravenous infusion take 200 mg (per day). The daily dose is divided into 2 administration. Before you spend infusion, 100 mg (contained in a 4 ml solution for intravenous and intramuscular administration) of the drug should be diluted in 100-200 ml of isotonic sodium chloride solution, and then enter intravenously over 1 hour, this should be done 2 times

Spasm of the internal organs

Inside designate 100-200 mg for one time, but not more than 400 mg per day.

In the case of maintenance therapy Halidorum administered 100 mg three times a day for 3 or 4 weeks, and then 100 mg 2 times a day. Duration of treatment is determined individually for each person and depends on when the symptoms disappear. Typically, this period lasts for more than 1-2 months.

When used in acute cases, the drug is administered intravenously respectively instructions for use injections Halidorum - slowly in an amount of 100-200 mg (4-8 ml of this solution) or deep intramuscularly in an amount of 50 mg (2 mL). Before intravenous dose desired solution is diluted with isotonic sodium chloride solution to 10-20 ml. The length of treatment is 3 weeks 2-yl, then, if necessary, the patient is transferred to the reception Halidorum inside.

Overdose

If overdose is increased heart rate , Decreases arterial pressure May develop collapse , Renal failure, urinary incontinence occur, characterized by drowsiness, restlessness, in severe cases may cause epileptiform seizures. If a large overdose can occur tonic and clonic convulsions.

In case of overdose symptomatic therapy. If you have made a large number of tablets you need to gastric lavage. In the case of seizures recommend the use of benzodiazepines . Data on whether it is possible to deduce   by dialysis, no.

Cooperation

The simultaneous use of some drugs Halidorum can lead to side effects. Therefore, we must be cautious in combination with such drugs:

• Means for anesthesia and sedatives   - Such a combination increases the inhibitory effect Halidorum the central nervous system.
• tachycardia , Atrial or ventricular .
• Drugs that reduce the level of potassium in the blood (such drugs include diuretics   and ) And quinidine - can occur summation proaritmogennoe effects.
• Digitalis preparations   - Increase the risk of arrhythmia in the case of an overdose cardiac glycosides .
• Beta-blockers   - There is a need to adjust the dose of beta-blockers, as these drugs have the opposite chronotropic   effects (beta-blockers have a negative effect, while bentsiklana   - Positive).
• Calcium channel blockers   and other antihypertensive drugs - may increase the effect.
• Drugs cause side effects in the form of spazmofilii   - There is a probability summation of these effects.
• Acetylsalicylic acid   - Can enhance the inhibition platelet aggregation .

Terms of sale

Storage conditions

The drug should be stored out of the reach of children, in temperature conditions of 15 ° C to 25 ° C.

Shelf life

Tablets are fit to 5 years. The solution for injection is fit 3 years.

Cautions

At the beginning of the course of the drug is necessary to be very careful when driving cars and other vehicles, as well as any other activities that could be potentially dangerous.

Analogs Halidorum

Halidorum analogs are drugs such as Bentsiklan, Bentsiklana fumarate, Vinoksin CF Dibazol, Dibazol-Darnitsa, Duzofarm, Papazol, Enelbin 100 Retard .

Babies

Do not appoint.

During pregnancy and lactation

Preclinical studies have failed to reveal any embryotoxic or teratogenic effects, but at the same time, adequate and well-controlled clinical studies on the use of medications during pregnancy and Halidorum during lactation have not been conducted. Therefore, the drug in the hours I trimester of pregnancy is not desirable.

If necessary, the administration of the drug during lactation is necessary to solve the question of the appropriateness of termination of breastfeeding during treatment.

Reviews Halidorum

Doctors about Halidorum agree that the drug is quite strong and it is very important not to forget in its application to be careful, especially the elderly and people prone to allergies. Reviews on the forums also confirm the high probability of side effects in people prone to this.

Price Halidorum where to buy

Price   (50 pieces) - about 300-350 rubles.

Cost ampoules   (10 pieces) - from 400 to 450 rubles.