Description overdue on 01.04.2012

Antiarrhythmics Inhibitor repolarization. The main ingredient - amiodarone . Has vasodilatig, antianginal, hypotensive, alpha-adrenoceptor blocking beta-adrenoceptor blocking action. Under the action of the drug reduces the need for oxygen in the cardiac muscle, which explains   antianginal effect . Kordaron inhibits operation of alpha, beta-adrenoceptor cardiovascular system without blocking them. Amiodarone reduces sensitivity sympathetic nervous system hyperstimulation, lowers the tone of the coronary arteries, improves blood flow, uryazhaetsya pulse, increases the energy reserves of the myocardium, reduces blood pressure. Antiarrhythmic effect is the influence on the course of electrophysiological processes in the myocardium, lengthening the action potential myocardiocytes, increasing refractory, effective period fibrillation, bundle branch block, AV node, the ventricles. bradycardia . The structure of the main component of the drug similar to the thyroid hormone. Kordaron available in tablet form, as a solution.

Indications:

Kordaron prescribed for paroxysmal arrhythmias (treatment and prevention) ventricular fibrillation , Fatal ventricular arrhythmia, supraventricular arrhythmia, atrial flutter, paroxysm of atrial . angina , Ventricular arrhythmia in patients with Chagas disease myocarditis Arrhythmia in coronary insufficiency, .

Contraindications:

Kordaron not prescribed for sinus bradycardia , Hypersensitive to iodine, amiodarone, in cardiogenic shock , Collapse, hypokalemia, hypothyroidism , Hypotension, breastfeeding, interstitial lung disease, pregnancy, taking MAO inhibitors, hypokalemia, 2-3 degree atrioventricular block. The elderly, with liver disease, heart failure, in patients under 18 years, the pathology of the liver system used with caution.

Side effect:

Nervous system:   sleep disorders, memory disorders, peripheral neuropathy , Paresthesia, auditory hallucinations, fatigue, depression, dizziness, weakness, headache, optic neuritis, intracranial hypertension, ataxia, extrapyramidal symptoms . Senses:   mikrootsloyka retinal deposition of lipofuscin in the corneal epithelium, uveitis. Cardiovascular system: drop in blood pressure, tachycardia, heart failure progression, atriventrikulyarnaya block, sinus bradycardia. Metabolism: hyperthyroidism, hypothyroidism, increased levels of T4. Respiratory system : apnea . bronchospasm , Pleural effusion, pulmonary fibrosis, alveolitis, anterstitsialnaya pneumonia, shortness of breath, cough. Digestive system: cirrhosis of the liver , Jaundice, cholestasis, chronic hepatitis, increased liver enzymes, loss of taste perception dullness, loss of appetite, vomiting, nausea. Prolonged use causes aplastic anemia Hemolytic anemia, thrombocytopenia, allergic reactions, dermatitis. For parenteral administration developed phlebitis. Cordarone can cause alopecia, reduced potency, myopathy, vasculitis, epididymitis, photosensitivity, pigmentation of skin, increased sweating.

Overdose:

It is characterized by a fall in blood pressure, atriventrikulyarnoy blockade, bradycardia. Required assignment kolestiramina , Gastric lavage, install a pacemaker. Hemodialysis is recognized as ineffective.

Mode of application:

Kordaron administered intravenously according to a 5 mg / kg for the relief of severe arrhythmias, in patients with CHF is calculated by the scheme 2, 5 mg / kg. Infusion was carried out for 10-20 minutes. Cordarone Tablets take before eating: 0, 6-0, 8 grams per reception 2-3; doizrovku reduced to 5-15 days 0, 3-0, 4 grams a day, then transferred to maintenance therapy 0 2 grams per day for 1-2 reception. To prevent accumulation of drug taking 5 days and then make a break for 2 days.

Special instructions:

On the eve of the appointment of antiarrhythmic therapy is carried out survey of the hepatic system, evaluate the work of the thyroid gland, conduct X-ray examination of the pulmonary system, determine the level of electrolytes in plasma. During treatment, be sure to carry out control over the level of liver enzymes, EKG. Respiratory function examined every six months, X-ray examination of the lungs is carried out once a year, the level of thyroid hormones is determined every 6 months. In the absence of clinical thyroid dysfunction antiarrhythmic treatment continues. It is recommended to use a special sunscreen, avoid direct sunlight for the prevention of photosensitivity . Requires periodic surveillance by an ophthalmologist for the diagnosis of deposits in the cornea. Cancel the drug can cause a recurrence of arrhythmias. Parenteral drug Cordarone is possible only in a hospital under the control of blood pressure, pulse, electrocardiogram. Appointment of breastfeeding and pregnancy is possible only in cases that threaten a woman's life. Field treatment discontinuation pharmacodynamic effect persists for 10-30 days. Kordaron in its composition contains iodine, which can cause tests to determine lozhnoplozhitelnye radioiodine   in the thyroid gland. When surgical team should be informed about the use of the drug because of the possibility of Distress Syndrome acute form.

Drug Interactions:

Cordarone causes raising procainamide, phenytoin, quinidine, digoxin, cyclosporin, flecainide plasma. The drug causes increased effects anticoagulants   (acenocoumarol and warfarin). When assigning warfarin its dosage is reduced to 66% when assigning acenocoumarol - 50%, prothrombin time required monitoring. "Loop" diuretics , Astemizole, tricyclic antidepressants, phenothiazines, terfenadine, thiazides, sotalol, glucocorticosteroids, laxatives, pentamidine, tetracosactide, antiarrhythmic agents of the first class, amphotericin B may sprovotsirovat arrhythmogenic effect. Cardiac glycosides . verapamil , Beta-blockers increase the likelihood of depression atriventrikulyarnoy conductivity of bradycardia. Medicines that cause photosensitivity, can provoke additive photosensitizing effects. Hypotension, bradycardia, conduction abnormalities may develop during oxygen therapy, during general anesthesia with the use of drugs for inhalation anesthesia. Kordaron able to inhibit the absorption of pertehnetta sodium . sodium iodide   thyroid gland. With simultaneous use of drugs lithium increases the risk of developing hypothyroidism. Cimetidine increases the half-life of the main component, and colestyramine reduces its absorption into the blood plasma.