Description overdue on 24.02.2012

Beta-agonists . The active substance is Phenylephrine . The drug is not   catecholamine No effect on beta-adrenergic receptors of the heart, the aromatic ring contains only one hydroxyl group. Mezaton addition to raising blood pressure, simultaneously leads to the development of reflex bradycardia It narrows the lumen of arterioles. Compared with epinephrine norefrinom smoothly increases blood pressure, the effect lasts longer. Mezaton is produced in the form of nasal drops, solution.

Indications:

Mezaton parenterally administered in the state of shock, hypotension , Vascular insufficiency. When conducting a local anesthetic phenylephrine is used as a vasoconstrictor. Nasal drops prescribed for allergic rhinitis,   vasomotor rhinitis .

Contraindications:

Mezaton not prescribed for pheochromocytoma , Hypersensitive to phenylephrine, ventricular fibrillation . When hypercapnia, atrial fibrillation, hypoxia, metabolic acidosis , Hypertension, angle-closure glaucoma, severe aortic stenosis, hypovolemia, tachyarrhythmias, acute myocardial infarction, ventricular arrhythmias, atherosclerosis, Buerger's disease, pregnancy, diabetic endarteritis, thyrotoxicosis, breastfeeding, pediatric administered with caution.

Side effect:

Bradycardia, headache, vomiting, nausea, unstable blood pressure, tachycardia, palpitations, ventricular arrhythmia, allergy, restlessness, irritability.

Overdose:

Excessive increase in blood pressure, ventricular premature beats , A feeling of heaviness in the limbs, head, short paroxysms of ventricular tachycardia. It should be an emergency intravenous administration of phentolamine (an alpha-blocker, has a short action), rhythm disturbances introduced beta adrenobloktaory.

Mode of application:

Mezaton slowly injected intravenously. During collapse administered 1% solution (0, 1 to 0, 5 ml) previously diluted in a solution of sodium chloride, dextrose. To reduce inflammatory reactions vasoconstriction mucosal or lubricated instilled 0 125% solution.

Special instructions:

It requires monitoring of blood pressure, electrocardiogram. In patients with arterial hypertension medication collapse   necessary to maintain systolic blood pressure above the normal 30 mm Hg. Art. Before the treatment of states of shock, shall adjust hypercapnia, acidosis, hypovolemia, hypoxia. With age, decreasing the number of adrenergic receptors, which are sensitive to phenylephrine.

Drug Interactions:

Mezaton reduce the hypotensive effect of diuretics, antihypertensives. Oxytocin , MAO inhibitors, ergot alkaloids, methylphenidate, tricyclic antidepressants increase the arrhythmogenic phenylephrine increase pressor effect. Inhalation anesthetics increase the risk of severe arrhythmia (ventricular, atrial form). Mezaton reduced antianginal effect of nitrates. Oxytocin, metilergometrin, ergotamine increases the severity of vasoconstriction. Thyroid hormones are mutually enhance the effectiveness of phenylephrine, which increases the risk of developing coronary heart disease (in severe coronary atherosclerosis). Enflurane, chloroform, methoxyflurane, halothane, isoflurane, and other inhalation anesthetics enhance the sensitivity of myocardial cells to the action of sympathomimetic.