Description overdue on 10/26/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Renitek
• Contraindications
• Side effects
• Instructions for use Renitec (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The active ingredient of the drug - enalapril maleate .

Additional components: corn starch . lactose monohydrate . pre-gelatinized starch . sodium bicarbonate . magnesium stearate . In addition, the drug may be iron oxide red   (tablets of 10 and 20 mg) and yellow iron oxide   (20 mg tablet).

Product form

The pharmacy network can be found on the 7 tablet pieces contained in the contour packaging. One carton box Renitec has a 2 or 4-outline package. In addition, the drug is sold in bottles of dark glass, which contains just 100 tablets.

Pharmacological action

This tool is ACE inhibitor . It has hypotensive , and vasodilator   action.

Pharmacodynamics and pharmacokinetics

The drug is antihypertensive   agent. The active ingredient of the drug is converted in the body enalaprilat Which oppresses ACE   ( angiotensin-converting enzyme ). This prevents transformation Angiotensin I   at Angiotensin II   and synthesis of aldosterone And also increases the activity Renin   plasma. In addition, the drug increases prostaglandin E   and nitric oxide reduces the excretion of potassium ions to a small extent, accelerate the excretion of sodium ions, and also reduces the level of circulating catecholamines .

The active substance Renitec helps reduce blood pressure. People with essential hypertension   it also prevents the common peripheral vascular resistance   and promotes cardiac output . In patients with renal problems and proteinuria   a decline albuminuria , Urinary excretion of IgG and total protein   urine. And in the case Heart Failure   reduced rate ventricular arrhythmias .

Enalaprilate   It helps in regression of left ventricular hypertrophy with maintaining systolic function .

After applying the tablets into action develops over 1-4 hours, they remain effective during the day. The drug is rapidly absorbed, and then split up enalaprilate . Mealtime no effect on their operation.

The maximum decrease Blood Pressure   It is observed after about 5 hours after drug application.

Indications Renitek

Indications Renitek following:

• heart failure ;
• Essential   and renovascular hypertension ;
• asymptomatic left ventricular malfunction in order to prevent the development of severe Heart Failure ;
• disruption of the left ventricle when the need for prevention coronary ischemia .

From what pomogaut tablets in each case, only the doctor knows, so it is not recommended to take the tool without setting a specialist.

Indications Renitek also provide for the appointment of his people with unstable angina   to reduce the frequency of hospitalizations and prevention of myocardial infarction .

Contraindications

This tool is contraindicated in angioedema   at history   for receiving ACE inhibitors , and hypersensitivity   to its components.

In addition, the drug can not be taken at hereditary   or idiopathic angioedema . lactase deficiency . galactosemia   and glucose-galactose malabsorption . Contraindicated for the appointment of people on hemodialysis   with high permeability membranes, pregnant women, lactating women, children under 1 month, children with a level glomerular filtration rate   less than 30 ml / min / 1, 73 sq. m.

With care facility applies to operations, with impaired renal function . Heart Failure . cerebrovascular disorders , Therapy diuretics . coronary heart disease . hemodialysis And when aortic stenosis . bilateral renal artery stenosis , Water and electrolyte imbalance, or   artery stenosis of a solitary kidney .

Side effects

In applying the drug may be the following side effects:

• CCC - hypotension , Fainting, orthostatic hypotension ;
• digestive system - diarrhea Nausea;
• allergy - skin rash;
• skin - hyperemia   skin, itching . alopecia ;
• nervous system - headache . dizziness . asthenia , Fatigue;
• respiratory system - a cough;
• laboratory parameters - hyperkalemia , Reducing the concentration Hemoglobin   and hematocrit . hyponatremia ;
• Other - increased sweating, impotence Changes in taste, seizures, glossitis , noise in ears.

In rare cases, also noted:

• digestive system - increase in liver transaminases . hepatic failure . jaundice . ileus , Vomiting, constipation . stomatitis . pancreatitis . hepatitis , Pain in the abdomen, dyspepsia . anorexia , Increasing bilirubin   plasma;
• CCC - acute myocardial infarction . stroke , Heart rhythm disorders, pain in the chest, angina , Palpitations;
• urinary system - problems with the kidneys, oliguria , Increased creatinine . renal failure , Increase content urea ;
• nervous system - depression , Sleep problems, tinnitus, confusion, paresthesia , Blurred vision;
• respiratory system - pulmonary infiltrates , Shortness of breath, pharyngitis . bronchospasm . rhinorrhea , Hoarseness;
• allergy - Stevens-Johnson syndrome . angioedema   limbs, face, tongue, lips, glottis, larynx; erythema multiforme . pemphigus . exfoliative dermatitis . hives . Lyell's syndrome And the development of a complex of symptoms including positive test Antinuclear antibodies . vasculitis . fever . arthralgia   or arthritis , Increasing ESR . leukocytosis . serositis . myalgia   or myositis . eosinophilia .

Typically, side-effects are rare. In most cases, they go with the times and do not require discontinuation of treatment.

Instructions for use Renitec (method and dosage)

For patients who are appointed Renitek, instruction on the application reports that the drug is intended for oral   use. Means should be swallowed whole without crushing or chewing, it is recommended to drink it with water. Tablets are divided only in the case of need for accurate dosing. In order to achieve maximum therapeutic effect and continuous monitoring of blood pressure indicators Instructions for use Renitek recommends to use them in the same time of the day. The duration of therapy and determine the exact dosage expert individually.

Adult patients are usually given 10-20 mg / day. If necessary, the dosage can be increased. The maximum dose of the drug should not be more than 40 mg. Maintenance dose - 20 mg.

With renovascular hypertension Usually need to take two adults, 5-5 mg / day. If necessary, the dosage is increased.

The recommended maintenance dose of 10-20 mg is appointed.

If the patient was taking before diuretics , The initial dosage should be no more than 5 mg. Gradually, it can optionally be raised. Be sure to take into account that diuretics   you need to stop taking is not less than 2-3 days before you start taking the tablets Renitec.

The initial dosage in case of violation of the kidneys is 5-10 mg / day.

With creatinine clearance :

• from 80 to 30 ml / min - 5.10 mg / day;
• from 30 to 10 ml / min - 2 5-5 mg / day;
• to 10 ml / min - 2 5 mg / day.

Adult patients with Heart Failure   and asymptomatic left ventricular disruption to give 2, 5 mg / day. This medicine may be used as part of combination therapy Heart Failure . If it is well tolerated symptomatic or after hypotension , The initial dosage can be gradually improved. Thus it is necessary to constantly monitor blood pressure, kidney function, and the concentration of potassium in the blood plasma.

The recommended daily dose of maintenance - 20 mg. It is taken once or divided into twice.

For children from 1 month to 16 years are 0, 08 mg / kg once a day. If necessary, the dose may eventually rise.

Overdose

At doses in excess of the expression appears hypotension Which is noticeable after six hours after ingestion, and coincides with blockade of the renin-angiotensin   system. It may also occur stupor.

As a therapy to be administered isotonic   solution intravenously. If an overdose has occurred recently, it is recommended gastric lavage. The active substance can also be removed from the systemic circulation by Hemodialysis .

Cooperation

Antihypertensive   and diuretic   drugs interacting with Renitec lead to increased hypotensive   effect. And when combined with potassium-sparing diuretics   and drugs that contain potassium, increases the likelihood of hyperkalemia .

Together with lithium Renitek reduce excretion of lithium and increases their toxicity. In collaboration with non-narcotic analgesics   It increases the likelihood of nephrotoxic   effect.

Terms of sale

The drug is sold in the pharmacy network with a prescription.

Storage conditions

The drug should be kept in a dry place, in which no light penetrates. Temperature - 30 ° C.

Shelf life

Do not store the medication for longer than 30 months.

Analogs Renitek

Analogs Renitek in the pharmacy network, you can find the following:

• Berlipril ;
• Sandoz Aisne ;
• Enalapril ;
• Enalapril-Astrafarm ;
• Enalapril-Darnitsa ;
• Enalapril-Health ;
• Enalozid Mono ;
• Enap ;
• Co-Renitec .

Difference and Co-Renitec Renitec

The key difference, and Renitek Co-Renitec   in the composition. Besides enalapril second drug comprises also hydrochlorothiazide . Thus, it possesses antihypertensive And diuretic   action.

Reviews Renitek

Reviews of medicine Renitec can be found on the Internet frequently. He has a lot of evidence. Exactly how to take this tool and what should be the duration of therapy in each case he knows a doctor. Thus, it can not be taken without the prescription of a specialist. Review Renitek indicate that some patients take it for a long enough time and efficiency point throughout therapy.

Price Renitek where to buy

In the tool may be different value depending on the form of release. Thus, the price Renitec tablets 10 mg - about 80 rubles. The cost of the tablets of 20 mg (in a cardboard bundle 14 pieces) - an average of 140 rubles. And the price of Renitec tablets 5 mg - 70 rubles.