Description overdue on 08/24/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Valsacor
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Valsacor tablets contain as active substance valsartan And auxiliary components such as lactose monohydrate, povidone, colloidal and anhydrous silica, MCC, croscarmellose sodium, magnesium stearate.

Film-coating formulation includes components such as a dye iron oxide red, macrogol 4000, titanium dioxide, Valium. The 160 mg tablets also present dye iron oxide yellow.

Valsacor H 80 . H 160   and ND160   It contains active ingredients such as   valsartan   and hydrochlorothiazide , Plus the following additional components: colloidal and anhydrous silica, MCC, povidone, magnesium stearate, croscarmellose sodium, lactose monohydrate.

As part of the film coating of tablets is available titanium dioxide . dye yellow iron oxide . Valium . iron oxide red dye, macrogol 4000 . .

Product form

The medicine is available in tablets, which are coated (film).

Pharmacological action

Valsacor   It has antihypertensive effect.

Valsacor N80 . N160   and ND160   They are hypertensive agents.

Pharmacodynamics and pharmacokinetics

Valsacor influences angiotensin II receptors . The active ingredient of the drug is AT1 receptor antagonist Because it stimulated AT2 receptors . The facility has antihypertensive effect It leads to normal systolic blood pressure, reduces peripheral vascular resistance and cardiac output improves.

This medicine has no effect on heart rate and normalizes the state of health of people with Heart Failure . It reduces the severity of shortness of breath . respiratory noise   and edema .

Valsacor N160 . N80   and ND160   also contain an active ingredient such as hydrochlorothiazide . It helps to improve the therapeutic effect valsartan   and reduces the risk of side effects.

Hydrochlorothiazide   It is a diuretic, which belongs to the group thiazides . It has a hypotensive activity , Increases the excretion of sodium, potassium and chlorine, and water. After a single use of this tool can last for days. After 2 weeks from the start of the course there is development antihypertensive effect , The maximum of which can be obtained at 4-5 weeks of treatment.

The active substance is absorbed in the digestive tract. About 60% interact with hydrochlorothiazide plasma albumin The degree of communication valsartan above. It is rapidly absorbed after administration and excreted through the intestines and kidneys.

Mean bioavailability of valsartan - about 23%. The maximum reduction in blood pressure can be seen in 4 hours.

Valsartan in combination with hydrochlorothiazide bioavailability is reduced by approximately 30%. However, a significant impact on the kinetics of valsartan hydrochlorothiazide has not. The efficiency of this complex application is not reduced. The half - 9 hours.

Indications

Valsacor prescribed for:

• treatment of clinically stable patients with symptomatic cardiovascular failure   or asymptomatic left ventricular dysfunction   after suffering myocardial infarction ;
• Chronic Heart Failure   Class II-IV without use of ACE inhibitors ;
• hypertension .

Drugs are used for hydrochlorothiazide hypertension   as part of a combination therapy.

Contraindications

Valsacor, as well as funds with hydrochlorothiazide should not be taken for those who have a hypersensitivity to the drug. In addition, they are contraindicated in pregnancy . Lactation   and in childhood.

The dose of valsartan should be controlled if the patient previously suffered heart attack   or is   heart failure . The caution in the presence of the drug taking renal artery stenosis .

In addition, drugs with hydrochlorothiazide should not be used to treat liver diseases severe, violations of the kidney, the presence of the graft kidney function depending on the kidney the renin-angiotensin-aldosterone system . anurii , Need Hemodialysis . renal artery stenosis , Problems with electrolyte balance, symptoms hyperuricemia . Refractory hypokalaemia .

They are also prescribed with caution for those who have lupus erythematosus . aortic stenosis , Obstructive hypertrophic cardiomyopathy , Problems with the water and electrolyte balance, mitral valve stenosis . Those who drive cars or work with difficult and potentially dangerous machinery should also take these drugs with caution.

Side effects

Valsacor has the following undesirable effects:

• On the side CCC : heart failure Excessive reduction of blood pressure, orthostatic hypotension .
• On the side Musculoskeletal System : Pain in the back, arthralgia . myalgia .
• On the side Reproductive system : Decreased libido.
• On the side Nervous System : Fainting, headache . insomnia . dizziness . vertigo .
• On the side Respiratory System : Cough, sinusitis . pharyngitis , Respiratory tract infections, rhinitis .
• On the side Digestive System : diarrhea Nausea, pain in the abdomen.
• Other: hyperkalemia . asthenia , Weakness, swelling , Fatigue.

In rare cases, a violation of the kidneys, reducing the concentration hematocrit   and Hemoglobin . hyperbilirubinemia . thrombocytopenia , Increased serum urea nitrogen, neutropenia . hypercreatininemia , Increased liver transaminases , Rash, angioedema . itch .

Drugs with hydrochlorothiazide   in addition to the above may have the following side effects: chest pain, pneumonitis . vasculitis . agranulocytosis , A disorder of water and electrolyte balance, leukopenia . hives , Exacerbation of cutaneous manifestations of SLE, blunting appetite, toxic epidermal necrolysis , Vomiting, lower potency, arrhythmia . photosensitization . constipation , Bone marrow depression, paresthesia , Intrahepatic cholestasia . jaundice . depression , Blurred vision,   lupus-like syndrome . pancreatitis . hemolytic anemia . edema light .

Instructions for use Valsacor

The drug is taken orally to 2 times a day. For those who are appointed Valsacor pills, instruction provides the following doses:

• at hypertension   Recommended dosage - 80 mg per day. The combination with other antihypertensive medications;
• after acute myocardial infarction   means for taking over 12 hours. The initial dose - 20 mg 2 times during the day, after which it gradually increased to 40-160 mg 2 times during the day. Maximum dosage may be taken only after 3 months of receipt;
• in chronic Heart Failure   recommended initial dose - 40 mg 2 times during the day. You can gradually increase the dose to 80 mg or 160 mg 2 times during the day with good tolerability. Thus, the maximum daily dosage is 320 mg, divided into two steps.

If you experience symptoms renal failure   or hypotension   We need to reduce the dosage.

Drugs with hydrochlorothiazide is also designed for internal use 1 time during the day.

Instructions for use Valsacor H 80   and H 160   recommends starting with a minimum dose.

Those who do not reach target blood pressure as monotherapy valsartan   or hydrochlorothiazide   individually designate these products in doses respectively 80/12, 160/12 and 5 g and 5 mg. If necessary, they can be raised to a maximum daily - one tablet Valsacor H 160   or 2 tablets Valsacor H 80 . A recommended dose Valsacor ND160   in this case - 160/25 mg.

Overdose

So far, the cases of drug overdose data were not recorded.

It is known that valsartan   at higher doses can lead to a sharp decrease in blood pressure with adverse consequences (disturbance of consciousness, shock, etc.).

Hydrochlorothiazide   an overdose can lead to weakness, electrolyte imbalance, hypovolemia .

As treatment of minor severity of side effects applied chelators And symptomatic therapy. Correction expressed hypotension   carried out by the internal administration sodium chloride   (Solution 0, 9%).

Cooperation

Clinically significant interactions with other drugs Valsacor were observed.

It is known, however, that this combination of drugs with potassium-sparing diuretics   and nutritional supplements, which are composed of potassium, may cause hyperkalemia . So the dosage of the drug should be strictly controlled. Perhaps more significant manifestation of hypotensive effect.

In turn, the preparations increased with hydrochlorothiazide neurotoxicity salicylates , Side effects of cardiac glycosides Efficiency curariform relaxants And cardiotoxic and neurotoxic effects of agents with lithium.

These drugs also weaken the effect of oral hypoglycemic drugs and protivopodagricakih, Norepinephrine   and Epinephrine . They reduce the renal excretion of cytotoxic drugs and lead to enhancing their myelosuppressive action.

Furthermore, these drugs inhibit the excretion quinidine Increase the likelihood of allergy Allopurinol .

The hypotensive effect Valsacor N160, N80 and ND160 increase vasodilators . barbiturates . tricyclic antidepressants . beta-blockers . phenothiazines   and ethanol . A preparations that are characterized by a good degree of communication with the blood, increase the diuretic effect.

In combination with Methyldopa   you may receive hemolysis And in combination with Kolestiramin   decreases absorption.

Terms of sale

Drugs available only by prescription.

Storage conditions

Medications should be stored in the package. The temperature is not above 25 ° C.

Shelf life

Valsacor Shelf life - 3 years. In turn, the preparations stored with hydrochlorothiazide is necessary not longer than 2 years.

Analogs Valsacor

Analogs Valsacor   pharmacies following:

• Valsafors ;
• Valaar ;
• Valz ;
• Diovan ;
• Valsartan . Valsartan H . Valsartan Zentiva . Valsartan A ;
• Nortivan ;
• Tareg .

Valsacor N160 . ND160   and N80   analogs have the following:

• Valz H ;
• Duopress ;
• Co-Diovan .

Reviews Valsacor

Reviews Valsacor   It indicates that very often while taking this drug experience side effects. Often, when used there are strong headache . Some patients Adverse symptoms may be worse. However, side effects appear by no means all, so many people prefer this means of its more expensive counterparts.

Reviews Valsacor H 80 . H 160   and ND 160   also report the occurrence in some patients of side effects. However, the efficacy of these agents is doubt.

Price Valsacor

Cost Valsacor On average is about 250 rubles. It is quite feasible means relative to its peers.

Price Valsacor H 80   - About 230 rubles, and the price Valsacor H 160   300 rubles, Valsacor ND 160   - 375 rubles.