Description overdue on 09/15/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Retinoic ointment (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The main active ingredient, which is part of the tool - isotretinoin .

Furthermore, it may contain the following additional ingredients: BHT, emulsifying wax, glycerin, purified water, butylhydroxyanisole, vaseline oil, ethyl alcohol (95%).

Product form

The drug contained in aluminum tubes, enclosed in cardboard boxes.

Pharmacological action

The drug has dermatoprotektivnoe, keratolytic, protivoseboreynoe and anti-inflammatory effect.

Retinoic acid   It is a biologically active form vitamin A . It participates in the regulation of Cell Differentiation .

Pharmacodynamics and pharmacokinetics

It helps acne ointment. It is responsible for normalization terminal cell differentiation And hinders the formation of detritus   and slows hyperproliferation of epithelium . This leads to the fact that sebum is considerably reduced, normal skin, and an inflammatory reaction around the sebaceous glands are reduced.

For internal use of the active substance is absorbed from the gastrointestinal tract. The highest concentration in plasma - average 2, 5 hours. The low degree of bioavailability and a strong connection to plasma proteins. The active agent is cleaved in the liver to form metabolite 4-oxo-isotretinoin .

Indications

The tool can be used not only on blackheads . Also used by Retinoic ointment wrinkles . With aging of the skin, it helps in the restoration and renovation of cells. Retinoic ointment rejuvenation are in great demand at women after the age of 30 years.

Furthermore, for oral administration it is prescribed for severe nodulocystic acne For rectal use - in severe relapsing forms of acne   and rash with seborrheic process .

For outdoor use when the drug is used pustular acne papules . seborrhea . pink acne   and perioral dermatitis .

Contraindications

The drug can not be used pregnancy   and its planning, hypersensitivity to its components, breast-feeding . If ointment is appointed for oral administration, it is also not recommended for severe violations of the liver and / or kidney problems, excessive lipid levels in plasma, hypervitaminosis A . neoplasms .

For rectal use contra - diseases of the rectum.

Side effects

Application ointment may cause the following side effects:

• Dermatological : Dry mucous membranes, dermatitis . cheilitis , Hand-foot skin peeling, Sweating . paronychia , Sprawl granulation tissue . skin rash . itch . erythema . dystrophy   nails.
• On the side Nervous System : Appearance headache .
• On the side circulatory system : Change in the amount Platelet . anemia . neutropenia . increased erythrocyte sedimentation rate .
• On the side muscular system : Pain.
• On the side   senses : Decreased night vision, conjunctivitis , Photophobia, hearing loss, corneal opacities.
• On the side   digestive organs Nausea.
• On the side Metabolism : Increasing the concentration of triglycerides and glucose.
• Other: the appearance of epistaxis.

In rare cases also possible thinning hair, photosensitivity, vasculitis . depression , Suicide, seizures, intracranial hypertension . hepatitis . hyperostosis .

In addition, rectal and external application may appear rash, puffiness . itch , Redness of the skin.

Instructions for use Retinoic ointment (method and dosage)

Instructions on retinoic ointment provides oral initial dose - 500 micrograms per kilogram of body weight per day. The maximum dose per day - 1 mg per kg. Maintenance dose is 0, 1-1 mg per kg body weight during the day. Duration of treatment - 16 weeks. Repeat it only after 8 days. Means taken during meals. The daily dosage taken once or divided into several times.

When rectal 0, 5-1 mg per kilogram of ointment used once a day, taking a prone position. Instructions for use informs that the course is designed for 8-12 weeks. It can be repeated after 1-2 months.

For external use tool is applied to the affected area of ​​skin 2 times a day. Duration of treatment - 4-6 weeks.

Overdose

In case of overdose, this tool may cause red spots at the site of or near them. Perhaps the emergence of weak itching and increased sensitivity of the skin . In this case, application of the ointment should stop or reduce its concentration.

Overdose is possible towards the end of the course application.

Cooperation

The action of the active substance decreases ointment in combination with progesterone in microdozes.

In combination with antibiotics   groups   aminoglycosides   may develop intracranial hypertension And together with vitamins A   could increase the toxic effects.

Terms of sale

The tool allowed for OTC sale.

Storage conditions

Ointment should be stored out of the reach of children. Optimum temperature - 2-8 ° C, wherein the drug is in any case should not be frozen.

Shelf life

Keep the ointment should be no more than 2 years.

Analogs

Retinoic ointment has pharmacies following analogues:

• Dermoretin ;
• Isotretinoin ;
• 13-cis-Retinoic acid ;
• Retasol ;
• Roaccutane .

Their composition is close to Retinoic ointment.

Reviews of Retinoic ointment

Reviews of Retinoic ointment acne usually positive. Patients talk about the amazing efficiency of the tool. The main thing is not to use it during pregnancy and its planning. Some also point out that there were certain adverse reactions as rash, pain, dryness. Nevertheless, ointment helps.

Experts also recommend the use of her wrinkles. Many women after the age of 30 years post reviews of Retinoic ointment rejuvenation. They report that the funds helped to restore and renew the skin.

Price Retinoic ointment, where to buy

Price Retinoic ointment, an average of 250 rubles. Buy this drug can and Ukraine. Price Retinoic ointment in USD may be different. Basically, it offers an online store. Price Retinoic ointment in Ukraine on average 155 UAH. Many analogues of the funds have a higher cost. In addition, it is difficult to get them. For example, Retinoic acid   rarely in pharmacies.