Description overdue on 05/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on xeroform: Dosage and Administration
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Newborns
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Xeroform is a yellow powder with weak specific odor. Powder particles are small and do not have the correct crystal structure (ie, the powder is classified amorphous substances ).

As a matter of fact the main bismuth salt   (Bismutum) - a chemical element of Group V of the periodic system DI Mendeleev. Molecule tribromfenolyata   Bi formed from the serial communications oxide, bismuth hydroxide   from tribromophenol   radicals on the ends.

As used in the pharmaceutical industry tribromfenolyate bismuth   Serial Communications oxide, bismuth hydroxide We should consist of three parts.

Xeroform characterized by poor solubility parameters water . alcohols . ether   and chloroform   (it is even difficult to just wet with water), it is also slightly soluble in halogenated hydrocarbons   and oils. Content bismuth oxide   it is from 50 to 55%.

However, some sources of pharmaceuticals and several otherwise specified percentage of bismuth oxide.

So, in the 25th edition of the American Pharmacopoeia indicates that the content bismuth oxide   may range from 44 6 to 54 5% (or from 40 to 49% Bi), as in the 26th edition Ekstrafarmakopei Martindalya noted that the percentage of bismuth oxide   55 is approximately 74%.

It should be noted that none of these specifications does not correspond to a molar ratio of bismuth to tribromophenol at As the ideal structure in accordance with the formulas given in pharmacopoeias ratio is considered 3Bi / 2Tribromophenol.

In cases where the ratio is less, it will not match specifications substance, and if it increases, and approaches the performance 4Bi / 2Tribromophenol, finished product acquires a bright yellow color. If the ratio is higher, the final product is colored in white.

Product form

The drug has some form of release:

• epidermal powder packaged in containers with a capacity of 7 g;
• powder;
• kseroformnaya ointment for the treatment of skin lesions containing xeroform   at a dose of 10 mg, and petrolatum at a dose of 90 mg;
• kseroformnaya eye ointment (3%).

Furthermore, xeroform is an active ingredient of drugs such as Liniment balsamic   by AV Wisniewski and suppository   treatment Hemorrhoids   and damage to the anus " Anuzol ", Which are issued by the pharmaceutical company of" Nizhpharm ", Russia.

Pharmacological action

When using the expressed xeroform:

• decontamination;
• astringent;
• drying effect.

Pharmacodynamics and pharmacokinetics

Bismuth salt xeroform due to its pharmacological activity is used as a binder dries and disinfecting agent for various types of inflammatory lesions of the skin and mucous membranes.

The antiseptic effect, have been reported with the use of the drug is determined by its xeroform bactericidal   influence on the microorganisms, which is reflected in the ability of proteins to bind to their cellular membranes. The result of this process is the destruction of microbial cells.

Stypsis xeroform   is that when applied to the skin, wound and mucous surface provokes drug effect dehydration   and partial coagulation proteins Which protects the affected tissue from the inflammatory process feedback stimuli.

Like other drugs binding, it has local xeroform anti-inflammatory Weakly expressed anesthetic   and styptic   action.

The mechanism of action of the drug due to its ability to interact with proteins of various tissues and form sparingly soluble proteinaceous compound albuminates That during the deposition of the protective film is like a kind of protect sensitive nerves   irritation.

This process stimulates the tissue irritation and provoke the destruction of superficial cells, which in turn enhances local circulatory tissues Stimulates cell division , Increases the flow of tissue fluid.

In addition, xeroform helps:

• luminal narrowing of blood vessels;
• The decline in the permeability of blood vessels and reducing the amount of fluid excreted;
• inhibition of enzyme activity;
• the suppression of the activity of pathogenic microorganisms;
• drying wound surfaces;
• reducing skin sensitivity;
• weakening of inflammation;
• acceleration of wound healing and regeneration of damaged tissues.

In particular, these effects become noticeable in the affected tissue inflammation, which is expressed primarily decrease exudation And restrictions (and in some cases even complete cessation) stepping leukocytes As well as a decrease in the severity of festering.

In contact with blood products binders marked deposition proteins And blood clots. These properties based topical application xeroform and similar in its action substances in hemostatic   and anti-inflammatory drugs.

Antiseptic Which is achieved using xeroform, based on the fact that, by acting on tissues, a drug for life creates unfavorable pathogens   conditions.

Data pharmacokinetic   xeroform characteristics are absent. Because of the low toxicity of irritation and inflammation of the affected wound surfaces on the background of its application is not marked.

Indications

Xeroform drug is primarily intended for the treatment of inflammatory diseases   skin and mucous membranes. He also established himself as an effective means of:

• at skin dermatitis   origin of different nature (including the Diaper dermatitis   children);
• at ulcerative   and erosive   lesions of the skin and mucous membranes;
• at dartrous   defeat;
• at skin abscesses ;
• at boils ;
• in inflammatory lesions lymph nodes   ( lymphadenitis );
• while flowing in the acute or chronic inflammation lymph trunks   and capillaries, which is a consequence of inflammatory processes ( lymphangitis );
• at burns ;
• at frostbite ;
• at bedsores ;
• for minor skin injuries ( scratches   and abrasions , eg);
• at infected   skin lesions;
• at oprelostyah   (both in children and adults);
• postoperative (including septic and weeping) wounds;
• as Repellent   to control mosquitoes and other blood-sucking insects;
• and in lesions occurring in the acute form eye diseases ;
• for healing umbilical wound   in newborn infants.

Contraindications

Xeroform powder may be used to treat patients of all ages, from newborn babies to the elderly. The only contraindication to the drug is the presence of the patient's negative reaction to its use.

Side effects

Like most other drugs, xeroform can cause the development of unwanted side effects that are expressed in the form of allergic reactions of varying severity.

Most often, patients complain of:

• redness of the skin;
• the emergence of feelings burning ;
• rashes   skin;
• appearance edema ;
• itching   at the site of the drug.

In some cases, individual reactions may occur.

Any of these side effects is a prerequisite to an interruption of treatment xeroform.

Instructions on xeroform: Dosage and Administration

The drug is intended for outdoor use. In accordance with the instructions for use xeroform all his formulations is recommended to put on clean skin surface.

The powder or powder coated with a thin layer on the skin two or three times during the day. Due to its hygroscopic properties they effectively absorb sweat, exudate , Excess sebum, and also increase the surface evaporation and heat transfer performance.

A preparation in the form of an ointment or paste is applied to the cleaned surface of the wound, and then - if necessary - is covered by five or six layers of gauze dressing.

Eye ointment 3% Kseroformnuyu lay under the lower eyelid after thorough washing of the affected eye.

Overdose

Data on overdose are not available.

Cooperation

Interaction with other drugs is not established.

Terms of sale

The preparation is available in pharmacies without a prescription networks.

Storage conditions

Xeroform out of the reach of children, dry and protected from sunlight at a temperature not exceeding 30ºC.

Shelf life

The drug may be used for 5 years after the date of manufacture.

Cautions

If during treatment with the drug observed any violation of the patient's condition or drug does not have the expected effect and relieve the symptoms of the disease, it is recommended to stop taking it further and adjust the treatment regimen.

Avoid contact of powder or ointment in the eye. After using xeroform should wash your hands thoroughly.

The drug has no effect on ability to drive and work with other mechanisms.

Xeroform for newborns

Xeroform powder is indicated for newborn children as a means of accelerating the healing of the umbilical wound. Before applying powder, washed the wound hydrogen peroxide , The procedure is repeated twice a day - morning and evening.

It also effectively eliminates diaper rash and symptoms diaper dermatitis .

Application xeroform during pregnancy and lactation

Precise data on the efficacy and safety of xeroform in pregnant and lactating women is not so prescribed the drug to these categories of patients only permitted in cases where the opinion of the doctor's benefit to the mother outweighs the potential risk to the child.

Reviews

Numerous positive comments about xeroform confirm the efficacy of the drug. And he copes with problems that can not be eliminated by other means. The average score of the drug on sites with reviews of the product - 4, 5 points on a 5-point scale.

Among the disadvantages of money often celebrate it rather peculiar smell and the presence of only in specialized pharmacies.

Price xeroform

Price xeroform powder on the Russian pharmaceutical market varies from 75 to 115 Russian rubles. Buy in Moscow Kseroformnuyu powder or ointment can be in specialized pharmacies to prepare medications on the trunk (medical) words.