Description overdue on 12/15/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications for use of the drug
• Contraindications
• Side effects
• Glucophage tablets, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Slimming
• Reviews
• Price, where to buy

Composition

The tablets contain the active ingredient - metformin hydrochloride 500, 850, 1000 mg.

Additional components: povidone, and magnesium stearate.

Foil shell consists of hypromellose, while tablets of 1000 mg and more of Opadry Klia, macrogol 400 and 8000.

Product form

The medicine is available in tablets, covered with a white foil wrapper. Thus tablets of 500 mg and 850 have a circular shape, and 1000 mg - oval. It offers products for 20 pieces. in a cell by 3 cell in the stack.

Pharmacological action

Tablets have hypoglycemic effect.

Pharmacodynamics and pharmacokinetics

This drug can reduce hyperglycemia Without causing development hypoglycemia . When this is not stimulated secretion insulin Not shown hypoglycemic effect in healthy persons.

An increased sensitivity of peripheral receptors against insulin   and disposing Glucose   cells. Reduces the production of glucose by the liver by inhibiting gluconeogenesis and glycogenolysis. The drug inhibits the process of glucose absorption in the gastrointestinal tract.

To metformin   characterized by stimulation of glycogen synthesis, the impact on glikiencintetazu. Increased transport capacity of different types of membrane glucose transporters. Also, the drug has a positive effect on lipid metabolism: reducing the total content cholesterol , TG and LDL. During metformin in patients is maintained stable weight or moderately reduced.

As a result of ingestion celebrated a full absorption of the active substance from the gastrointestinal tract. Eating a meal can reduce and delay the process. The absolute bioavailability of metformin is 50-60%. The maximum concentration of the component in the composition of the plasma is detected after 2, 5 hours.

In the body,   metformin   rapidly distributed in tissues, virtually no binding to plasma proteins. The drug undergoes minor metabolism. Excretion is done by the kidneys.

Indications for use of the drug

The main indications for use of the drug are:

• treatment Diabetes   Type 2   in case of failure of the diet;
• Combination therapy with insulin in the presence of a pronounced degree of obesity, which is accompanied by secondary insulin resistance.

Contraindications

Glucophage is not recommended at the reception:

• diabetic ketoacidosis, precoma   and coma ;
• impaired renal function and liver;
• various diseases in the acute form;
• traumas and surgeries;
• chronic alcoholism, severe alcohol poisoning;
• lactation, pregnancy;
• lactic acidosis;
• period of 2 days before and after the radioisotope or radiological examinations involving administration of iodine-containing contrast agent;
• compliance hypocaloric diet;
• sensitivity or intolerance to the drug.

You should also refrain from using the drug in patients aged 60 years and engaged in heavy physical work with high risk of lactic acidosis.

Side effects

In the treatment with the drug may develop side effects in the form of disturbances in the digestive system such as nausea, vomiting, a metallic taste, loss of appetite, diarrhea, flatulence   and so on. Usually these symptoms occur at the beginning of therapy and then disappear on their own.

Also it is not excluded deviations in the metabolism of lactic acidosis Requiring discontinuation of treatment. Long-term use can cause Glyukofazh B12 vitamin deficiencies . In addition, there remains the likelihood of megaloblastic anemia and skin rashes.

Glucophage tablets, instructions for use (method and dosage)

According to the instruction on Glucophage, the dosage is adjusted individually and depends on the index of glucose in the blood.

This Instructions for use Glucophage 1000 mg, Glucophage 850 mg and 500 mg at the start of treatment is recommended to take a daily dose of 500-1000 mg. After 10-15 days of therapy allowed a gradual increase in dose, given the level of blood glucose. On average, the daily maintenance dose is 1, 5-2 grams, but not more than 3 years In order to reduce side effects associated with the work of the gastrointestinal tract, the daily dose divided into 2-3 receptions.

These pills are recommended to take at the same time or immediately after a meal as a whole. The duration of therapy is selected individually. Taking the drug for weight loss, you need a control specialist.

Overdose

While taking the drug Glucophage 850 mg overdose were observed. However, perhaps the development of lactic acidosis. For the early symptoms of disorders characterized by: nausea, vomiting, diarrhea, pain in the muscles and the abdomen, fever   and so on. Of complicated cases may be accompanied by rapid breathing, dizziness, impairment of consciousness   and development of coma .

If you have lactic acidosis should immediately stop taking Glucophage, in the hospital to find out the concentration of lactate, which will clarify the diagnosis. Subsequently, use hemodialysis allowing lactate and withdraw the drug from the body components. Then, the symptomatic therapy.

Cooperation

The simultaneous use of the drug and Danazol   It can lead to the development of hyperglycemia actions. If necessary, such a combination requires correction dosing and control of blood glucose levels.

Receiving high doses chlorpromazine   improves glycemia by decreasing insulin release. Any hormonal reduced glucose tolerance, increasing glycemia, can cause ketosis.

The combination of a "loop" diuretics retains the risk of lactic acidosis due to renal function.

Β2-adrenergic stimulants may increase the glucose in the blood. This requires monitoring of blood glucose, insulin possible appointment. The combination of Glucophage and derivatives sulfonylureas, insulin, acarbose, salicylates   enhance the hypoglycemic effect.

Terms of sale

The drug is released strictly on prescription.

Storage conditions

For storage of tablets designed dark, cool place, away from children.

Shelf life

Shelf life Glucophage 500 and 850 mg of 5 years, Glucophage 1000 mg can be stored for 3 years.

Analogs

The main counterparts are presented drugs: Bagomet, glucones, Gliformin, Gliminfor, Lanzherin, Metospanin, methadone, Metformin, Siafor   and others.

Glucophage and alcohol

It was found that alcohol can cause the development of lactic acidosis in acute alcohol intoxication. Aggravate the situation can the presence of liver failure, starvation or low calorie diet compliance. Therefore, in the period necessary to refrain from combinations with ethanol.

Glucophage slimming

It should be noted that this drug is very popular with people losing weight. However, reviews of physicians report that a way to combat obesity is very dangerous and can cause serious complications. However, this method is discussed in various forums, where users are interested in - like taking Glucophage for weight loss?

However, some people recommend taking Glucophage 500 mg, explaining that such a dose would be enough to "run metabolic processes." Others on the contrary advised Glucophage 850 mg, as a higher dosage "will only accelerate the process."

Interestingly, the responses for weight loss with this drug does not contain a description of specific results. But at the same time there are reports of worsening of the general state of health, the development of abdominal pain, nausea and even vomiting. Therefore, experts advise to start to watch your diet, which should be complete. It is necessary to exclude from the sweet, flour and fat and increase physical activity.

Reviews Glyukofazh

In most cases, the discussion of the drug associated with its use for weight loss. Here are some testimonials about slimming Glyukofazh report that their physician recommended this method as diet and exercise do not help to eliminate excess weight. Other users interested in how to take this medicine to lose weight quickly. In addition, you can find the stories of patients who took the pills to restore reproductive function.

However, the use of the drug for such purposes is not always effective. Moreover, as reviews of doctors and patients contain information about the development of serious pathology on the background of such experiments.

Reviews of Glucophage weight loss also do not describe concrete results. Although patients who take the medication at diabetes , Point efficiency and gradual weight loss.

Price Glyukofazh where to buy

Price Glucophage 1000 mg varies between 300-350 rubles.

Price Glucophage 850 mg is from 205 rubles.

Buy 500 mg tablets can be for 170-200 rubles.

The drug Glucophage, designed specifically for weight loss, is not issued.