Description overdue on 12/15/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Glucophage Long (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Tablets having a prolonged action, contain 500 or 750 mg of active substance - metformin hydrochloride.

Additional components: carmellose sodium, hypromellose 2910 and 2208 MCC, magnesium stearate.

Product form

Long Glyukofazh produced in the form of prolonged action tablets which are packaged in blisters 15 pcs, 2 or 4 blister packaging.

Pharmacological action

The drug has hypoglycemic effect.

Pharmacodynamics and pharmacokinetics

Metformin is biguanide from hypoglycemic effect Capable of lowering the concentration of   Glucose   consisting of blood plasma. He did not stimulate the production insulin Therefore it does not cause hypoglycemia . During treatment, peripheral receptors become more sensitive to insulin increases glucose utilization cells. Reduced synthesis of glucose by the liver due to inhibition of gluconeogenesis and glycogenolysis. Noting the delay glucose absorption in the gastrointestinal tract.

The active ingredient of the drug stimulates glycogen   by acting on glycogen synthase. Increased transport capacity of any membrane glucose transporters.

When treating metformin   Patients retain body weight or a modest reduction in its notice. The substance has a positive effect on lipid metabolism: reducing the level of total cholesterol, triglycerides   and LDL.

For tablets prolonged action characteristic of delayed absorption. Therefore, the therapeutic effect lasts for at least 7 hours. The absorption of the drug is not dependent on the food and does not cause accumulation. There negligible binding to plasma proteins. Metabolism occurs without the formation of metabolites. Excretion of components occurs in an unchanged form by the kidneys.

Indications

Glucophage is indicated for Long Diabetes mellitus type 2   in adult patients with obesity in cases of ineffectiveness of diet and exercise as:

• monotherapy;
• combination treatment with other hypoglycemic drugs or insulin.

Contraindications

The drug is not prescribed for:

• Sensitivity to metformin and other components;
• diabetic ketoacidosis . precoma, coma;
• violations or failure of the kidneys or liver;
• acute forms of various diseases;
• extensive injuries and operations;
• chronic alcoholism , Alcohol intoxication;
• pregnancy;
• lactic acidosis;
• use 48 hours before or after the radioisotope or radiological examinations involving the introduction of iodinated contrast agents;
  reduced-calorie diet;
• aged less than 18 years.

Caution in prescribing this drug should be exercised with regard to the elderly, people who do hard physical work, as this may cause the development of lactic acidosis In the treatment of lactating women.

Side effects

During therapy, the drug may develop lactic acidosis, megaloblastic anemia , Lowering the absorbability of vitamin B12.

It is also possible irregularities in the nervous system - a change of taste, gastrointestinal activity - nausea, vomiting, pain, diarrhea, loss of appetite. Usually these symptoms are concerned at the beginning of treatment and gradually disappear. To prevent their development is recommended in patients receiving metformin with or immediately after a meal.

In rare cases, possible variations in the activity of the liver and bile, the manifestation of skin allergic reactions .

Instructions for use Glucophage Long (method and dosage)

The tablets are for oral administration as a whole with a small volume of liquid. We recommend it daily during dinner.

According to the instructions for use, the choice of dosage tablets prolonged action carried out individually for each patient, taking into account the performance of blood glucose concentration.

Long Glucophage 750 mg and 500 mg may be administered both as mono- and combination therapy. It is important to adhere strictly to the dosage and regular monitoring of blood sugar levels.

Overdose

Receiving metformin   at a dose of less than 85 g does not cause hypoglycemia. But still a possibility of lactic acidosis.
If symptoms of lactic acidosis should immediately stop taking the medication in the hospital to determine the concentration of lactate to clarify the diagnosis. The efficiency of the procedure removal of lactate and metformin from the body by hemodialysis. Also held concomitant symptomatic therapy.

Cooperation

Development lactic acidosis   the combination can cause the drug to the iodine-containing contrast media. Therefore, for 48 hours before and after the radiological examination using iodine radiopaque recommended cancellation Glyukofazh Long.

Concomitant use of drugs with hyperglycemic indirect effect - hormonal agents, or tetrakozaktidom As well as β2-agonists, danazol, chlorpromazine   and diuretics It can affect the concentration of glucose in the blood. Therefore it is necessary to monitor its performance and when necessary to adjust the dosage.

Furthermore, the presence of renal failure   diuretics contribute to the development lactic acidosis . Combination with sulfonylureas . acarbose, insulin, salicylates   often causing hypoglycemia.

Combination with amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and vancomycin That are secreted in the renal tubules, enter into competition with metformin for tubular transport, which increases its concentration.

Terms of sale

Pharmacies Glyukofazh Long prescription.

Storage conditions

For storage of tablets designed dark, cool place, away from children.

Shelf life

3 years.

Analogs

The main counterparts of the drug: Bagomet, glucones, Gliformin, Gliminfor, Lanzherin, Metospanin, methadone, Metformin, Siafor   and others.

Alcohol

Alcohol consumption increases the likelihood of lactic acidosis   in acute alcohol intoxication . Enhancing observed fasting, subject to a low calorie diet, the presence of liver failure. Therefore, the use of alcohol during treatment must be abandoned.

Reviews Glyukofazh

Quite often patients leave reviews of Long Glucophage 750mg, as it is this dosage is indicated for the treatment of Type 2 diabetes   at its middle stage. The majority of patients report adequate efficacy. Often there are reports that when this medication is taken diabetics with high body weight, then later they noticed a moderate weight reduction to more acceptable performance.

Regarding Glyukofazh xr 500, the drug at this dose can be administered at an initial stage of treatment. In the future, it may be a gradual increase in dose to the selection of the most effective.

It should be noted that any hypoglycemic agents may appoint an expert only. In addition to competent medical treatment, the doctor will recommend a change in diet, exercise, which should be an integral part of the lives of people with diabetes. Only this approach will ensure a decent quality of life and not so acutely feel all the unwanted symptoms of this disorder.

Price Glyukofazh Long where to buy

Price Long Glucophage 500 mg per 30 pieces in a package of 270-300 rubles.