Description overdue on 05.12.2011

Non-steroidal, anti-inflammatory drug. The main active ingredient is the current acetylsalicylic acid . Aspekard has a strong antipyretic, analgesic, anti-inflammatory effect, which is achieved due to the braking cyclooxygenase   1, 2 and TSOG1 TSOG2 regulate production prostaglandins Responsible for the formation of edema, pain. Reducing the level of prostaglandins in the center of thermoregulation manifested sweating, vasodilatation of the skin, which leads to lower body temperature. The analgesic effect   achieved both peripheral and centrally acting drug. Aspekard reduces the adhesion, aggregation Platelet , Inhibits the production of thromboxane   in them, which leads to a reduction of thrombus formation. Antiplatelet effect   after a single dose of the drug lasts for a week (in men is more pronounced than in females). Before the drug reduced the risk of myocardial infarction with concomitant unstable angina Reduced mortality. Aspekard used for primary and secondary prevention of myocardial infarction. The daily dosage of 6 grams increases prothrombin time , Suppresses the production of prothrombin in the liver, increases fibrinolytic activity of plasma, stimulates the excretion of uric acid by violating its reabsorption in the renal tubule system. Available in tablet form ("fizzy" enteric).

Indications:

Aspekard used in   rheumatoid arthritis . pericarditis . rheumatism , Infectious-allergic myocarditis . Appointed for the relief of pain ( lumbago . neuralgia . migraine , Arthralgia, thoracic radicular syndrome, algomenorrhea ), Febrile syndrome. As an antiplatelet agent used in unstable angina, silent myocardial ischemia, stent, aortoarteriit , Balloon coronary angioplasty, prosthetic heart valves, atrial fibrillation, pulmonary infarction . mitral valve prolapse . acute thrombophlebitis , Recurrent pulmonary embolism, Dressler's syndrome . Kawasaki disease . Takayasu's disease . In allergy, immunology used in increasing doses in patients with "aspirin" triad and "aspirin" asthma.

Contraindications:

Aspekard not apply at hemorrhagic diathesis   (telangiectasia, von Willebrand disease , Hemophilia), ulcerative lesions of the gastrointestinal tract, dissecting aortic aneurysm, severe renal and hepatic systems, deficiency of vitamin K, the initial gipoprotrombinemii, nephrolithiasis , Hyperuricemia, thrombocytopenic purpura . Aspekard not use during pregnancy, breast-feeding, pediatric (14 years).

Side effect:

The drug can be accompanied Aspekard NSAID gastropathy, vertigo, tinnitus, leukopenia . thrombocytopenia . Reye's syndrome . bronchospasm , Urticaria, "aspirin" asthma, anemia, eosinophilic rhinitis, hyperplastic sinusitis. Long-term use of the drug in high doses leads to the development of pre-renal azotemia, interstitial nephritis , Nephrotic syndrome, papillary necrosis , Aseptic meningitis Acute renal failure. Marked increase in aminotransferases .

Mode of application:

Active rheumatism : Aspekard 5-8 grams per day for adults, 100 mg / kg for children, dosing frequency to 5 times per day. After two weeks of application dosage for children is reduced to 70 mg / kg per day. The course of treatment an average of 6 weeks, and then within 2 weeks dosage was gradually reduced until complete discontinuation. Pain, a feverish syndrome : Once 0, 25-1 gram, allowed 4-fold drug. The course of treatment no more than 2 weeks. Prevention of embolism, thrombosis : Three times a day for 0, 5 grams. Improve blood rheology 0, 15-0, 25 grams per day. Effervescent tablets Aspekard dissolved in 200 ml of water taken after eating.

Overdose:

There salitsilizma syndrome, seizures, stupor, coma , Severe dehydration, non-cardiogenic pulmonary edema , Shock, kidney failure system. Treatment: administration of activated charcoal, laxatives, vomiting provocation, alkalization of urine, induction of diuresis , The restoration of the BCC. At the level of more than 100mg% salicylates shown hemodialysis. If pulmonary edema is recommended mechanical ventilation with a mixture of oxygen mixture, with swelling of the brain shows osmotic diuresis   and hyperventilation .

Special instructions:

In appointing the drug for the purpose of pain relief treatment should not exceed 7 days, to reduce the heat - no more than 3 days. Before surgical treatment for the prevention of bleeding drug overturned 7 it before surgery. To reduce the irritant effect of the drug in the digestive tract at the same time it is recommended to use drugs that reduce gastric acidity, buffering agents to use, carefully grind the tablets before use. Aspekard has teratogenic effects on the fetus are not used during pregnancy, breastfeeding. Not compatible with ethanol.

Drug Interactions:

Aspekard reduces renal clearance, toxicity, efficacy Methotrexate NSAIDs, reserpine, thrombolytics, sulfonamides , Anticoagulants, heparin, oral hypoglycemic drugs. The drug reduces the effectiveness of antihypertensives, diuretics (furosemide, spironolactone), urikouricheskih (sulfinpyrazone, benzbromarone) drugs. Aspekard increases lithium salts, barbiturates . Digoxin   in blood. Myelotoxic funds increase gematotoksichnosti drug.