Description overdue on 26.10.2012

Non-steroidal, anti-inflammatory agent . The active component acts Diclofenac . The basic substance is a derivative of phenylacetic acid. The drug has analgesic, antipyretic and anti-inflammatory effects. The mechanism of action of the drug is based on the violation Feloran flow of metabolic processes arachidonic acid , Non-selective inhibition of cyclooxygenase-1, 2, reducing the concentration of prostaglandins in inflammatory foci. The maximum efficiency of the drug observed in the genesis of inflammatory pain syndromes. The drug has antiplatelet effect . Feloran available in tablet dosage form, in the form of gel, ointment, capsules, dragees, suppositories, solution.

Indications:

Feloran gel is prescribed for diseases of the musculoskeletal system inflammatory genesis: urarthritis , Rheumatoid arthritis, ankylosing spondylitis, juvenile chronic arthritis, psoriatic arthritis, rheumatic soft tissue injuries. The drug is effective for traumatic injuries of the joints, muscles, ligaments, tendons (bruises, sprains, excessive load). The drug is prescribed for pain syndrome: bursitis , Lumbago, rheumatic soft tissue abscess, myalgia,   sciatica , Lumbago, neuralgia. Diclofenac is shown in osteochondrosis, deforming osteoarthritis and other degenerative diseases of the musculoskeletal system. The drug is used in infectious, inflammatory lesions of the upper respiratory tract, accompanied pain   pronounced, with otitis, tonsillitis, pharyngitis, with a feverish syndrome, followed by infectious diseases, colds. Diclofenac appoint at adnexitis , Inflammatory processes in the pelvis, algodismenoree.

Contraindications:

Feloran not appoint at "Aspirin" triad : Intolerance of drugs pyrazoline series, acetylsalicylic acid, recurrent nasal polyposis, asthma. The drug is not applicable in case of intolerance preparations of NSAIDs, various bleeding disorders, tendency to bleeding, prolonged bleeding, Hemophilia , Violations of blood in the form of anemia, leukopenia, bleeding and digestive tract, erosive and ulcerative lesions of the gastrointestinal tract, children up to the age of six, when carrying a pregnancy, breastfeeding. Suppositories are not prescribed for traumatic injuries, inflammation of the rectum, hemorrhoids, rectal bleeding . In patients with hypertension, decompensated form of chronic heart failure, asthma, anemia, diverticulitis , Alcoholism, liver disease and kidney disease, the elderly, with concomitant diabetes , Edema syndrome induced acute hepatic porphyria, in the postoperative period, diseases of the digestive tract without exacerbation Feloran used with caution.

Side effect:

The digestive tract:   bloating, constipation, abdominal pain . abdominal distention , Nausea, dyspepsia, peptic ulcers, elevated liver enzymes, thrush , The defeat of the esophagus, gastrointestinal bleeding, perforation, dry mouth, colitis, pancreatitis, hepatitis, cirrhosis, gepatonekroz , Changes in appetite, hepatorenal syndrome. Nervous system:   cramps, aseptic meningitis , Anxiety, double vision, depression, weakness, drowsiness, and sleep disorders. Senses:   reduction and violations of the auditory, visual and taste perception, scotoma , noise in ears.   Skin:   toxic epidermal necrolysis, toxic dermatitis, alopecia, eczema , Alopecia, photosensitivity, pruritus, rash. Urinary Tract : Oliguria, proteinuria , Nephrotic syndrome, azotemia, acute renal failure, papillary necrosis , Interstitial nephritis.   Bodies of blood:   rarely aplastic and hemolytic anemia, thrombocytopenic purpura , Agranulocytosis, eosinophilia, leukopenia. Respiratory system: laryngeal edema, cough, bronchospasm . Cardiovascular system:   stagnant heart failure, increased blood pressure. Allergic reactions:   rapid anaphylactic shock, swelling of the tongue, lips and throat, anaphylactoid reactions .

Overdose:

Manifested by nausea, decreased consciousness,   hyperventilation , Headache, dizziness, blurred in the renal and hepatic systems, vomiting, epigastric pain, bleeding. Requires gastric lavage, timely appointment enterosorbents holding posindromnoy therapy aimed at eliminating the respiratory depression, irritation of the digestive tract, convulsions, disturbances in the kidneys and liver, improve blood pressure. Hemodialysis, forced diuresis   not proven effective and are not applied.

Mode of application:

Feloran taken orally .  Adults appoint 2-3 times a day on 25-50 mg .  After achieving the desired therapeutic effect, the amount of drug is gradually reduced with a subsequent transition to a dose of 50 mg / day .  The drug in tablet dosage form taken on an empty stomach is not liquid, as a whole, drinking plenty of water .  Long-acting forms of medication taken 1 time a day at a dose of 100 mg .  Feloran also injected intravenously .  Before intravenous infusion of the contents of one ampoule are diluted in a solution of dextrose, sodium chloride .  Intravenous administration is carried out during 30-180 minutes depending on the degree of severity of pain .  In the postoperative period for a cupping of of acute of pain syndrome is carried out the introduction of "of the shock» dose in an amount of 25-50 mg of diclofenac in during the 15-60 minutes .  Further, the infusion is performed at a rate of 5 mg per hour .  Feloran can be administered intramuscularly for the relief of exacerbations of chronic diseases .  The drug is administered singly, hereinafter move on to receive oral forms of .  Feloran rectally administered twice daily, 50 mg or 100 mg once a day 1 .  When migraine attacks suppositories administered at a dose of 100 mg once .  Repeated administration is performed optionally in the same dose .  Ointment Feloran applied thinly in an amount of 2-4 grams, lightly rubbed into the skin over an area of ​​inflammation 2-3 times per day .  The duration of treatment is 1-2 weeks .  The gel is applied 3-4 times a day in an amount of 2-4 grams .  After applying the of a medicament of the drug Feloran is necessary to wash your hands .

Special instructions:

For a more rapid achievement of the desired effect Feloran recommended to take half an hour before a meal. In other cases, the drug should be taken with liquid before, during or after meals, drinking plenty of fluids. Particular attention should be paid to patients with abnormal cardiac and renal systems because of the important role of prostaglandins   in process of maintaining renal blood flow. During treatment feloranom marked decrease in the rate of motor, mental reactions that can affect the performance of potentially hazardous work, driving vehicles. The gel and ointment may be applied only on intact skin. There is no need to impose an occlusive dressing. Long-term treatment with high doses causes the formation of systemic adverse reactions. The gel and ointment applied only externally, inadmissible contact with mucous membranes, eyes.

Drug Interactions:

Feloran can increase drug levels of lithium,   Methotrexate , Digoxin, cyclosporin plasma. The drug has a negative impact on the effectiveness of diuretic drugs. The likelihood of increased bleeding while taking thrombolytic agents   (urokinase, alteplase, streptokinase), antiplatelet and   anticoagulant agents . Diclofenac reduces the effectiveness of hypnotics and of hypotensive preparations, increases the risk of manifestations of adverse reactions of glucocorticosteroids and other preparations group NPVS. The drug increases   nephrotoxicity   cyclosporine, methotrexate toxicity. Acetylsalicylic acid   felorana reduces the concentration in the blood. Nephrotoxic effect of increasing severity while taking paracetamol. Plicamycin, valproic acid, tsefotetan, cefoperazone, cefamandole increase the likelihood of gipoprotrombinemii.   The drug reduces the effectiveness of hypoglycemic drugs. Corticotropin, colchicine, ethanol, and St. John's wort preparations increases the likelihood of gastrointestinal bleeding .