Description overdue on 07/29/2014
- Latin name: Osteogenon
- ATC code: M05BX
- Active substance: Ossein-hydroxyapatite compound
- Manufacturer: Pierre Fabre medicament Productions (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use osteogenon (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of the core of one tablet contains 830 milligrams osteogenon actively acting ossein-hydroxyapatite compounds Which, in turn, consists of collagens (216 mg) non-collagenous proteins and peptides (75 mg), calcium (178 mg), hydrophosphate (gidroksiapatit) calcium (approximately 444 mg), phosphorus (82 mg), inactive organic fractions (about 95 mg).
Additional auxiliary compounds included in the preparation can be isolated colloidal silica, potato starch, microcrystalline cellulose and magnesium stearate. The composition of the shell contains a medicament Valium , Titanium dioxide, and yellow iron oxide, talc and Macrogol.
Product form
Osteogenon produced in the form of tablets, coated light yellow lenticular shell and having an elongated shape. In one carton nominal volume of 800 milligrams contained, as a rule, 4 blisters of 10 tablets.
Pharmacological action
The drug inhibits bone resorption Stimulates osteogenesis And also helps in bone formation and simultaneously fills in the body calcium deficiency .
Pharmacodynamics and pharmacokinetics
Actively acting medicinal compounds in osteogenon performing the functions of regulator calcium-phosphorus metabolism . This drug is widely used in the treatment and prevention osteoporosis thanks to a twofold impact on the metabolism bone tissue. On the one hand, the drug stimulates osteoblasts , And with another - it renders inhibitory impact on osteoclasts .
Due to the content of the drug in the composition in a proportion of calcium to phosphorus of 1: 2, the drug promotes the absorption of calcium from the intestine, thereby promoting the development of PTH , Who, in turn, reduces bone resorption .
The drug helps slow down the process of the release of calcium from hydroxyapatite , That the blocks the manifestations hypercalcemia . Everything else, phosphorus contained in the chemical composition of the drug involved in the crystallization of hydroxyapatite, which helps to slow renal calcium excretion from the organism.
Due to presence of a drug such as an organic compound ossein bone remodeling occurs. The given process oppresses tissue resorption and stimulates bone formation . Osteocalcin Contained in the drug compound binds calcium and thus facilitates rapid crystallization of bone tissue, and collagen - It forms the bone matrix.
Indications
The drug is recommended to the use of at presence of the:
- osteoporosis of any complexity, including those resulting from arthritis . hyperthyroidism , Kidney and liver diseases, hyperparathyroidism, and immobilization Applying Heparin or corticosteroids;
- osteopenia and violations of balance the content of of calcium and phosphorus in the body, in including during pregnancy , And also in period breast-feeding ;
- bone fracture And to accelerate their healing.
Contraindications
The main contraindications to the use of the drug are:
- hemodialysis ;
- renal failure ;
- hypercalciuria ;
- idiosyncrasy of medicinal compounds that are part of the drug;
- age (is prohibited children at the age up to 18 years).
Side effects
Very rarely the drug can cause an allergic reaction to a part of the components of the drug. Furthermore, long-term use drug can trigger the development of hypercalciuria , and hypercalcemia .
Instructions for use osteogenon (method and dosage)
In accordance with the instructions on Osteogenon adults should take the drug into tablets of 2-4 to 2 times per day, for osteoporosis and 1-2 tablets a day - for the rest of the medical condition. The duration of the drug is determined in each case by the attending physician based on the patient's condition.
Overdose
No cases of overdose have been reported.
Cooperation
The drug can slow the absorption of antibiotics from the group tetracyclines bisphosphonates As well as medicaments containing iron. Therefore Osteogenon well taken together with drugs that have in their chemical composition of the above biologically active components, adhering to a 4-hour interval between the use of drugs.
Terms of sale
The drug is available only with a prescription.
Storage conditions
Osteogenon should be kept at a temperature no higher than 30 ° C out of reach of children.
Shelf life
Subject to the rules for keeping the drug retains its active medicinal properties within 4 years.
Cautions
People with impaired renal function should avoid the use of the drug for a long time.
Patients having a predisposition to urolithiasis It is vital to stick to a particular mode of administration and dosage of the drug.
Since Osteogenon contains in its chemical composition of a trace amount of sodium chloride, a drug approved for use in patients who suffer from hypertension .
The drug has no effect on the ability to drive vehicles.
Analogs osteogenon
Bivalos
At the moment, the free market can not meet the unique osteogenon. This means that drugs with a similar chemical composition which, as well as the drug will affect the course of bone mineralization and to act as a regulator of calcium and phosphorus metabolism in the body does not exist. However, the doctor can always get close by the action of the drug in the composition of which will contain other active active compounds.
Synonyms
Osteogenon
Babies
The drug is not recommended for use in the treatment of children under the age of 18 years.
During pregnancy and lactation
Because drug compounds contained in the composition of the drug, no harmful effects on the health and development of the unborn child, the drug can be used in pregnant and breastfeeding women.
Reviews osteogenon
Most of the reviews osteogenon for fractures are positive. We can say that this drug, doctors often prescribed for bone damage of varying severity. People who take the drug say that it does not cause side effects and helps in the prevention and treatment of various diseases associated with damage to the bone, including at osteoporosis .
Good respond about medicinal product pregnant women, as well as the nursing mothers, which have faced with calcium deficiency in the body. Reviews of osteogenon doctors can be called more than "cool." Many physicians really skeptical about this drug and its ability to influence regeneration bone, and therefore expressed quite divergent views at variance with assurances of the drug manufacturers.
However a quantity doctors, prescribing Osteogenon as a stimulator mineralization bone tissues is also large, the more that the effectiveness drug in each concrete case can differ. Therefore, at occurrence of doubts about forces of a medicament the impact of of the drug it is expedient to to spend study the state of of bone tissue with the help of X-rays , and Urine and blood for calcium in biological fluids.
Price osteogenon where to buy
Average price osteogenon (packaging, a nominal volume of 800 milligrams containing 40 tablets) will vary in the range of 550-600 rubles.