Description overdue on 11-11-2011

Main, an active substance - celecoxib . Effect of the drug is directed to the inhibition and TSOG2 prostaglandins , Thus achieving an analgesic, anti-inflammatory and antipiricheskoe action. Therapeutic doses of celecoxib not result in inhibition TSOG1 which regulates the production of prostaglandins responsible for during physiological processes. It does not affect the aggregation Platelet It does not violate the integrity and structure of the gastrointestinal mucosa. The maximum concentration of celecoxib is recorded within 3 h after a single dose. A fatty meal reduces the rate to peak concentration. Metabolism formulation components occurs in the hepatic system. The half - 11h. Ranseleks excreted in the bile.

Indications:

Ranseleks used to treat osteoarthritis . rheumatoid arthritis .

Contraindications:

Ranseleks not prescribed for allergic reactions NSAIDs . celecoxib . sulfonamides . Do not use in pediatrics, pregnancy, with severe renal pathology system.

Side effect:

The drug Ranseleks rarely leads to the development of side effects: dyspepsia, insomnia, flatulence , Epigastric pain, gastroesophageal reflux disease , Stomatitis, dysphagia . paresthesia , Asthenia, and constipation. Very rarely observed anemia , Hyperglycemia, increased hepatic enzymes, hematuria , Albuminuria, coronary vasospasm, blurred vision, hematuria , Tachycardia, erosion GASTROINTESTINAL TRACT, thrombocytopenia .

Mode of application:

For the treatment of osteoarthritis is prescribed 200 mg of the drug per day Ranseleks lump sum, or 100 mg twice.
In rheumatoid arthritis 100-200 mg administered twice a day.

Overdose:

At higher doses marked dyspepsia, gastrointestinal bleeding, sleepiness, anaphylactic shock. Is supportive, posimptomnaya therapy.

Special instructions:

In moderate renal and hepatic pathology systems the drug Ranseleks start with minimal doses. With caution is prescribed for peptic lesions of the gastrointestinal tract, bleeding history, cardiovascular failure, while taking ACE inhibitors, diuretics. Not intended for treatment of pregnant women, except for emergencies. Ranseleks reduces the speed of psychomotor reactions.

Drug Interactions:

Fluconazole   while admission to Ranseleksom leads to increased levels of celecoxib. ACE inhibitors lose their effectiveness, Furosemide   - Natriuretic effect. Formulations lithium accumulate in the body, reaching toxic doses. Antacids drugs reduce absorbability of of the drug Ranseleks. Tacrolimus , Preparations of NSAID cyclosporine   under the influence of celecoxib increase its nephrotoxic effect. Carbamazepine . rifampicin , Barbiturates reduce the level of celecoxib.