Description overdue on 28.10.2012

Non-narcotic, analgesic agent . The active component is paracetamol . The basic substance affects centers thermoregulation, pain, inhibit cyclooxygenase-1, 2 in the central nervous system. Cellular peroxidases have a neutralizing effect on the active ingredient of the drug in inflammatory foci, which completely blocks inflammatory effects . The drug has no adverse effect on the mucous wall of the digestive tract, for water and salt exchange It does not cause water retention and sodium ions. Tylenol manufactured in tablet dosage form as a syrup, capsule, solution, suppository, suspension, powder.

Indications:

Tylenol is prescribed for pain syndrome mild to moderate nature: neuralgia , Headache, arthralgia, algomenorrhea , Myalgia, toothache, migraine. The drug is indicated for feverish syndrome , Followed by infectious diseases.

Contraindications:

Tylenol is not indicated in case of intolerance of paracetamol in the neonatal period until the age of one month. When viral hepatitis, pregnancy, old age, breast-feeding, alcoholic liver disease, diabetes, lack of glucose-6-phosphate dehydrogenase, with benign hyperbilirubinemia , Liver failure, renal disease, Gilbert's syndrome paracetamol administered with caution.

Side effect:

Skin:   angioedema, rash, itching . Lyell's syndrome   (epidermal necrolysis toxic), Stevens-Johnson syndrome, exudative erythema multiforme . Central nervous system   (at higher doses of paracetamol): disorientation, agitation, dizziness. Digestive system:   epigastric pain, nausea, increased levels of liver enzymes, gepatonekroz. Endocrine system:   hypoglycemic coma, hypoglycemia . Forming Organs : carbohemia   (heart pain, shortness of breath, cyanosis), sulfgemoglobinemiya, anemia . Taking large doses can cause thrombocytopenia, leukopenia, aplastic anemia, agranulocytosis, pancytopenia. Urinary system:   papillary necrosis, renal toxicity in the form   interstitial nephritis , Renal colic.

Overdose:

The clinical picture of acute overdose unfolds through 6-14 hours after ingestion of the drug Tylenol. Symptoms of chronic overdose recorded after 2-4 weeks. There sweating, irregularities in the digestive tract (epigastric discomfort, abdominal pain, diarrhea, nausea, vomiting, eating disorders). At Chronic overdose   marked weakness, weakness, sweating, gepatonekroz , Hepatotoxic effect, which may be complicated by hepatic encephalopathy: a stupor, central nervous system depression, impaired judgment. Registers metabolic acidosis . convulsions , Coma, anticoagulation, cerebral edema, respiratory depression, development of DIC, arrhythmia, hypoglycemia. It recommended the introduction of precursors of glutathione synthesis, donators of SH-groups.

Mode of application:

Tylenol tablets are taken orally, drinking plenty of water, preferably after 2 hours after a meal. The single dose for adults is 500 mg, the maximum - 1 gram. The medicament administered up to 4 times per day. The duration of therapy 5-7 days. At Gilbert's syndrome , Hepatic diseases, renal systems is recommended to increase the interval between doses of the drug or reduce the dosage.

Special instructions:

Patients with alcoholic hepatosis   significantly increases the risk of liver tissue damage during the treatment with paracetamol. Prolonged febrile syndromes (more than 3 days) during treatment with the drug Tylenol is necessary to consult a specialist. The drug can distort the results of laboratory tests, affect the level Uric acid Glucose. Therapy Tylenol requires control over the work of the hepatic system, the state of the blood. Patients with diabetes, it is important to take into account the sucrose content of the syrup (in 5ml - 0 06HE).

Drug Interactions:

Tylenol is able to reduce the effectiveness of uricosuric medications . The drug enhances the effect of anticoagulant drugs   due to a decrease of synthesis of procoagulant factors in the hepatic system. Together with the admission of barbiturates, ethanol, phenytoin, phenylbutazone, rifampicin, tricyclic antidepressants , Phenylbutazone, inducers of microsomal oxidation, hepatotoxic agents increases the production of active hydroxylated metabolites that significantly increases the risk of severe intoxication, even when minor overdoses. The effectiveness of paracetamol is reduced by chronic administration of barbiturates. Upon receipt of ethanol increases the risk of acute forms of pancreatitis. The risk of damage is reduced hepatotoxicity while taking cimetidine, inhibitors of microsomal oxidation. Prolonged therapy Tylenol and other drugs from the group of NSAIDs increases the risk of renal papillary necrosis "Analgesic" nephropathy, as well as accelerates the onset of end-stage renal failure. Long and simultaneous treatment salicylates   paracetamol and leads to the development of cancer pathology of the bladder, renal system. Medicament diflunisal twice increases plasma concentrations of the active substance Tylenol, a 50% increased risk of hepatotoxicity . Gematotoksichnosti medication increases when applied myelotoxic agents.