Description overdue on 01/13/2013

An inhibitor of bone resorption. The active component acts alendronate . The drug is a non-hormonal specific inhibitor of bone osteoclastic resorption . The principle is based on the effects of the drug suppression activities osteoclasts . The basic substance is classified aminobisphosphonates and is an analog of pyrophosphate, which occurs under the influence of the binding of hydroxyapatite in bone. Alendronate helps to restore a healthy and bone with natural histological structure. The drug controls calcium and phosphorus metabolism Increases bone mineral density, increases process osteogenesis To help restore a positive balance between recovery and bone resorption. Alendronate is available in tablet dosage form.

Indications:

Alendronate is prescribed for osteoporosis in men at Paget's disease , In osteoporosis therapy with prolonged glucocorticosteroids . The drug is prescribed to postmenopausal women to prevent fractures of the spine, hip and other bones.

Contraindications:

Alendronate does not apply to hypocalcemia, intolerance basic substance alendronate at gestation pregnancy, chronic renal failure, breast feeding, if you can not, and the inability of their own in an upright position or sit for 30 minutes. Instructions for use of the drug Alendronate does not contain information about the effectiveness and safety of medicines for children.

Side effect:

Responses to the drug Alendronate indicate the following side effects From the senses: episcleritis , Scleritis, uveitis. On the part of the central nervous system:   migraine headaches expressed. From the musculoskeletal system:   osteonecrosis of the mandible, muscle cramps , Arthralgia, myalgia , Ossalgia. From the digestive system: dysphagia , Diarrhea, constipation, nausea, acid regurgitation, dyspepsia, epigastric pain, esophagitis, gastritis, ulceration of the intestinal wall, melena, erosion of the esophagus , Ulcer perforation on the background of a peptic ulcer, ulceration of oropharyngeal, esophageal stricture, bleeding from the upper gastrointestinal system. Possible allergic response in the form of a flu-like syndrome, rash, erythema , Pruritus, angioedema, hives , Toxic epidermal necrolysis, Stevens-Johnson syndrome, photosensitivity .

Mode of application:

Alendronate is prescribed once a day 1 2 hours before the meal, the tablet must be washed down with plain water without chewing. For the prevention of osteoporosis is prescribed 5 mg per day with postmenopausal osteoporosis dose increased to 10 mg. Paget's disease take medication for 6 months to 40 mg per day. Tablets coated with 70 mg administered 1 time per week.

Special instructions:

Tablets need to drink just plain water, t. To. Juices, tea, coffee, mineral water and other beverages a negative effect on the absorption of the drug. The medication immediately after morning rise reduces the irritant effect of the drug on the wall of the esophagus. After taking the pill should not take a horizontal position for half an hour because of the risk of esophagitis. Before treatment requires correction hypocalcemia . Therapy should start with diet, rich in calcium salts.

Drug Interactions:

At simultaneous reception antacids , Calcium supplements a decline Absorption . The recommended interval between alendronate and other medicines should be at least 1 hour due to increased severity of the risk of side effects.