Description overdue on 08.10.2011

The drug contains ibandronic acid Which is a highly nitrogen-containing bisphosphonate . This substance helps to prevent occurrence of bone destruction, which provokes the block function gonads . tumor . retinoids . However, it does not affect the process of replenishment pool osteoclasts. Ibandronic acid depressing effect on the process of bone resorption, but does not directly affect bone formation. The preparation Bonviva   slow bone turnover to the level of reproductive age in women during Menopause . Thus, there is a progressive increase in bone mass are significantly reduced performance cleavage bone collagen It increases bone mineral density. Ibandronic acid has a high efficiency and a wide therapeutic range, as a consequence Bonviva can flexibly dosed and used for periodic treatments.

Ibandronic acid rather quickly absorbed in the intestine. Thirty minutes later - the two hours and reaches the maximum concentration in blood plasma. However, the drug is poorly absorbed when taken together with food or drink. The exception is water. Maximum bioavailability observed in the fasting state. Approximately 40-50% of the quantity of the drug from the blood into the bone tissue penetrates and accumulates there. Some of the drug is bound to plasma proteins. The rest of the drug is excreted from the body through the kidneys.

Indications and methods of use of the drug:

Bonviva is used to prevention of fractures   in postmenopausal osteoporosis. Patients with osteoporosis are advised to take 1 tablet (150 mg) of the drug once a month. Thus each month pill must be taken at the same day.

The drug should be taken one hour before eating a meal or drinks. To wash down the pill can only clean water, swallowing it whole. After taking the drug can not lie for 60 minutes. If the designated day for the reception of the drug was omitted, the tablet should be consumed for at least for a week afterwards. If seven days have passed, the next dose should be taken at the designated day of the following month.

Contraindications and possible side effects:

The drug should not be taken in patients with severe hypersensitivity to ibandronic acid or any other of its components. As a side effect in some cases, may be a manifestation dyspepsia , Nausea, pain in the abdomen, diarrhea , Skin rash, headache, myalgia . After taking the first pill of the drug may briefly appear moderate flu-like symptoms. Special therapy they require.

If overdose may appear a number of side effects: upset stomach, heartburn , Gastritis, gastric ulcer. To bind Bonviva in the body, should eat milk or Antacids . No need to induce vomiting not to cause irritation of the esophagus. Patients must remain upright.

Specific recommendations:

Before therapy Bonviva need to carry out the correction of hypocalcemia and other disorders in the metabolism of bone and electrolyte balance. To do this, it is important to consume plenty of calcium and vitamin D. taking the drug should be immediately stopped if the patient showed signs of lesions of the esophagus. During pregnancy and lactation Bonviva is not recommended for use because the data on the harmful effects of the drug on today, no. The absorption of the drug may interfere with foods high in calcium and polyvalent cations. Therefore, they should be used no earlier than an hour after taking the drug. Similar recommendations apply to the data elements containing medicines.