Description overdue on 22.02.2012

Active ingredient - ibuprofen. The drug has analgesic, anti-inflammatory effects. Pronounced analgesic effect, it is shown at pain syndrome   inflammatory genesis. The mechanism of action on the basis of indiscriminate blocking cyclooxygenase 1 and 2, which leads to inhibition of development prostaglandins . Brufen has antiplatelet activity . It is produced in the form of gel, tablets, lotions, lozenges, drops, suspension, syrup.

Indications:

Brufen prescribed for degenerative diseases, diseases of the musculoskeletal system inflammatory genesis: osteochondrosis, psoriatic arthritis, ankylosing spondylitis , Juvenile arthritis, neuralgic amyotrophy, rheumatoid arthritis , Gouty arthritis. Brufen relieves pain: ossalgia, arthralgia, myalgia, migraine , Sciatica, toothache, headache, bursitis, tenosynovitis , Tendonitis, neuralgia, postoperative pain. The drug is prescribed for inflammation of the pelvic organs, algodismenoree , Adnexitis, a feverish syndrome with colds, infectious diseases.

Contraindications:

"Aspirin" asthma, ulcerative lesions of the digestive system,   Crohn's disease , Hemophilia, hypersensitivity, breastfeeding, bleeding diathesis, pregnancy. In cirrhosis of the liver, anemia, nephrotic syndrome, enteritis, gastritis, hypertension used with caution. In pediatric patients prescribed upon reaching 1 year.

Side effect:

The digestive tract:   bloating, diarrhea, NSAID-gastropathy, heartburn , Epigastric pain, loss of appetite, dry mouth, hepatitis, pancreatitis, constipation . Respiratory system: bronchospasm Passing shortness of breath. Senses : scotoma , Eyelid swelling, conjunctival edema, dryness of the eyes, double vision, toxic neuritis   optic nerve, tinnitus, hearing impairment. Nervous system:   insomnia, headache, agitation, hallucinations , Nervousness, depression, drowsiness, irritability. Cardiovascular system:   increased blood pressure, tachycardia, heart failure. Urinary system: cystitis . polyuria , Swelling, allergic nephritis, acute renal failure. May develop itching, Lyell's syndrome, fever, bronchospasm, anaphylactic reactions . hives . Allergic rhinitis , Thrombocytopenia, agranulocytosis, increased sweating.

Overdose:

The drop in blood pressure, epigastric pain, lethargy, vomiting, tinnitus, coma, metabolic acidosis , Respiratory arrest, Atrial fibrillation Aetiology. Recommended emergency gastric lavage, alkaline water, reception enterosorbents, forced diuresis , Posimptomnaya therapy (correction blood pressure).

Mode of application:

Brufen taken orally. Ankylosing spondylitis, osteoarthritis, psoriatic arthritis: three times a day at 400 mg ibuprofen. Treatment of rheumatoid arthritis: three times a day in a dose of 800 mg. Algomenorrhea: three times a day at 400 mg. Suspension: three times a day 5-10mg / kg. Feverish syndrome after immunization: 50 mg once, then after six hours of receiving repeated.

Special instructions:

Required monitoring of the hepatic, renal systems, peripheral blood. With the development of NSAID-gastropathy spend fibrogastroduodenoscopy , Evaluate the level of Hemoglobin . hematocrit , Examine stool for occult blood. It is recommended to simultaneously receive misoprostol or medicines PgE. Invalid alcohol intake. Brufen affects the speed of the motor, emotional, mental reactions.

Drug Interactions:

Tricyclic antidepressants, phenytoin, barbiturates, inducers of microsomal oxidation increase the production of active, hydroxylated metabolites that increase the risk of hepatotoxic reactions. When receiving inhibitors of microsomal oxidation reduce the risk hepatotoxic effects . Brufen reduce the hypotensive effect of vasodilators, reduces the effectiveness of uricosuric medications, strengthens action and effectiveness anticoagulants . Brufen increases digoxin, methotrexate in the blood. At simultaneous reception with caffeine increases the analgesic effect.