Description overdue on 05.06.2014
- Latin name: Chondroxide
- ATC code: M01AH25 (tablets), M02AH10 (gel, Ointment)
- Active substance: Chondroitin sulfate (Chondroitini sulfas)
- Manufacturer: Nizhpharm, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Chondroxide (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Tablets Chondroxide It contains 1 pc. chondroitin sulfate 250 mg; and calcium stearate, crospovidone , Microcrystallic cellulose, hydroxycarbonate magnesium - in the form subsidiary substances.
In 1 g gel for topical application contains chondroitin sulfate 50 mg; additional substance (dimethyl sulfoxide, propylene glycol, isopropanol, ethanol, sodium bisulfite, Nipasol, nipagin, carbomer, flavor "Orange") water.
In 1 g ointment for external use contains chondroitin sulfate 50 mg; as additional substances dimethylsulfoxide, lanolin, petrolatum, monoglycerides, water.
Product form
Pills white, 250 mg, 10 pcs. contour packaging, 30, 50, 60, 90, 100 pi. in a cardboard bundle.
Gel in aluminum tubes 20, 25, 30, 35, 40 g, ointment Chondroxide - 30 and '50
Other forms of of release - nyxes and capsules - y Chondroxide are absent.
Pharmacological action
The regulation of metabolism in the cartilage. It provides the regeneration of cartilage, hondrostimulyatsiyu, anti-inflammatory effect.
Accepts part in the construction cartilage and of bone tissue, improves metabolism in hyaline and the fibrous cartilage. It stops the degenerative changes in connective tissue and cartilage, provides inhibition of enzymes damaging the cartilage.
It activates the synthesis proteoglycans Regenerates the surface of the joint and the joint capsule, stimulates the production of synovial fluid. Inhibits bone resorption restores bone tissue and prevents loss of calcium.
The drug is slows the development of of osteochondrosis and of osteoarthrosis, reduces the soreness of affected joints. At reception of of the drug increases volume of movements in the affected joints.
Use of the drug makes it possible to reduce the dosage of NSAID.
Gel relieves pain and inflammation.
Pharmacodynamics and pharmacokinetics
Ingestion provides a maximum concentration in plasma for 4 hours, 4-5 hours - articular cavities. Bioavailability is 13%.
Maximum concentration in the cartilage of the joints is achieved within 48 hours. Excreted in the urine during the day.
Application of the gel due to the content of dimethyl provides efficient penetration chondroitin sulfate deep into the tissues. Maximum concentration when applied topically occurs within 30 minutes. The joint drug is retained for 5 hours.
Indications
For the treatment and prevention of degenerative lesions of the spine and joints ( osteochondrosis . osteoarthritis ).
Indications ointment for joints - local treatment of osteoarthritis and degenerative disc disease.
Contraindications
Tablet form :
- pregnancy and BREAST-FEEDING;
- children;
- idiosyncrasy of the drug and its components.
Carefully at propensity to bleedings.
To gel and ointment :
- damage to the skin at the site of application;
- Hypersensitivity to the composition;
- children's age.
Side effects
In rare cases, allergic reactions can occur when the pill - diarrhea, nausea.
Instructions for use Chondroxide (method and dosage)
Take two tablets with a small amount into the water twice daily. The recommended initial treatment to continue up to six months. After discontinuation of the therapeutic effect lasts for 4-5 months. depending on the development of the disease.
The local application (ointment, gel) is applied up to 3 times a day to the affected hearth. The gel is applied to pat until completely absorbed. The course of treatment may be from 2 to 8-12 weeks. Instructions for use ointments recommends applying the drug by rubbing into the skin, the treatment to 3 weeks.
Perhaps the appointment if required repeated courses of treatment on an individual basis.
Which is better: gel or ointment?
The gel is well relieves pain, does not require rubbing. Also, it does not stain clothes and leaves no residue on the skin, absorbs quickly, so do not need to spend a lot of time on the application. Ointment fat-based, well-suited for use in massage and self-massage.
Injections Chondroxide not available, but need to add treatment using injectable counterparts.
Overdose
Sometimes there diarrhea . nausea . vomiting . If long-term treatment at high doses may occur hemorrhagic rash. To eliminate symptoms used symptomatically.
Cooperation
The drug is able while taking exacerbate the effects of antiplatelet agents, anticoagulants, fibrinolytic agents.
Terms of sale
Pills - Prescription.
Gel . ointment - over the counter.
Storage conditions
Store in a place protected from children and not subject to temperatures exceeding 25 ° C. Ointment stored at temperature 2 ° - 20 ° C.
Shelf life
Pills and Gel Chondroxide - 2 years.
Ointment - 3 years
Cautions
You should avoid applying the product on broken skin and mucous membranes.
Analogs Chondroxide
There are analogues of cheap tablets - a Chondroitin - Agos and a large number of biologically active additives, the cost is 65 rubles, and expensive - Teraflex (contains in addition Chondroitin sulfate Glucosamine ) - The cost of 966 rubles, Struktum ( chondroitin sulfate ) - The value of 1100 rubles.
Price analogues ointment from 64 rubles. (cream Chondroitin ) To 150 rubles. ( Arthro-asset ).
Injections Hondrogarda and Mukosata are injectable counterparts - contain Chondroitin .
Synonyms
Chondroitin - Agos . Struktum . Hondrollar . Artrin
Babies
As the efficacy and safety of use in children has not been established, pediatric use only after consulting your doctor carefully.
During pregnancy and lactation
Tablets are contraindicated.
Forms for topical use with caution, after consultation with the doctor.
Reviews about the Chondroxide
Numerous reviews suggest that the pill is very effective for chronic administration for several months, and in the early stages of the disease. There are reviews of the gel as an effective means to relieve swelling and pain in the joints.
The ointment is widely used in physiotherapy - fonoforez using ointment is used to treat osteoarthritis as an effective and safe means, without causing side effects.
Price, where to buy pills
Price Chondroxide tablets 60 pcs. It ranges from 367 to 436 rubles. Cost gel in Russia it is between 239 rubles. for a tube of 30 grams, in Ukraine - 71 UAH.
Cost ointment in Russia is 30 g - 235 rubles.
How much is ointment in Ukraine? The price of a tube in 30 of 70 UAH.