Description overdue on 13.07.2012

Anti-inflammatory drugs . Active Ingredient - penicillamine . Kuprenil a complexing compound, which has immunosuppressive effects and detoxification. Since ions of iron, zinc, cobalt, gold, calcium, copper, mercury forms chelate complexes. The drug is able to inhibit some enzymes that participate in the sulfhydryl-disulfide exchange. The reaction with cysteine ​​leads to the formation of cysteine-penicillamine disulfide, which is characterized by a great solubility in comparison with cysteine ​​(at tsisteinurii marked reduction in the formation of kidney stones in cysteine ​​system). The drug acts on the various links immune system It suppresses the production of lysosomal enzymes, promotes neutrophil chemotaxis inhibition suppresses the activity of T-helper lymphocytes. Kuprenil breaks the connection between synthesized tropocollagen molecules that disturbs the process of synthesizing collagen.   Under the action of penicillamine reduced level rheumatoid factor It decreases the concentration of pathological macroglobulins. The effectiveness of the drug in the hepatolenticular degeneration   Provides enhanced excretion of copper in the urine, normalization of its content in the tissues. Kuprenil available in tablet dosage form, in the form of capsules.

Indications, contraindications:

Kuprenil prescribed for copper poisoning, gemosideroze , Wilson's disease, Scleroderma , Cystine nefrourolitiaze, poisoning inorganic compounds, with Fibroplastic form of glomerulonephritis, alcoholic cirrhosis of the liver (hepatomegaly accompanying) with cystinosis, cystinuria , Chronic hepatitis, rheumatoid arthritis.

Side effect:

Urinary system:   hematuria, nephrotic syndrome Jade. Nervous system:   myasthenia gravis, peripheral neuropathy , Polyneuritis caused by the lack of pyridoxine, a violation of taste perception. Musculoskeletal system:   polymyositis, arthralgia, dermatomyositis . Digestive system:   intrahepatic cholestasis, glossitis, thrush . pancreatitis , Nausea, vomiting, disturbance of appetite, diarrhea. Respiratory system: Goodpasture's syndrome , Diffuse fibrosing alveolitis, interstitial pneumonitis . Hemostasis of blood:   agranulocytosis, aplastic anemia, leukopenia, eosinophilia, hemolytic anemia . Perhaps the development of erythematous rash, fever, alopecia, breast enlargement with the formation galaktorei women, myalgia, volchanochnopdobny syndrome Allergic alveolitis, epidermal necrolysis toxic origin, skin rash.

Mode of application:

Kuprenil take on an empty stomach in. Wilson's disease:   initial dosage of 250 mg, a gradual increase in the amount of the drug to 0, 75-1, 5 grams per day. The dosage of the drug is considered to be effective in daily excretion of copper ions when urinating more than 2 mg after a week of treatment. Further dose adjustments made depending on the level of free copper ions in the blood. Cystinuria:   mean dose of 2 grams per day in 4 divided doses. Therapy requires abundant fluid intake, especially before bedtime. The first 4 weeks in chronic hepatitis, rheumatoid arthritis, scleroderma kuprenil take a dose of 125-250 mg. When registering good endurance increase the dose every 1-2 months 125 mg. The therapeutic effect is registered not earlier than 3 months of treatment. If efficacy is not observed after 3 weeks, then gradually increase the dose every 1-2 months on 125 mg. In the absence of positive dynamics in 6 months kuprenil overturned. When the desired effect of the drug taken in the same dosage for a long time.

Special instructions:

In the first six months of therapy is conducted regular monitoring of the state of the blood, the analysis of urine, blood every 2 weeks. After 6 months, the drug is prescribed monthly. Every six months, control of liver function and renal systems. When cystinuria, Wilson's disease for a long time prescribe pyridoxine (requires regular monitoring of the state of the urinary system, renal ultrasound). With the development of a lupus-like reactions, neurological symptoms, myasthenia , Lesions of the lung tissue, fever, hematuria, hematological symptoms kuprenil cancel and prescribe steroids. During registration Isolated proteinuria   continue therapy at not exceeding the figure 1g per day (in other situations, drug overturned).

Drug Interactions:

Chelate complexes are formed at the same time the use of iron supplements, gold. Phenylbutazone, levamisole, antimalarials increase the likelihood of increased severity of side effects. Kuprenil incompatible with antibiotics. Gematotoksichnosti medication increases when applied myelotoxic agents.