Description overdue on 26.01.2012

Vasodilators. Mainly active substance acts Cinnarizinum   - Calcium channel blocker in the smooth muscle tissue, which is widely represented in the vascular wall. The mechanism of drug action based on blockade of calcium influx into cells, which in itself contributes to the vasodilating effect. In addition, the active ingredient of the drug stugeron reduces the vasoconstrictor action of neurotransmitters such as the norepinephrine . vasopressin   and Serotonin . Cinnarizine affects membrane erythrocyte , Thereby improving the elastic properties of blood cells. This in turn helps to reduce blood viscosity   Advancement and microcirculation . The active substance reduces the degree of excitability of the centers vestibular It does not affect the frequency of contractions of the heart muscle and the blood pressure numbers. It binds to receptors histamine , So it has little antihistamine effect . When administered during the first three hours maximum plasma concentration is achieved, the drug in the body is fully metabolized and excreted by the kidneys (third) and intestine (two-thirds). Interval-life of 4 hours. Stugeron available in tablet form, in the form of capsules.

Indications:

Stugeron widely used in the treatment of diseases accompanied by all kinds of disturbances of the microcirculation. So Cinnarizine shown at the cerebral circulation of any etiology, appointed after suffering stugeron ischemic stroke , In cerebral atherosclerosis, encephalopathy dyscirculatory genesis. Due to the stabilizing effect on the centers of the vestibular system is shown at stugeron labyrinth disorders   (tinnitus and vertigo, accompanied by nausea and vomiting), as well as for prevention seasickness . With direct vasodilator action stugeron indicated for patients with peripheral circulatory disorders of various origins (when Raynaud's disease , Trophic ulcers, bedsores), and metabolic diseases associated with impaired tissue nutrition ( diabetes ), Arteriosclerosis obliterans and thromboangiitis obliterans .

Contraindications:

Contraindications for the purpose of drug stugeron a bit more, but are strict pregnancy, breastfeeding, hypersensitivity to the active substance. With such as Parkinson's disease pathology Cinnarizinum recommended to be used with caution, as there are cases of exacerbation of disease while taking this drug.

Side effect:

Nervous system:   drowsiness, headache and depression. Digestive system : cholestasia , Epigastric pain, dyspepsia, dry mouth. The skin may appear rash, sweating.

Mode of application:

Ypuskaetsya medicament in two forms for oral administration: in the form stugeron forte (a capsule dosage cinnarizine 75 mg) and a stugeron (tablet dosage cinnarizine 25 mg). In violation of the blood supply to the brain   Stugeron taken thrice daily dosage of 25-50 mg when labyrinth disorders   dosage normally does not exceed 25 mg (three times daily). For the prevention of "seasickness"   advised to take one tablet half an hour before the trip, then a tablet every 5-6 hours. In disorders of the peripheral circulation stugeron administered at a dosage of 75 mg, three meals throughout the day. In all cases, the drug is taken after a meal, the maximum dose - 225 mg, duration of therapy - lasting several months.

Special instructions:

No data of experimental studies that have pointed to the fact that the use of stugeron during pregnancy is fraught with complications to the fetus, however, recommended as far as possible refrain from appointing stugeron pregnant and nursing mothers. In Parkinson's disease stugeron prescribed only in the case, if the effect of potentially higher risks. Do not take alcohol during therapy. Caution is advised to take the people whose work requires attention and speed of reaction. If overdose may cause vomiting, hand tremors, drowsiness and weakness. No antidote, treatment is symptomatic - take sorbents, stomach wash, provide rest until symptoms disappear.

Drug Interactions:

If stugeron appointed simultaneously with the drugs depressing the central nervous system ( tricyclic antidepressants ), There may be enhancement of the effect of the latter. Also enhances the effect of cinnarizine nootropics . Stugeron intradermal distorts the results of diagnostic tests (in view of what has antihistaminic effect), however preferably before the appointment to refrain from taking the drug for four days.