Description overdue on 04/21/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

A tablet of 250 mg levodopa   and 25 mg carbidopa   monohydrate; Excipients - cellulose, magnesium stearate, starch, colorant AB @ C blue Lake 12% N2.

Product form

Tremonorm comes in tablet form levodopa   250 mg carbidopa 25 mg, 50 or 100 pieces.

Pharmacological action

Tremonorm has antiparkinsonian action.

Pharmacodynamics and pharmacokinetics

Parkinson's disease   occurs when a lack Dopamine in the brain. It is the metabolic precursor of dopamine Levodopa Which passes through the well blood-brain barrier (BBB)   and in the basal ganglia of the brain it is converted into dopamine, thereby facilitating the parkinsonian symptoms. When you receive inside the body   Levodopa   can quickly turn into a Dopamine   in peripheral tissues, and only a small amount of it goes to the brain.

Carbidopa   It is an inhibitor of the decarboxylation of aromatic acids, including levodopa BBB . Thus, a joint reception levodopa   and carbidopa   increases the flow to the brain levodopa .

Levodopa rapidly absorbed in the stomach. Meal slows absorption. A significant portion (75%) excreted in the urine, the rest - through the intestines.

Indications

Indications are:

• Parkinson's disease ;
• parkinsonian syndrome ( postentsefaliticheskogo Due to intoxication, and manganese oxide, carbon, cerebrovascular origin).

Contraindications

• closure form Glaucoma ;
• mental disorders;
• depression ;
• congestive heart failure;
• renal   and / or   hepatic failure ;
• leukopenia ;
• diseases of the endocrine system;
• pregnancy and lactation;
• melanoma ;
• children under 12 years;

You must use caution in diseases of the heart and blood vessels ( hypertension Expressed atherosclerosis . arrhythmia ), Diseases of the lungs and asthma , Propensity to erosive and ulcerative lesions of the gastrointestinal tract, with seizures.

Side effects

Initiation of therapy may be accompanied by nausea . vomiting . pain in the stomach , Swallowing disorders, worsening stomach ulcer . Sometimes it can be observed Arrhythmia . hypotension .

Prolonged use: spontaneous movement, hyperkinesis , Changes in the blood system, mental disorders, depression , Palpitations, sleep disorders, weight gain.

Instructions for use (method and dosage)

Tremonorm ingested. Titration is carried out individually for each patient. Starting dose - 1 tablet three times a day. Every 2 days the dose is increased to achieve the desired effect. The daily dose, which is the maximum: for levodopa   - 2r (8 tablets) for carbidopa   - 200 mg. Typically, the effect is achieved within a week.

Instructions on Tremonorm warns that when a Blepharospasm   or convulsive syndrome   the dose should be reduced.

Overdose

Excess doses causes hyperkinesis . nausea . vomiting insomnia . For treatment of overdose symptomatic therapy is shown receiving Activated Carbon , Gastric lavage.

Cooperation

Application to beta-agonists   increases the risk of arrhythmias .

Concomitant use with   tricyclic antidepressants   capable of reducing bioavailability levodopa ; from   diazepam, klozepinom, reserpine, clonidine, Mr. holinoblokatorami, papaverine, neuroleptics, pyridoxine   decreases antiparkinsonian   effect.

Application to lithium preparations   increases the likelihood of dyskinesias   and hallucinations And reception methyldopa exacerbates the development of side effects.

In the case of MAO inhibitors   their acceptance should be discontinued for 2 weeks because while the application there is the possibility of circulatory disorders, manifested in the development of dizziness , Excitation, tachycardia , Facial flushing, increased blood pressure .

Terms of sale

Prescription.

Storage conditions

In the reach of children and protected from light, temperature from 15 ° to 30 ° C.

Shelf life

Tablets in blister - 3 years; in a bottle - 4 years.

Cautions

neuroleptic malignant syndrome : Mental disorders, muscle stiffness . hyperthermia , Increase of CPK in the blood.

When translated into a combined reception levodopa   and   carbidopa Preceding reception levodopa stop for 12 hours before the appointment.

Patients should refrain from driving vehicles and work associated with high concentration of attention.

Analogs

On whom . tidomet . sindopa . Sinemet . Stalevo .

Babies

Do not use this to 12 years.

During pregnancy and lactation

Contraindications pregnancy   and breastfeeding .

Reviews

According to doctors - the choice of any drug should be carried out by a specialist with a careful selection of the optimal dose.

Price Tremonorma where to buy

packing 100 tab.