Description overdue on 04/21/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Tseraksona
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• Newborns
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

INN: Citicoline. Injection is composed of 500 or 1000 mg citicoline   (active ingredient).

Oral solution contains citicoline , and sorbitol . glycerol . glycerol . nipagin . Na citrate . nipazol .   saccharin Na . strawberry essence . Ponceau 4R dye .   K sorbate . citric acid (auxiliaries) .

Tserakson Tablets contain 522 mg of 5 citicoline sodium   (ekvivalent500 mg of citicoline). The drug in tablets also has in the composition magnesium stearate . talc . kremniyadioksid colloidal anhydrous . Hydrogenated castor oil . croscarmellose sodium (auxiliaries) .

Product form

Release form of the drug - solution for intramuscular and intravenous administration ; oral solution .

A solution for injection in ampoules contained 500 mg / 4 ml and 1,000 mg / 4 ml. The vials are made of colorless glass, protective tubes are made of plastic, white strips for fault. Ampoules are packed by 3 or 5 pcs. in a contour acheikova packaging, contained in a cardboard bundle.

The solution for the internal receipt contained in glass vials colorless glass with plastic lids. Bottle containing 30 ml of the drug. The bottle is packed in a pile of cardboard, the kit includes a syringe for dosing. The tablets are white, film coated, impression "C500". Blisters contains 5 tablets in a cardboard box embedded on 4 packs of tablets.

Pharmacological action

Citicoline (active drug substance) improves the function of ion exchange membranes pumps nervous system cells. This is due to the emergence of new phospholipids .

Tserakson / in and drops Tserakson provides stability neuronal membranes, thus reducing cerebral edema. As a result, the patient marked decrease cognitive impairment As well as the improvement of the functions of attention, memory. During the acute condition of the person at the stroke   drug treatment can reduce the volume of brain tissue lesions, helps to activate cholinergic transmission .

In people with traumatic brain injury treatment that means to reduce the duration of post-traumatic coma, the intensity of neurological symptoms. Under the action of citicoline reduced the duration of the recovery period after a stroke. Patients chronic hypoxia of the brain   when using the drug marked decrease in symptoms such as a lack of initiative, memory loss, difficulties in the process of self-service and perform common actions. Under the influence of of citicoline are reduced manifestations of amnesia It increases the overall level of consciousness.

Pharmacodynamics and pharmacokinetics

Given that citicoline is in the human body, therefore, endogenous   and exogenous citicoline   not delimited, to study the pharmacokinetics of the drug possible. 99% of the drug is absorbed from the gastrointestinal tract, its release occurs primarily through the kidneys.

Bioavailability is the same with any type of injection. When administered intravenously and intramuscularly citicoline metabolism occurs in the liver, forming choline   and cytidine . Citicoline is mainly distributed in the structures of the brain, choline fractions rapidly introduced into the structural phospholipids fraction cytidine introduced into the nucleic acids and nucleotides cytidine. Excreted by the kidneys and respiratory output only 15% received doses of citicoline person.

Indications Tseraksona

Indications for use of the drug as follows:

• acute ischemic stroke ;
• recovery after hemorrhagic   and ischemic stroke ;
• acute and recovery period after traumatic brain injury ;
• vascular disease of the brain Accompanied by behavioral problems and cognitive abilities.

Contraindications

The drug is contraindicated Tserakson take the following states:

• high sensitivity to the components that contain the drug;
• expressed vagotonia   (dominated by the tone of the parasympathetic part of the autonomic NS);
• hereditary nature of the disease, in which the observed intolerance fructose .

Side effects

The drug is rarely provokes the manifestation of side effects. In some cases, such manifestations are possible:

• allergic reactions (the appearance of of itching of the skin, rashes, as well as anaphylactic shock);
• dizziness   and headache ;
• tremor and feeling the heat, diarrhea , Nausea, vomiting, change in appetite;
• hallucinations Insomnia.

Sometimes the drug causes a sensation of numbness in the paralyzed limbs. It is also possible stimulation of the parasympathetic system, short changes in blood pressure and it can cause short-term changes in blood pressure.

If nyxes or syrup causes any of the above listed of phenomena, and if they to the same are compounded by, you must necessarily to consult to the doctor about expediency of the further of treatment.

Instructions for use (method and dosage)

Instructions on Tserakson for intravenous and intramuscular injection is the following. The drug is administered intravenously slowly, depending on dose, for 3-5 minutes. If the drug is taken by the drip rate to 40-60 drops per minute. Where possible, the drug is taken preferably intravenously, intramuscularly instead. In acute conditions, treatment should be started as early as possible, it is desirable to do so in the first day.

Application Instruction Tseraksona also depends on the disease being diagnosed in the patient. In the acute phase of traumatic brain injury and ischemic stroke should be administered 1000 mg every 12 hours, therapy lasts at least 6 weeks. Injections do for 3-5 days. Further, if the patient has not been disturbed swallowing function, you can take the tablets or syrup Tserakson.

The dosage of the drug during recovery doctor prescribes individually, depending on the severity and symptoms. Tserakson children administered strictly under doctor's prescription and in accordance with their specified dosage. Older patients no need to adjust an ordinary dosage.

When administered drug is diluted in half a glass of water. Drink it needed during food intake or between its reception. In the acute phase of stroke or brain injury is assigned 1000 mg (10 ml or one packet) every 12 hours, the treatment lasts at least 6 weeks.

Kids syrup is indicated for Tserakson central nervous system lesions of varying severity . Instruction in syrup for children is individual and depends on the severity of injury, age of the child, drug reactions, and others. For infants born very preterm, syrup administered twice a day for 0, 5 ml (50 mg) for children aged from two months - 1 ml (100 mg) twice daily. Further treatments individually prescribed by the physician, and the day the child should not take more than 5-20 ml of the drug. The solution which is contained in an ampoule, need apply singly. Use it should be immediately after addition, as an ampoule has been opened. Tserakson combined with isotonic solutions   and solutions dextrose .

Overdose

Given the fact that the drug is low toxic, overdoses were reported.

Cooperation

Citicoline may increase the effects on the body levodopa . Treatment Tseraksonom not carried out at the same time with the drugs, which is composed of meclofenoxate .

Terms of sale

Sold in pharmacies by prescription.

Storage conditions

Keep Tserakson should be in their original packaging. Protect from light. The drug may be stored at room temperature air (till 30 degrees).

Shelf life

Store can be 3 years.

Cautions

During treatment, these patients should be very careful about activities that require special care and quick response.

If the oral solution while kept in a cold place, it may be formed crystals due to the partial crystallization time preservative. If further drug store at room temperature, the crystals are dissolved for a few months. The quality of the drug remains high.

Analogs

Analogs Tseraksona - a nootropic drugs having similar effects on the body. This medication Neyrodar . Somazina . Somakson . Nootropil . Lecithin . Glycine . Gliatilin   and others. Some analogs are cheaper, but you can replace Tserakson only after approval of such actions with the doctor.

Synonyms

Somazina.

Babies

Children drug designate from birth, it is shown in the central nervous system.

Newborns

The drug is used to treat newborn premature babies. The treatment regimen prescribed by the doctor, depending on the individual characteristics of the infant state.

With alcohol

Combining the drug with alcohol is not recommended.

During pregnancy and lactation

To date there are insufficient data on the use of Tseraksona pregnant women. Animal studies have revealed no adverse effects on the body. However, the drug is prescribed only in pregnant women if the benefits of this treatment outweighs the potential risk to the unborn child.

Data on the allocation of the active substance is no milk, so the lactation period of treatment according to the drug should be stopped.

Reviews on Tserakson

Reviews of doctors about the drug, as well as those reviews, which patients are sent to a specialized forum, suggests that the drug is effective in the acute phase and during recovery after stroke and traumatic brain injury. Upon receipt of children parents have different ratings. In particular, they deal with as an effective positive impact that syrup, and the manifestation of certain side effects, such as hyperactivity   child. But to take the drug for adults and children, should only be under medical supervision.

Price Tseraksona where to buy

The vials Tseraksona can buy in Moscow for 1200-1250 rubles (5 vials 1000 mg). In Ukraine, packing with 5 ampoules of the drug 1000mg can be purchased for 400-500 UAH. In Dnepropetrovsk, the price of the drug in capsules is about 500-550 UAH.

Price Tserakson syrup (30 ml) in Russia is 700 rubles., The price of tablets (20 pcs.) - About 1500 rubles. Drops in Ukraine can be bought for as low as 320 USD.