Description overdue on 12/14/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications finlepsin
• Contraindications
• Side effects
• Tablets finlepsin, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

In tablets, the active ingredient is contained: carbamazepine   - 200 mg.

Additional components: MCC, gelatin, croscarmellose sodium and magnesium stearate.

Product form

Finlepsinum produced in the form of tablets, packaged in blisters 10 pcs, 3, 4 or 5 in a blister pack.

Pharmacological action

Tablets have finlepsin antiepileptic, antipsychotic   and analgesic action.

Pharmacodynamics and pharmacokinetics

For this antiepileptic means being a derivative dibenzazepine Also characterized antidepressant, antipsychotic, antidiuretic   and analgesic effect. Effect of the drug is related to the blockade voltage-gated sodium channels Contributing to the stabilization of overexcited neurons membranes, a decrease of synaptic impulses and inhibit production of discharges of neurons. Reduce the release of the neurotransmitter amino acids - Glutamate It is having a stimulating effect, which contributes to lower the seizure threshold of the nervous system, and hence the probability of occurrence of an epileptic seizure.

The efficacy shown in simple or complex epileptic seizures, which may be accompanied by secondary generalization   and so on. This was a decrease of symptoms anxiety, depression, irritability and   aggressiveness .

This characteristic of the drug is slow, but complete absorption Independent of food consumption. The concentration of the substance in the body is achieved within 12 hours after a single application Finlepsin retard   400 mg, maintaining therapeutic efficacy of 4-5 hr. The equilibrium concentration of active substance in the composition of the plasma is achieved after the therapeutic course of 1-2 weeks. However, this may depend on the characteristics of the metabolism of the patient: auto-induction of enzyme systems in the liver, geteroinduktsii other while taking the medicine, the patient's condition, the dosage and duration of treatment. It was found that carbamazepine passes into breast milk and through the placenta.

Drug metabolism occurs in the liver to form the major metabolites carbamazepine-10, 11-epoxide - active action and an inactive conjugate glucuronic acid . As a result of a metabolic process produced less active metabolite 9-hydroxy-10-methyl-karbamoilakridan capable of inducing its own metabolism. Withdrawal is carried out mainly in the composition of urine, and some - with the feces.

Indications finlepsin

The main indications for use finlepsin:

• various forms of epilepsy;
• neuralgia;
• pain when nerve disorders in patients with diabetes;
• different types of convulsive states - spasms, seizures, and so on;
• alcohol withdrawal syndrome;
• psychotic disorders.

Contraindications

Finlepsin not prescribed for:

• hypersensitivity   its components or tricyclic antidepressants;
• disorders of bone marrow hematopoiesis;
• acute intermittent porphyria ;
• AV blockade;
• while taking the drug lithium, or MAO inhibitors.

We recommend caution in patients with decompensated chronic heart failure, hyponatremia dilutions, liver and kidney disorders, elderly, active alcoholism, depression of bone marrow hematopoiesis, while taking certain drugs, prostatic hyperplasia, increased intraocular pressure, and so on.

Side effects finlepsin

Usually, the side effects of the treatment with this drug can develop due to excess dosage or significant fluctuations in the concentration of the active substance in the body. In most cases the occurrence of deviations in the nervous system: dizziness .   ataxia, drowsiness, general weakness, headache,   and so on. It is also possible manifestation allergic reactions , eg, urticaria, erythroderma , Skin rash and other symptoms.

Hematopoietic system and the occurrence of blood can respond: leukopenia, thrombocytopenia, eosinophilia, leukocytosis, lymphadenopathy . There remains the probability of abnormalities in the gastrointestinal tract: nausea, vomiting, dry mouth,   increasing the activity of gamma-glutamyl transferase, and the activity of liver enzymes, diarrhea   or constipation .

In addition, violations may occur related to the endocrine system and metabolism: edema, fluid retention, weight gain, vomiting, hyponatremia   And so on. Do not rule out the development of abnormalities of the cardiovascular and urogenital system, musculoskeletal system and sensory organs.

Tablets finlepsin, instructions for use (method and dosage)

This medicine is for oral use, regardless of the use of food.

When treating epilepsy   pills prescribed as monotherapy. If finlepsin attached to antiepileptic therapy, it is carried out gradually, strictly controlling the dosage. In cases where the reception is skipped pills, it should be taken immediately, as shown by the omission, but one should not pass a double dose to make up.

According to the instructions for use Finlepsin retard , To adult patients at the beginning of treatment prescribed daily dose of 200-400 mg. Then perhaps a gradual increase in dosage, can achieve optimum efficiency. Supportive daily dose is - 800-1200 mg, this amount is divided into 1-3 reception. The maximum permitted daily dose should not exceed 1, 6-2, the

For children, the dose depends on the age. Also, when a child is difficult to take the whole tablet, it can chew, crush and dissolve in a small amount of liquid.

Children 1-5 years prescribed 100-200 mg, the daily dosage is gradually increased to achieve the optimal effect.

Children 6-10 years old are encouraged to begin to heal from the daily dosage Finlepsin retard   200 mg, and the dosage is gradually increased.

The initial daily dose for children 11-15 years old is 100-300 mg. After that, it gradually increased from 100 mg until the optimal effect is manifest.

Average daily doses of support: for young patients 1-5 years - 200-400 mg, 6-10 years 400-600 mg, 11-15 years - 600-1000 mg, which is divided into several stages.

The duration of treatment is directly dependent on the evidence and the individual patient. In any case, all decisions related to treatment, are in the competence of the doctor. Usually the question of dose reduction or discontinuation of therapy is discussed when the patient no seizures for 2-3 years.

Discontinuation of treatment involves a gradual reduction in dose lasts 1-2 years, regularly monitor the EEG. At the same time children should take into account the increasing weight and age.

During treatment, other violations of indications, dosage and duration of admission establishes the doctor, given the complexity of the disease and individual patient characteristics.

Overdose

In overdose finlepsin can develop a variety of symptoms that indicate a violation of the nervous, cardiovascular and respiratory systems, sensory organs and general deviations.

This is evident: CNS depression, disorientation, sleepiness, agitation, hallucinations, coma, blurred vision, tachycardia , Failure of blood pressure, fainting, respiratory failure, pulmonary edema, nausea, vomiting, urinary retention and so on.

It was found that the treatment of overdose antidote is not so supportive treatment is carried out according to the symptoms manifested in severe cases - in the hospital.

Cooperation

The combination of this drug with inhibitors of CYP3A4   causes an increase in the concentration of carbamazepine   consisting of blood plasma and the development of adverse reactions. Combination with inducers of CYP3A4   often it speeds up metabolism   carbamazepine Reducing its concentration and therapeutic effect.

The simultaneous use verapamil, diltiazem, felodipine, dextropropoxyphene, viloksazina, fluoxetine, fluvoxamine, cimetidine, acetazolamide, Danazol, desipramine, nicotinamide,   and macrolides - erythromycin, josamycin, clarithromycin, troleandomycin,   Some azoles - itraconazole, ketoconazole   and fluconazole   can greatly increase the concentration of carbamazepine a . The same effect is typical for terfenadine, loratadine, isoniazid, propoxyphene , Grapefruit juice, inhibitors of viral proteases. The necessary adjustment of the dosage and monitor the concentration of the substance in the plasma.

By mutual lowering or increasing the concentration may result in a combination of felbamata   and carbamazepine.

Lower concentrations carbamazepine   It may also be: phenobarbital, primidone, metsuksimid, phenytoin, fensuksimid, theophylline, cisplatin, doxorubicin, rifampicin, clonazepam .   valproic acid, valpromid, oxcarbazepine   and a number of herbal products that contain St. John's wort.

Carbamazepine   It reduces the plasma concentration of drugs such as:   clobazam, clonazepam, ethosuximide, primidone, digoxin, valproic acid, alprazolam, cyclosporine, tetracycline, haloperidol, oral formulations containing estrogen   and progesterone   and so on.

Determined that tetracyclines   weaken the therapeutic effect carbamazepine . Use with paracetamol   increases the risk of toxic effects on the liver, reducing therapeutic efficacy. Combination with phenothiazines, pimozide, molindone, clozapine, haloperidol, thioxanthenes, maprotilinom and tricyclic antidepressants   dampening effect on the nervous system, weakening the anticonvulsant effect of the drug.

Therefore, when the patient is assigned finlepsin, you must immediately inform your doctor about any medications they are taking more.

Terms of sale

Finlepsin released strictly on prescription.

Storage conditions

To store the tablets require a dark, cool place, protected from the children.

Shelf life

3 years.

Analogs finlepsin

The main counterparts are presented finlepsin drugs: Aktinerval, Apo-Carbamazepine, Zagretol, Zeptol, Karbalepsin retard carbamazepine, Mazepin, Stazepin, Storilat, Tegretol and others.

Alcohol

Determined that carbamazepine Ethanol reduces portability. But also during drinking alcohol disease for which a given preparation can be expected side effects and development of various complications.

Reviews finlepsin

In most cases, people leave reviews about Finlepsin retard That they or their loved ones take several years. Some patients suffering epilepsy They note that the reception of the drug is undesirable impact on their intellectual activity leads to the development of apathy and violations of social communication. Nevertheless, despite these symptoms, patients confirm the high efficacy of the drug, allowing to forget about the attacks.

There are reviews Finlepsinum when used in the treatment of panic attacks associated with the fear of open or, alternatively, enclosed spaces. As a result of the treatment, in most cases the panic passes, but some remained concerned about the instability in gait.

Thus Finlepsinum is one of the most common anticonvulsant and antiepileptic drugs, which has been used successfully in clinical practice. According to experts, this means it is treated achieves incredible results. The main thing - to comply strictly with all the doctor's prescription in respect of dosage of the drug and lifestyle changes, to know exactly from what finlepsin pills and take them only when indicated.

Price finlepsin where to buy

The tablets finlepsin price in different regions of Russia differ slightly. At the same time buy finlepsin 200 mg of 50 pieces can be for 215-270 rubles. Cost Finlepsin retard (400 mg, etc.) varies in the range 260-330 rubles.