Description overdue on 13.07.2012

Antiparkinsonian . Active ingredient - biperiden . The main ingredient is a centrally acting anticholinergics. The mechanism of action is directed to inhibition of the activity of cholinergic neurons in the structural component of the extrapyramidal system - in the striatum. The medicament has ganglioblokiruyuschim effect , Antispasmodic and moderately severe peripheral m-anticholinergic effects. Akineton capable of eliminating catalepsy muscle rigidity Caused by the intake of neuroleptics and limb tremor in patients receiving cholinergic medicines, such as pilocarpine. Medications can cause agitation. Akineton available in tablet dosage form, in the form of solutions.

Indications, contraindications:

Akineton prescribed for extrapyramidal pathology Caused by classical neuroleptics (antipsychotic drugs), the syndrome of Parkinson's disease, Parkinson's disease.

Akineton does not apply in case of intolerance biperiden, with megacolon, prostatic hyperplasia, with angle-closure glaucoma , Hypersensitive to the active substance biperiden at bowel obstruction . When arrhythmia, epilepsy, breast feeding, elderly patients, pregnancy Akineton used with caution.

Side effects, overdose:

Paresis of accommodation . constipation , Dyspepsia, hallucinations, confusion, fatigue, weakness, drop in blood pressure, dry mouth, urinary retention, allergic reaction, catalepsy , Anxiety, drowsiness, dizziness.

In case of overdose there is a marked anticholinergic effects. Requires the introduction of cholinesterase inhibitors , Posindromnoe treatment.

Mode of application:

Akineton applied intramuscularly, intravenously, tablet form - inside. Dosing biperiden carried out individually. Extrapyramidal disease when receiving neuroleptics (antipsychotic drugs): a single dose of 2 mg intravenously or intramuscularly, repeated dosing is carried out every half-hour, but not more than four times a day; tablet form of the drug Akineton take 1-3 times a day to 2 mg. In Parkinson's disease: 2-4 times a day to 2 mg orally, gradually increase the dose of 6-16 mg.

Special instructions:

Akineton can be administered to children. The decision on the appointment of biperiden during breastfeeding, when carrying a pregnancy take, given the likely risk to the infant, fetus. With a sharp lifting of the drug observed abstinence syndrome It recommended to reduce the dosage gradually. The drug causes dizziness, affects the management of vehicles, speed of psychomotor reactions.

Drug Interactions:

Akineton enhances the effects of antihistamines, antiepileptics, antiparkinsonian medications, Mr. holinoblokatorov It weakens the action metoclopramide . In appointing quinidine increases the risk of developing dyskinesia. The use of levodopa increases the severity of m-cholinergic effect. Akineton fully compatible with ethanol.