Description overdue on 07/11/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Azaleptinum
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

One tablet contains 25 mg or 100 clozapine . Furthermore the medicament contains excipients such as lactose monohydrate . calcium stearate   and potato starch .

Product form

The drug is available in tablets.

Pharmacological action

Azaleptin (INN - Clozapine ) Belongs to the neuroleptics   and it has sedative properties. He works as a sedative and hypnotic properties and has enhances the effect of painkillers.

Pharmacodynamics and pharmacokinetics

At the beginning of the drug prevails sedation. In patients, a decrease motor excitation . impulsiveness . aggression . normal sleep .

Azaleptin well absorbed in the gastrointestinal tract. The maximum blood concentration reached an average of 2 and 5 hours after eating. It spreads rapidly in the body and accumulates in the light . liver . kidney . Communication with the plasma proteins - 95%. Excreted through the kidneys and bowels. It does not reduce mental activity and does not affect the level of prolactin in the blood.

Indications

Acute and chronic forms   Schizophrenia . affective insanity , Various psychotic conditions   when excited, mania . psychomotor agitation . Furthermore, in some cases Azaleptin administered with resistance to treatment with other neuroleptics.

Contraindications

The drug should not be used at granulocytopenia . coma . disorders of bone marrow hematopoiesis . agranulocytosis a history myasthenia . pregnancy . Lactation , Hypersensitivity to the components Azaleptinum, as well as children up to 5 years.

Side effects

Occurrence granulocytopenia . eosinophilia . agranulocytosis   and leukocytosis   unknown etiology (usually during the first weeks of treatment).

On the side autonomic system   there is a probability of occurrence dry mouth . Hyperthermia . accommodation disturbances . thermoregulation   and sweating And excess   salivation .

On the side   digestive tract and liver   may nausea . constipation   or vomiting .

On the side Nervous System   possible side effects such as drowsiness . dizziness , Increased   fatiguability . headache .

On the side Cardiovascular   you may receive tachycardia . orthostatic hypotension . In the first week of application and fainting occur.

On the side urinary system : urinary incontinence   or urinary retention .

In rare cases, there collapse Which is accompanied by a stop or shortness of breath, arterial hypertension . arrhythmia , ECG changes, hypertension I , Increased activity liver enzymes . cholestasia , Extrapyramidal symptoms. There are some reports about the development skin reactions .   rigidity, akathisia . tremor , Malignant   neuroleptic syndrome Suddenly death   for prolonged use. Moreover, the weight may increase.

By increasing the dose the risk that there will be side effects increases.

Instructions for use Azaleptinum

Tablets are ingested after meals 2-3 times a day, they must be washed down with a small amount of liquid. If the patient is prescribed Azaleptin, instructions for use provides multiple gestations. Single dose for adults ranges from 50 mg to 200 mg, the initial daily dose - 200 mg average daily dose - 300 mg, the highest daily dose - 600 mg. The exact dose picked individually. It is better to start with a small amount of the drug gradually increasing its consumption of 25-50 mg per day until a therapeutic effect is achieved. Instructions for use Azaleptinum announces that it will be gradual.

Please come hypnotic   and sedative , the decreased   psychomotor agitation . worry . aggressiveness   (average 5 days), then we should expect antipsychotic effects   (1-2 weeks) and only then would the drug effect on symptoms negativity   (approximately 1-1, 5 months). After that you should move on to support the course.

Overdose Azaleptinum

Overdose Azaleptinum dangerous because it may be poisoning. Its symptoms include stupor . drowsiness , Increased   anxiety . tachycardia . collapse , Shortness of breath, coma . seizures . hypotension . In overdose intended application sorbents Maintaining the respiratory and cardiac systems and symptomatic treatment.

Cooperation

At the same time Azaleptinum contraindicated to use drugs that can have a significant depressing effect on the work of the bone marrow.

In addition, the drug may potentiate MAO inhibitors   and tools that suppress the central nervous system.

At the same time it must be used with caution in preparations that are anticholinergic   and hypotensive effect As well as respiratory depression.

If Azaleptin use in conjunction with pharmaceuticals, which have an affinity with the cytochrome P450 1A2   or cytochrome P450 2D6 , May increase the concentration of one or both drugs in plasma. However, clinically significant interactions are still was not fixed when combined with clozapine tricyclic antidepressants   and antiarrhythmics C-Class . Nevertheless, increasing their concentration in the blood plasma is theoretically possible, so it is advisable to use these drugs at a lower dose. The same applies to formulations that have a high degree of coupling to the protein.

Agents that stimulate the enzyme system P450 May, in turn, reduce the concentration of clozapine in plasma.

Application together with Azaleptinum Cimetidine   or Erythromycin   at the same time could lead to an increased concentration of clozapine in plasma, because of which there are side effects.

In addition, it reduces the effect of many Azaleptin dofaminostimulyatorov . And its simultaneous with drugs that affect the nervous system, can increase the risk of malignancy neuroleptic syndrome .

At the use of gelled antacids   and cholestyramine   Azaleptinum absorption from the gut deteriorates. In addition, be sure to use caution when taking this drug in conjunction with antipsychotic . psychotropic . antiepileptic . hypoglycemic . sedatives   and antimicrobials And derivatives sulfonylureas .

Azaleptin can reduce the hypertensive effect noradrenaline   and eliminate pressor effect adrenaline .

Terms of sale

Released the tool strictly on prescription.

Storage conditions

Store this medication should be in a dry, dark place, away from children. The optimum temperature - not higher than 30 ° C.

Shelf life

Azaleptin if all the conditions are stored for 3 years.

Analogs

The main counterparts of the funds - Azaleptol   and Azapin . All are available in tablets with the active substance 100 and 25 mg. In many cities where analogues of Azaleptinum accessible, so often their doctors prescribe it.

Azaleptin and alcohol

Apply Azaleptin and alcohol together experts do not recommend. The drug is largely enhances the action of alcohol on the central nervous system.

Reviews Azaleptinum

Positive reviews Azaleptinum indicate that the tool is very effective in acute schizophrenia. In addition, the doctors say that he is very good at manic states . unproductive mania with delirium As well as classical and atypical mania . The forums reviews Azaleptin in regard to its positive action in affective insanity   and various psychotic disorders Definitely positive.

However, this tool should be taken with caution as there is a risk of side effects in case of overdose or the wrong combination with other drugs. So the question of whether to let Azaleptin prescription or not, in fact, is not necessary. Without surveillance specialist to use this means is not recommended.

Price Azaleptinum where to buy

Azaleptinum average price ranges from 120 to 670 rubles. Much depends on the region, as well as the content of the main active ingredient in the tablets. Average price Azaleptinum in which 25 mg of clozapine - 200 rbl., And 100 mg of clozapine - 650 rubles.

Despite the fact that the drug is considered effective enough to buy Azaleptin in Moscow is not so simple. It is rare to find in pharmacies. Buy without a prescription is a means and not succeed.