Description overdue on 22.07.2012

Muscle relaxants centrally acting . The active substance is a GABA-stimulant derived from gamma-aminobutyric acid. The mechanism of action is aimed at the suppression of the intermediate neurons, decrease the excitability of the sensitive parts of the terminal, the afferent fibers, oppression monosynaptic, polysynaptic transmission   nerve impulses, which leads to a reduction in prestressing muscle tissue. The drug baclofen has no effect on neuromuscular transmission . The drug is able to facilitate the active and passive kinesitherapy , To increase the range of motion in joints, weaken clonic seizures   and painful spasms in neurological diseases that manifest skeletal muscle spasticity. Baclofen is available in tablet dosage form.

Indications:

Baclofen prescribed for spasticity in stroke, multiple sclerosis , Spinal diseases (traumatic, neoplastic, degenerative, infectious rpoiskhozhdeniya), meningitis, traumatic brain injuries, alcoholism (affektornaya pathology), with cerebral palsy.

Contraindications:

Baclofen is not applicable in Parkinson's disease, psychosis, convulsions in the history of epilepsy, intolerance of the main substance, cerebrovascular , Chronic renal failure. When carrying a pregnancy, ulcerative lesions of the gastrointestinal tract, with cerebrovascular insufficiency, breastfeeding Children under 12 years of age and elderly persons prescribed Baclofen with caution.

Side effects, overdose:

Baclofen is asthenia , Dizziness, drowsiness, vomiting, nausea, paresthesia, drop blood pressure . constipation , Diarrhea, urinary retention, abnormal gait, confusion, tremor , Ataxia, myasthenia , Myalgia, depression, eyoriyu, apathy , Enuresis, dysuria, hallucinations, paresis of accommodation , Nystagmus, decreased seizure threshold, seizures. Long-term therapy causes disturbances in the hepatic system. Overdose is manifested by coma, confusion, hypotonia , Depression of the respiratory center. Required assignment diuretics , Excessive drinking, the oppression of breath - holding ventilation. Antidote is not developed.

Mode of application:

Baclofen take before meals inside. Initial dosage is 5 mg three times a day, then every three day dose of baclofen is increased by 5 mg to achieve a therapeutic effect. The maximum dose - 100 mg per day in a stationary observation. Final dosage is selected on the basis of such a decrease in muscle tone that will not worsen motor function and not lead to excessive myasthenia. Individuals with hypersensitivity appoint 5-10 mg per day with a possible subsequent increase in dose. In hemodialysis, in CRF daily dosage is 5 mg. Baclofen cancel within 1-2 weeks gradually.

Special instructions:

Side effects of the drug baclofen may be transient. It is important to distinguish between the side effects from symptoms of the underlying disease. Patients with epilepsy drug administered without concomitant antiepileptic medications cancellation. At diabetes , Hepatic pathology system is carried out regular monitoring of blood glucose, liver enzymes. Baclofen affects the concentration and control of vehicles.

Drug Interactions:

Baclofen is capable of potentiating the effects of drugs that affect the central nervous system, ethanol and protivopodagricakih antihypertensives . Agitation, confusion, hallucinations   observed while taking levodopa, carbidopa with levodopa. Tricyclic antidepressants   can enhance the severity of reducing muscle tone.